Experiment set10IT081 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Azlocillin sodium salt 0.00003125 mM

200 most detrimental genes:

  gene name fitness t score description  
b2096 gatY +1.7 8.7 tagatose-bisphosphate aldolase 1 (VIMSS) compare
b2259 pmrD +1.6 2.3 polymyxin resistance protein B (VIMSS) compare
b1429 tehA +1.6 2.2 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b3375 yhfR +1.3 8.6 putative transcriptional regulator (VIMSS) compare
b2419 yfeK +1.2 3.2 hypothetical protein (NCBI) compare
b2279 nuoK +1.1 1.9 NADH dehydrogenase subunit K (NCBI) compare
b1307 pspD +1.0 2.4 peripheral inner membrane phage-shock protein (NCBI) compare
b1548 nohA +1.0 2.2 Qin prophage; predicted packaging protein (RefSeq) compare
b2095 gatZ +0.9 4.5 D-tagatose 1,6-bisphosphate aldolase 2, subunit (NCBI) compare
b2092 gatC +0.9 4.3 galactitol-specific enzyme IIC component of PTS (NCBI) compare
b1332 ynaJ +0.9 0.8 predicted inner membrane protein (NCBI) compare
b4692 oweE +0.9 2.5 no description compare
b1289 ycjD +0.8 3.1 hypothetical protein (NCBI) compare
b2424 cysU +0.8 1.8 sulfate/thiosulfate transporter subunit (NCBI) compare
b4246 pyrL +0.8 1.7 pyrBI operon leader peptide (NCBI) compare
b2195 ccmG +0.8 2.2 periplasmic thioredoxin of cytochrome c-type biogenesis (NCBI) compare
b2897 ygfY +0.8 2.8 hypothetical protein (NCBI) compare
b0965 b0965 +0.7 2.3 orf, hypothetical protein (VIMSS) compare
b1627 rsxA +0.7 2.6 Na(+)-translocating NADH-quinone reductase subunit E (NCBI) compare
b1853 yebK +0.7 2.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b0219 yafV +0.7 2.7 predicted C-N hydrolase family amidase, NAD(P)-binding (NCBI) compare
b1134 ymfB +0.7 1.7 bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase (NCBI) compare
b0753 ybgS +0.7 3.2 hypothetical protein (NCBI) compare
b2061 wzb +0.7 1.7 protein-tyrosine phosphatase (NCBI) compare
b1524 yneH +0.7 0.8 predicted glutaminase (NCBI) compare
b2287 nuoB +0.7 2.4 NADH dehydrogenase subunit B (NCBI) compare
b2432 yfeY +0.7 1.8 hypothetical protein (NCBI) compare
b1615 uidC +0.7 2.3 membrane-associated protein (VIMSS) compare
b1070 flgN +0.7 1.2 export chaperone for FlgK and FlgL (NCBI) compare
b0713 ybgL +0.7 3.5 hypothetical protein (NCBI) compare
b1086 rluC +0.7 2.8 23S rRNA pseudouridylate synthase (NCBI) compare
b0249 ykfF +0.7 1.9 CP4-6 prophage; predicted protein (NCBI) compare
b1558 cspF +0.7 0.8 Qin prophage; cold shock protein (NCBI) compare
b3860 dsbA +0.7 4.4 periplasmic protein disulfide isomerase I (NCBI) compare
b1476 fdnI +0.7 0.9 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b1360 ydaV +0.7 2.5 Rac prophage; predicted DNA replication protein (NCBI) compare
b4631 ykgQ +0.6 1.6 no description compare
b3890 yiiF +0.6 1.8 orf, hypothetical protein (VIMSS) compare
b3398 yrfF +0.6 2.3 predicted inner membrane protein (NCBI) compare
b1251 yciI +0.6 2.1 orf, hypothetical protein (VIMSS) compare
b0624 crcB +0.6 2.1 camphor resistance protein CrcB (NCBI) compare
b0793 ybhS +0.6 3.4 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1632 rsxE +0.6 2.8 NADH-ubiquinone oxidoreductase (NCBI) compare
b2093 gatB +0.6 1.5 galactitol-specific enzyme IIB component of PTS (NCBI) compare
b1446 ydcY +0.6 0.9 hypothetical protein (NCBI) compare
b1412 azoR +0.6 1.7 acyl carrier protein phosphodiesterase (NCBI) compare
b2783 chpR +0.6 1.2 antitoxin of the ChpA-ChpR toxin-antitoxin system (NCBI) compare
b2904 gcvH +0.6 1.6 glycine cleavage system protein H (NCBI) compare
b1349 recT +0.6 2.4 Rac prophage; recombination and repair protein (NCBI) compare
