Experiment set10IT084 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Nalidixic acid sodium salt 0.00000195313 mM

200 most important genes:

  gene name fitness t score description  
b4237 nrdG -3.7 -10.1 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b4238 nrdD -3.6 -18.2 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b3035 tolC -3.4 -8.2 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b0222 lpcA -3.4 -2.3 phosphoheptose isomerase (NCBI) compare
b3199 yrbK -3.1 -3.6 hypothetical protein (NCBI) compare
b0053 surA -2.8 -3.8 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b3977 tyrU -2.7 -1.4 tRNA-Tyr (NCBI) compare
b2512 yfgL -2.7 -6.3 protein assembly complex, lipoprotein component (NCBI) compare
b1677 lpp -2.4 -2.8 murein lipoprotein (NCBI) compare
b2617 smpA -2.4 -3.9 small membrane protein A (VIMSS) compare
b1236 galU -2.4 -3.3 glucose-1-phosphate uridylyltransferase (NCBI) compare
b4201 priB -2.4 -2.8 primosomal replication protein N (NCBI) compare
b3620 rfaF -2.3 -5.9 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b0683 fur -2.3 -1.6 ferric uptake regulator (NCBI) compare
b1830 prc -2.3 -5.0 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b3621 rfaC -2.3 -4.8 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b0902 pflA -2.2 -6.5 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b3619 rfaD -2.2 -3.3 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b3792 wzxE -2.1 -6.6 O-antigen translocase (NCBI) compare
b0903 pflB -2.1 -11.4 pyruvate formate lyase I (NCBI) compare
b1575 dicB -2.1 -2.0 Qin prophage; cell division inhibition protein (NCBI) compare
b4701 sokX -2.1 -1.4 sok-related sRNA, function unknown (RefSeq) compare
b1855 lpxM -2.1 -5.8 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b3636 rpmG -2.1 -2.3 50S ribosomal protein L33 (NCBI) compare
b3632 rfaQ -2.1 -14.7 lipopolysaccharide core biosynthesis protein (NCBI) compare
b0462 acrB -2.1 -13.2 multidrug efflux system protein (NCBI) compare
b0688 pgm -2.1 -3.6 phosphoglucomutase (NCBI) compare
b0463 acrA -2.0 -9.9 multidrug efflux system (NCBI) compare
b3631 rfaG -2.0 -11.2 glucosyltransferase I (NCBI) compare
b3778 rep -2.0 -6.4 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b3052 rfaE -2.0 -4.4 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b0142 folK -2.0 -0.9 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b3842 rfaH -1.9 -5.7 transcriptional activator RfaH (NCBI) compare
b3630 rfaP -1.9 -7.2 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b1863 ruvC -1.9 -1.8 Holliday junction resolvase (NCBI) compare
b0386 proC -1.9 -4.1 pyrroline-5-carboxylate reductase (NCBI) compare
b2528 iscA -1.9 -2.1 iron-sulfur cluster assembly protein (NCBI) compare
b4025 pgi -1.8 -7.6 glucose-6-phosphate isomerase (NCBI) compare
b0178 hlpA -1.8 -4.5 periplasmic chaperone (NCBI) compare
b0049 apaH -1.8 -2.9 diadenosinetetraphosphatase (NCBI) compare
b0881 clpS -1.8 -2.3 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b4509 ylcG -1.8 -2.0 DLP12 prophage; predicted protein (NCBI) compare
b1334 fnr -1.8 -2.3 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b4520 ymgF -1.7 -1.6 hypothetical protein (NCBI) compare
b3163 nlpI -1.7 -4.4 hypothetical protein (NCBI) compare
b0239 frsA -1.7 -8.5 fermentation/respiration switch protein (NCBI) compare
b1882 cheY -1.7 -0.8 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b1530 marR -1.7 -3.9 multiple antibiotic resistance protein; repressor of mar operon (VIMSS) compare
b3194 yrbE -1.7 -9.2 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1103 ycfF -1.6 -1.3 orf, hypothetical protein (VIMSS) compare
b0728 sucC -1.6 -5.9 succinyl-CoA synthetase subunit beta (NCBI) compare
b0990 cspG -1.6 -1.3 DNA-binding transcriptional regulator (NCBI) compare
b3387 dam -1.6 -8.7 DNA adenine methylase (NCBI) compare
b3390 aroK -1.6 -2.1 shikimate kinase I (NCBI) compare
b2346 vacJ -1.5 -6.6 predicted lipoprotein (NCBI) compare
b0542 renD -1.5 -2.2 orf, hypothetical protein (VIMSS) compare
b3405 ompR -1.5 -4.2 osmolarity response regulator (NCBI) compare
b0949 uup -1.5 -6.0 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b3839 tatC -1.5 -5.6 TatABCE protein translocation system subunit (NCBI) compare
b3930 menA -1.5 -10.5 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b2188 yejM -1.5 -7.8 predicted hydrolase, inner membrane (NCBI) compare
b0706 ybfD -1.4 -1.4 hypothetical protein (NCBI) compare
b3192 yrbC -1.4 -8.1 predicted ABC-type organic solvent transporter (NCBI) compare
b1591 b1591 -1.4 -1.8 putative oxidoreductase component (VIMSS) compare
b1861 ruvA -1.4 -0.9 Holliday junction DNA helicase motor protein (NCBI) compare
b0677 nagA -1.4 -4.9 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b0957 ompA -1.4 -2.8 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b4699 fnrS -1.4 -1.0 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b1400 paaY -1.4 -2.4 predicted hexapeptide repeat acetyltransferase (NCBI) compare
b0145 dksA -1.4 -2.5 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b4535 yniD -1.4 -1.2 predicted protein (RefSeq) compare
b2189 proL -1.4 -1.8 tRNA-Pro (NCBI) compare
b1476 fdnI -1.4 -1.2 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b3193 yrbD -1.4 -7.4 predicted ABC-type organic solvent transporter (NCBI) compare
b3838 tatB -1.4 -6.5 sec-independent translocase (NCBI) compare
b3195 yrbF -1.3 -7.4 predicted toluene transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b1556 b1556 -1.3 -2.1 orf, hypothetical protein (VIMSS) compare
b0740 tolB -1.3 -3.1 translocation protein TolB precursor (NCBI) compare
b4503 yafF -1.3 -0.8 no description compare
b0784 moaD -1.3 -1.5 molybdopterin synthase, small subunit (NCBI) compare
b1304 pspA -1.3 -3.1 regulatory protein for phage-shock-protein operon (NCBI) compare
b0739 tolA -1.3 -2.2 cell envelope integrity inner membrane protein TolA (NCBI) compare
b0737 tolQ -1.2 -1.8 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2215 ompC -1.2 -5.6 outer membrane porin protein C (NCBI) compare
b0781 moaA -1.2 -6.8 molybdenum cofactor biosynthesis protein A (NCBI) compare
b2567 rnc -1.2 -0.8 ribonuclease III (NCBI) compare
b1600 mdtJ -1.2 -1.3 multidrug efflux system transporter (NCBI) compare
b2571 rseB -1.2 -5.9 periplasmic negative regulator of sigmaE (NCBI) compare
b1332 ynaJ -1.2 -0.7 predicted inner membrane protein (NCBI) compare
b1942 fliJ -1.2 -1.3 flagellar biosynthesis chaperone (NCBI) compare
b0009 mog -1.2 -6.0 molybdenum cofactor biosynthesis protein (NCBI) compare
b2894 xerD -1.2 -0.8 site-specific tyrosine recombinase XerD (NCBI) compare
b2064 asmA -1.2 -3.5 predicted assembly protein (NCBI) compare
b2912 ygfA -1.2 -2.8 putative ligase (VIMSS) compare
b1176 minC -1.2 -1.9 septum formation inhibitor (NCBI) compare
b2935 tktA -1.2 -0.8 transketolase 1, thiamin-binding (NCBI) compare
b0014 dnaK -1.2 -1.5 molecular chaperone DnaK (NCBI) compare