b1034 ycdX +0.6 2.4 hypothetical protein (NCBI) compare
b2953 yggU +0.6 0.7 orf, hypothetical protein (VIMSS) compare
b2080 b2080 +0.6 1.3 orf, hypothetical protein (VIMSS) compare
b1811 yoaH +0.6 1.9 hypothetical protein (NCBI) compare
b0471 ybaB +0.6 1.4 hypothetical protein (NCBI) compare
b4538 yoeF +0.6 0.8 hypothetical protein (RefSeq) compare
b2646 ypjF +0.6 1.6 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b2448 yffQ +0.6 1.3 CPZ-55 prophage; predicted protein (RefSeq) compare
b2708 gutQ +0.6 2.7 orf, hypothetical protein (VIMSS) compare
b0250 ykfB +0.5 2.2 CP4-6 prophage; predicted protein (NCBI) compare
b1253 yciA +0.5 1.9 predicted hydrolase (NCBI) compare
b1180 ycgM +0.5 2.1 predicted isomerase/hydrolase (NCBI) compare
b0943 b0943 +0.5 2.9 putative fimbrial-like protein (VIMSS) compare
b2183 rsuA +0.5 1.4 16S rRNA pseudouridylate 516 synthase (NCBI) compare
b2094 gatA +0.5 2.3 galactitol-specific enzyme IIA component of PTS (NCBI) compare
b0963 mgsA +0.5 2.9 methylglyoxal synthase (VIMSS) compare
b1090 plsX +0.5 2.6 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b1266 yciV +0.5 1.4 hypothetical protein (NCBI) compare
b1151 ymfO +0.5 1.7 e14 prophage; conserved protein (RefSeq) compare
b4642 yoeD +0.5 1.8 no description compare
b0802 ybiJ +0.5 1.5 hypothetical protein (NCBI) compare
b0147 yadP +0.5 3.4 orf, hypothetical protein (VIMSS) compare
b1171 b1171 +0.5 1.2 orf, hypothetical protein (VIMSS) compare
b2674 nrdI +0.5 2.2 hypothetical protein (NCBI) compare
b2319 usg +0.5 1.9 hypothetical protein (NCBI) compare
b1617 uidA +0.5 2.3 beta-D-glucuronidase (NCBI) compare
b2209 eco +0.5 1.3 ecotin precursor (NCBI) compare
b2990 hybG +0.5 1.1 hydrogenase 2 accessory protein (NCBI) compare
b1443 ydcV +0.5 1.7 predicted spermidine/putrescine transporter subunit (NCBI) compare
b1415 aldA +0.5 2.2 Lactaldehyde / glycolaldehyde dehydrogenase aldA (EC 1.2.1.22; EC 1.2.1.21) (from data) compare
b3348 slyX +0.5 1.8 hypothetical protein (NCBI) compare
b1959 yedA +0.5 1.9 predicted inner membrane protein (NCBI) compare
b2905 gcvT +0.5 2.7 glycine cleavage system aminomethyltransferase T (NCBI) compare
b3148 yraN +0.5 1.7 hypothetical protein (NCBI) compare
b1045 ymdB +0.5 2.1 hypothetical protein (NCBI) compare
b1630 rsxD +0.5 2.0 electron transport complex protein RnfD (NCBI) compare
b2906 visC +0.5 2.4 hypothetical protein (NCBI) compare
b0418 pgpA +0.5 2.2 phosphatidylglycerophosphatase A (NCBI) compare
b3101 yqjF +0.5 0.9 orf, hypothetical protein (VIMSS) compare
b1438 ydcQ +0.5 1.5 predicted DNA-binding transcriptional regulator (RefSeq) compare
b0907 serC +0.5 1.9 phosphoserine aminotransferase (NCBI) compare
b2807 ygdD +0.5 2.0 conserved inner membrane protein (NCBI) compare
b3024 ygiW +0.5 1.9 hypothetical protein (NCBI) compare
b0627 tatE +0.5 1.0 twin arginine translocase protein E (NCBI) compare
b1382 ynbE +0.5 0.9 predicted lipoprotein (NCBI) compare
b4484 cpxP +0.5 2.1 periplasmic protein combats stress (NCBI) compare
b0778 bioD +0.5 1.8 dethiobiotin synthetase (NCBI) compare
b4656 yjhY +0.5 1.9 no description compare
b1656 sodB +0.5 1.4 superoxide dismutase, Fe (NCBI) compare
b2023 hisH +0.5 2.0 imidazole glycerol phosphate synthase subunit HisH (NCBI) compare
b4598 yncL +0.4 1.1 hypothetical protein (RefSeq) compare
b2217 rcsB +0.4 2.2 DNA-binding response regulator in two-component regulatory system with RcsC and YojN (NCBI) compare
b1556 b1556 +0.4 0.9 orf, hypothetical protein (VIMSS) compare
b1963 b1963 +0.4 1.8 orf, hypothetical protein (VIMSS) compare
b1563 relE +0.4 0.8 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b1962 yedJ +0.4 1.8 predicted phosphohydrolase (NCBI) compare
b4241 treR +0.4 3.3 trehalose repressor (NCBI) compare
b4561 insM +0.4 1.5 transposase (RefSeq) compare
b1954 dsrA +0.4 0.9 regulatory antisense RNA (NCBI) compare
b1942 fliJ +0.4 0.5 flagellar biosynthesis chaperone (NCBI) compare
b1185 dsbB +0.4 1.2 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b2314 dedD +0.4 1.6 putative lipoprotein (VIMSS) compare
b1931 yedK +0.4 1.7 hypothetical protein (NCBI) compare
b1841 yobA +0.4 0.9 hypothetical protein (NCBI) compare
b2007 yeeX +0.4 1.5 conserved protein (RefSeq) compare
b2301 yfcF +0.4 1.8 predicted enzyme (NCBI) compare
b3723 bglG +0.4 1.4 transcriptional antiterminator of the bgl operon (NCBI) compare
b3120 yhaB +0.4 0.7 orf, hypothetical protein (VIMSS) compare
b2439 eutL +0.4 2.0 predicted carboxysome structural protein with predicted role in ethanolamine utilization (NCBI) compare
b1577 ydfE +0.4 2.0 Qin prophage; predicted protein (RefSeq) compare
b3977 tyrU +0.4 0.4 tRNA-Tyr (NCBI) compare
b2969 yghE +0.4 1.1 predicted secretion pathway protein, L-type protein (pseudogene) (RefSeq) compare
b4416 rybA +0.4 0.7 unknown RNA (NCBI) compare
b0655 gltI +0.4 1.6 glutamate and aspartate transporter subunit (NCBI) compare
b2711 norW +0.4 2.2 nitric oxide reductase (NCBI) compare
b1738 chbB +0.4 1.9 N,N'-diacetylchitobiose-specific enzyme IIB component of PTS (NCBI) compare
b1074 flgC +0.4 1.0 flagellar basal-body rod protein C (NCBI) compare
b1747 astA +0.4 1.9 arginine succinyltransferase (NCBI) compare
b4453 ldrD +0.4 0.7 toxic polypeptide, small (NCBI) compare
b2618 b2618 +0.4 1.0 orf, hypothetical protein (VIMSS) compare
b3911 cpxA +0.4 2.8 two-component sensor protein (NCBI) compare
b1867 yecD +0.4 1.9 orf, hypothetical protein (VIMSS) compare
b3950 frwB +0.4 1.1 predicted enzyme IIB component of PTS (NCBI) compare
b2506 yfgI +0.4 0.8 hypothetical protein (NCBI) compare
b1269 rluB +0.4 1.3 23S rRNA pseudouridylate synthase (NCBI) compare
b0995 torR +0.4 1.8 DNA-binding response regulator in two-component regulatory system with TorS (NCBI) compare
b2722 hycD +0.4 1.8 hydrogenase 3, membrane subunit (NCBI) compare
b4406 yaeP +0.4 0.8 hypothetical protein (NCBI) compare
b2050 wcaI +0.4 1.6 predicted glycosyl transferase (NCBI) compare
b3181 greA +0.4 1.7 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b0430 cyoC +0.4 1.4 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b3728 pstS +0.4 1.0 phosphate transporter subunit (NCBI) compare
b1244 oppB +0.4 2.3 oligopeptide permease ABC transporter membrane protein (NCBI) compare
b0752 zitB +0.4 1.6 zinc transporter ZitB (NCBI) compare
b1312 ycjP +0.4 2.1 predicted sugar transporter subunit: membrane component of ABC superfamily (NCBI) compare
b3555 yiaG +0.4 1.3 predicted transcriptional regulator (NCBI) compare
b1143 ymfI +0.4 0.6 orf, hypothetical protein (VIMSS) compare
b1821 b1821 +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b0977 hyaF +0.4 1.0 protein involved in nickel incorporation into hydrogenase-1 proteins (NCBI) compare
b2725 hycA +0.4 1.7 regulator of the transcriptional regulator FhlA (NCBI) compare
b0661 miaB +0.4 2.2 isopentenyl-adenosine A37 tRNA methylthiolase (NCBI) compare
b1612 fumA +0.4 1.3 fumarate hydratase (fumarase A), aerobic Class I (NCBI) compare
b1372 b1372 +0.4 2.1 putative membrane protein (VIMSS) compare
b4490 efeU +0.4 2.3 no description compare