b3627 rfaI -1.2 -5.7 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b0827 moeA -1.2 -4.0 molybdopterin biosynthesis protein (NCBI) compare
b4631 ykgQ -1.2 -1.8 no description compare
b2509 xseA -1.2 -4.8 exodeoxyribonuclease VII large subunit (NCBI) conserved
b0232 yafN -1.2 -0.7 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b0730 mngR -1.1 -1.3 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b4426 isrA -1.1 -1.5 unknown RNA (NCBI) compare
b2330 yfcB -1.1 -1.3 putative adenine-specific methylase (VIMSS) compare
b1961 dcm -1.1 -1.8 DNA cytosine methylase (NCBI) compare
b4676 yoaK -1.1 -0.7 expressed protein (RefSeq) compare
b1726 yniB -1.1 -2.0 predicted inner membrane protein (NCBI) compare
b4042 dgkA -1.1 -1.8 diacylglycerol kinase (NCBI) compare
b1361 ydaW -1.1 -0.7 orf, hypothetical protein (VIMSS) compare
b4053 alr -1.1 -6.2 alanine racemase (NCBI) compare
b3191 yrbB -1.1 -5.8 orf, hypothetical protein (VIMSS) compare
b0564 appY -1.1 -1.0 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b3398 yrfF -1.1 -2.8 predicted inner membrane protein (NCBI) compare
b3628 rfaB -1.1 -5.4 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b4177 purA -1.1 -0.7 adenylosuccinate synthetase (NCBI) compare
b2820 recB -1.1 -0.7 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b3229 sspA -1.1 -2.1 stringent starvation protein A (NCBI) compare
b1604 ydgH -1.1 -4.3 hypothetical protein (NCBI) compare
b0364 yaiS -1.1 -2.2 orf, hypothetical protein (VIMSS) compare
b0785 moaE -1.1 -2.7 molybdopterin synthase, large subunit (NCBI) compare
b1506 yneL -1.1 -0.7 predicted transcriptional regulator (NCBI) compare
b0623 cspE -1.0 -1.8 cold shock protein E (NCBI) compare
b0729 sucD -1.0 -2.6 succinyl-CoA synthetase subunit alpha (NCBI) compare
b1527 yneK -1.0 -1.3 hypothetical protein (NCBI) compare
b0149 mrcB -1.0 -7.3 penicillin-binding protein 1b (NCBI) compare
b1259 yciG -1.0 -1.3 orf, hypothetical protein (VIMSS) compare
b2369 evgA -1.0 -1.8 DNA-binding response regulator in two-component regulatory system with EvgS (NCBI) compare
b1799 yeaT -1.0 -3.0 putative transcriptional regulator LYSR-type (VIMSS) compare
b4410 ecnA -1.0 -1.3 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b2494 yfgC -1.0 -4.6 predicted peptidase (NCBI) compare
b3836 b3836 -1.0 -3.3 orf, hypothetical protein (VIMSS) compare
b0783 moaC -1.0 -3.7 molybdenum cofactor biosynthesis protein C (NCBI) compare
b4294 insA-7 -1.0 -1.7 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b3726 pstA -1.0 -2.9 phosphate transporter subunit (NCBI) compare
b0741 pal -1.0 -2.3 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b1730 ydjO -1.0 -0.6 predicted protein (RefSeq) compare
b0406 tgt -1.0 -4.2 queuine tRNA-ribosyltransferase (NCBI) compare
b3916 pfkA -1.0 -1.4 6-phosphofructokinase (NCBI) compare
b3609 secB -1.0 -2.8 export protein SecB (NCBI) compare
b0763 modA -1.0 -3.5 molybdate transporter subunit (NCBI) compare
b3784 rfe -1.0 -6.6 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b2572 rseA -1.0 -4.1 anti-sigma factor (NCBI) compare
b2025 hisF -1.0 -3.0 imidazole glycerol phosphate synthase subunit HisF (NCBI) compare
b1175 minD -1.0 -3.1 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b1874 cutC -1.0 -1.9 copper homeostasis protein (NCBI) compare
b0200 gmhB -0.9 -0.8 hypothetical protein (NCBI) compare
b0357 yaiN -0.9 -1.7 putative alpha helix chain (VIMSS) compare
b1841 yobA -0.9 -1.6 hypothetical protein (NCBI) compare
b3935 priA -0.9 -2.0 primosome assembly protein PriA (NCBI) compare