b2676 nrdF +0.4 1.6 ribonucleotide-diphosphate reductase beta subunit (NCBI) compare
b1587 ynfE +0.4 2.0 oxidoreductase subunit (NCBI) compare
b2349 intS +0.4 1.9 CPS-53 (KpLE1) prophage; predicted prophage CPS-53 integrase (NCBI) compare
b2398 yfeC +0.4 1.5 orf, hypothetical protein (VIMSS) compare
b2342 yfcY +0.4 1.9 acetyl-CoA acetyltransferase (NCBI) compare
b2634 yfjR +0.4 1.1 CP4-57 prophage; predicted DNA-binding transcriptional regulator (NCBI) compare
b2476 purC +0.4 1.0 phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) compare
b2276 nuoN +0.4 1.4 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b4050 yjbO +0.4 1.5 orf, hypothetical protein (VIMSS) compare
b0758 galT +0.4 1.7 galactose-1-phosphate uridylyltransferase (NCBI) compare
b0604 dsbG +0.4 1.9 thiol:disulfide interchange protein (VIMSS) compare
b2300 yfcE +0.4 1.2 orf, hypothetical protein (VIMSS) compare
b1411 ynbD +0.4 1.3 predicted phosphatase, inner membrane protein (NCBI) compare
b0708 phr +0.4 2.0 deoxyribodipyrimidine photolyase, FAD-binding (NCBI) compare
b1725 yniA +0.4 1.9 predicted phosphotransferase/kinase (NCBI) compare
b4301 sgcE +0.4 1.8 ribulose-phosphate 3-epimerase (NCBI) compare
b3881 yihT +0.4 2.1 predicted aldolase (NCBI) compare
b1697 ydiQ +0.4 1.4 hypothetical protein (NCBI) compare
b0405 queA +0.4 1.5 S-adenosylmethionine:tRNA ribosyltransferase-isomerase (NCBI) compare
b2298 yfcC +0.4 2.3 putative S-transferase (VIMSS) compare
b1640 ydhH +0.4 1.3 anhydro-N-acetylmuramic acid kinase (NCBI) compare
b2782 chpA +0.4 1.4 toxin of the ChpA-ChpR toxin-antitoxin system, endoribonuclease (NCBI) compare
b2145 yeiS +0.4 1.2 predicted inner membrane protein (NCBI) compare
b4099 phnI +0.4 2.3 carbon-phosphorus lyase complex subunit (NCBI) compare
b0520 ylbF +0.4 1.4 hypothetical protein (NCBI) compare
b0495 ybbA +0.4 1.3 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b1745 astB +0.4 1.8 succinylarginine dihydrolase (NCBI) compare
b0772 ybhC +0.4 2.5 predicted pectinesterase (NCBI) compare
b1359 ydaU +0.4 1.0 Rac prophage; conserved protein (NCBI) compare
b2395 yfeA +0.4 2.5 orf, hypothetical protein (VIMSS) compare
b2431 b2431 +0.4 1.9 orf, hypothetical protein (VIMSS) compare
b1922 fliA +0.4 1.8 flagellar biosynthesis; alternative sigma factor 28; regulation of flagellar operons (VIMSS) compare
b2785 rumA +0.4 2.4 23S rRNA (uracil-5-)-methyltransferase (NCBI) compare
b0148 hrpB +0.4 2.8 helicase, ATP-dependent (VIMSS) compare
b2199 ccmC +0.3 1.5 heme exporter subunit (NCBI) compare
b1586 b1586 +0.3 1.3 orf, hypothetical protein (VIMSS) compare
b2450 yffS +0.3 0.6 CPZ-55 prophage; predicted protein (RefSeq) compare
b4407 thiS +0.3 0.8 sulfur carrier protein ThiS (NCBI) compare
b1323 tyrR +0.3 1.6 DNA-binding transcriptional dual regulator, tyrosine-binding (NCBI) compare
b0972 hyaA +0.3 1.9 hydrogenase 1, small subunit (NCBI) compare
b1285 gmr +0.3 1.7 modulator of Rnase II stability (NCBI) compare
b0678 nagB +0.3 1.3 glucosamine-6-phosphate deaminase (NCBI) compare
b0850 ybjC +0.3 0.9 predicted inner membrane protein (NCBI) compare
b3161 mtr +0.3 2.3 tryptophan transporter of high affinity (NCBI) compare
b1337 abgB +0.3 1.2 predicted peptidase, aminobenzoyl-glutamate utilization protein (NCBI) compare
b4144 yjeI +0.3 1.5 orf, hypothetical protein (VIMSS) compare
b1704 aroH +0.3 1.2 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible (NCBI) compare


Specific Phenotypes

For 4 genes in this experiment

For stress Azlocillin sodium salt in Escherichia coli BW25113

For stress Azlocillin sodium salt across organisms