b2784 relA -0.9 -5.5 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b3478 nikC -0.9 -5.8 nickel transporter subunit (NCBI) compare
b2620 smpB -0.9 -1.0 SsrA-binding protein (NCBI) compare
b0436 tig -0.9 -4.9 trigger factor (NCBI) compare
b3857 mobA -0.9 -3.6 molybdopterin-guanine dinucleotide biosynthesis protein A (NCBI) compare
b2699 recA -0.9 -0.6 recombinase A (NCBI) compare
b1951 rcsA -0.9 -0.6 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b1108 ycfP -0.9 -2.3 orf, hypothetical protein (VIMSS) compare
b4239 treC -0.9 -1.3 trehalose-6-P hydrolase (NCBI) compare
b1823 cspC -0.9 -1.4 stress protein, member of the CspA-family (NCBI) compare
b1644 b1644 -0.9 -2.6 putative membrane protein (VIMSS) compare
b3183 obgE -0.9 -0.8 GTPase involved in cell partioning and DNA repair (NCBI) compare
b2954 yggV -0.9 -2.8 putative deoxyribonucleotide triphosphate pyrophosphatase (NCBI) compare
b4702 mgtL -0.9 -1.4 regulatory leader peptide for mgtA (NCBI) compare
b0630 lipB -0.9 -1.1 protein of lipoate biosynthesis (VIMSS) compare
b0761 modE -0.9 -4.4 DNA-binding transcriptional dual regulator (NCBI) compare
b0535 fimZ -0.9 -1.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b1877 yecT -0.9 -1.1 orf, hypothetical protein (VIMSS) compare
b1831 proQ -0.9 -2.8 putative solute/DNA competence effector (NCBI) compare
b3414 gntY -0.9 -3.4 predicted gluconate transport associated protein (NCBI) compare
b1195 ymgE -0.9 -2.2 predicted inner membrane protein (NCBI) compare
b0764 modB -0.9 -3.3 molybdate ABC transporter permease protein (NCBI) compare
b0018 mokC -0.9 -1.0 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b1579 intQ -0.9 -1.1 Qin prophage; predicted defective integrase (RefSeq) compare
b4146 yjeK -0.8 -1.0 predicted lysine aminomutase (NCBI) compare
b3026 qseC -0.8 -1.7 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b2181 yejG -0.8 -2.8 hypothetical protein (NCBI) compare
b1382 ynbE -0.8 -1.1 predicted lipoprotein (NCBI) compare
b4202 rpsR -0.8 -0.8 30S ribosomal protein S18 (NCBI) compare
b3790 rffC -0.8 -2.9 TDP-fucosamine acetyltransferase (RefSeq) compare
b0826 moeB -0.8 -3.4 molybdopterin biosynthesis protein MoeB (NCBI) compare
b0547 ybcN -0.8 -2.6 DLP12 prophage; predicted protein (NCBI) compare
b2997 hybO -0.8 -4.1 hydrogenase 2, small subunit (NCBI) compare
b4594 ymgJ -0.8 -1.4 hypothetical protein (RefSeq) compare
b0645 ybeR -0.8 -3.2 hypothetical protein (NCBI) compare
b2576 srmB -0.8 -1.7 ATP-dependent RNA helicase (NCBI) compare
b0802 ybiJ -0.8 -1.4 hypothetical protein (NCBI) compare
b2051 wcaH -0.8 -1.4 GDP-mannose mannosyl hydrolase (VIMSS) compare
b3870 glnA -0.8 -1.7 glutamine synthetase (NCBI) compare
b1749 xthA -0.8 -2.3 exonuclease III (NCBI) compare
b2274 yfbO -0.8 -2.5 predicted protein (RefSeq) compare
b1192 ldcA -0.8 -3.1 L,D-carboxypeptidase A (NCBI) compare
b0738 tolR -0.8 -1.5 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2284 nuoF -0.8 -2.8 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b1536 ydeI -0.8 -0.5 hypothetical protein (NCBI) compare
b3476 nikA -0.8 -4.5 nickel transporter subunit (NCBI) compare
b3963 fabR -0.8 -5.3 DNA-binding transcriptional repressor (RefSeq) compare
b1291 sapD -0.8 -1.0 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1049 mdoH -0.8 -4.2 glucosyltransferase MdoH (NCBI) compare
b1196 ycgY -0.8 -1.3 hypothetical protein (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress Nalidixic acid sodium salt across organisms