Experiment set10IT071 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Norfloxacin 0.00000015625 mM

200 most detrimental genes:

  gene name fitness t score description  
b0929 ompF +3.0 17.0 outer membrane porin 1a (Ia;b;F) (NCBI) compare
b3405 ompR +2.1 10.9 osmolarity response regulator (NCBI) compare
b3860 dsbA +1.9 14.0 periplasmic protein disulfide isomerase I (NCBI) compare
b1185 dsbB +1.8 4.8 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b0178 hlpA +1.7 7.5 periplasmic chaperone (NCBI) compare
b1613 manA +1.5 2.8 mannose-6-phosphate isomerase (VIMSS) compare
b2572 rseA +1.5 5.1 anti-sigma factor (NCBI) compare
b2617 smpA +1.4 5.2 small membrane protein A (VIMSS) compare
b2512 yfgL +1.3 7.5 protein assembly complex, lipoprotein component (NCBI) compare
b4693 aaaE +1.3 6.8 no description compare
b1148 ymfM +1.3 4.8 e14 prophage; predicted protein (NCBI) compare
b3181 greA +1.3 6.3 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b1231 tyrT +1.3 1.7 tRNA-Tyr (NCBI) compare
b0464 acrR +1.3 9.0 DNA-binding transcriptional repressor (NCBI) compare
b4699 fnrS +1.2 1.6 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b1152 ymfP +1.2 5.5 orf, hypothetical protein (VIMSS) compare
b4066 yjcF +1.2 1.0 hypothetical protein (NCBI) compare
b1524 yneH +1.1 1.4 predicted glutaminase (NCBI) compare
b1349 recT +1.0 6.2 Rac prophage; recombination and repair protein (NCBI) compare
b1684 sufA +1.0 3.1 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b3791 rffA +1.0 6.3 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b1157 stfE +1.0 4.1 no description compare
b2259 pmrD +1.0 1.3 polymyxin resistance protein B (VIMSS) compare
b1217 chaB +1.0 1.4 cation transport regulator (NCBI) compare
b1920 fliY +1.0 1.9 cystine transporter subunit (NCBI) compare
b1048 mdoG +1.0 5.1 glucan biosynthesis protein, periplasmic (NCBI) compare
b4692 oweE +1.0 3.4 no description compare
b2571 rseB +0.9 5.8 periplasmic negative regulator of sigmaE (NCBI) compare
b0418 pgpA +0.9 4.1 phosphatidylglycerophosphatase A (NCBI) compare
b2061 wzb +0.9 2.3 protein-tyrosine phosphatase (NCBI) compare
b1187 fadR +0.9 2.4 fatty acid metabolism regulator (NCBI) compare
b1104 ycfL +0.9 1.7 hypothetical protein (NCBI) compare
b3706 trmE +0.9 3.4 tRNA modification GTPase (NCBI) compare
b1821 b1821 +0.8 2.4 orf, hypothetical protein (VIMSS) compare
b1850 eda +0.8 2.5 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b3026 qseC +0.8 2.7 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b1154 ycfK +0.8 5.0 e14 prophage; predicted protein (NCBI) compare
b0946 ycbW +0.8 3.2 orf, hypothetical protein (VIMSS) compare
b1446 ydcY +0.8 1.7 hypothetical protein (NCBI) compare
b1855 lpxM +0.8 3.8 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b1563 relE +0.8 1.7 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b4503 yafF +0.8 0.8 no description compare
b0806 ybiM +0.8 2.6 orf, hypothetical protein (VIMSS) compare
b4533 ynfO +0.8 1.8 Qin prophage; predicted protein (NCBI) compare
b1627 rsxA +0.8 2.4 Na(+)-translocating NADH-quinone reductase subunit E (NCBI) compare
b2518 ndk +0.8 2.0 nucleoside diphosphate kinase (NCBI) compare
b3162 deaD +0.8 3.3 inducible ATP-independent RNA helicase (VIMSS) compare
b1926 fliT +0.8 3.1 predicted chaperone (NCBI) compare
b1949 fliQ +0.8 2.1 flagellar biosynthesis protein Q (NCBI) compare
b2501 ppk +0.8 5.3 polyphosphate kinase (NCBI) compare
b1049 mdoH +0.7 5.2 glucosyltransferase MdoH (NCBI) compare
b0219 yafV +0.7 2.1 predicted C-N hydrolase family amidase, NAD(P)-binding (NCBI) compare
b1155 ymfS +0.7 2.5 e14 prophage; predicted protein (NCBI) compare
b4508 peaD +0.7 2.1 putative sensory transduction regulator (VIMSS) compare
b0580 ybdJ +0.7 2.0 predicted inner membrane protein (NCBI) compare
b0059 hepA +0.7 6.0 ATP-dependent helicase HepA (NCBI) compare
b2564 pdxJ +0.7 2.6 pyridoxal phosphate biosynthetic protein (NCBI) compare
b1582 ynfA +0.7 1.3 hypothetical protein (NCBI) compare
b2104 thiM +0.7 2.2 hydroxyethylthiazole kinase (NCBI) compare
b1151 ymfO +0.7 1.2 e14 prophage; conserved protein (RefSeq) compare
b1632 rsxE +0.7 3.6 NADH-ubiquinone oxidoreductase (NCBI) compare
b0200 gmhB +0.7 0.9 hypothetical protein (NCBI) compare
b4481 rffT +0.7 3.3 4-alpha-L-fucosyltransferase (NCBI) compare
b1144 ymfJ +0.7 1.9 orf, hypothetical protein (VIMSS) compare
b3205 yhbJ +0.7 2.6 hypothetical protein (NCBI) compare
b0247 ykfG +0.7 1.1 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b2193 narP +0.6 2.9 DNA-binding response regulator in two-component regulatory system with NarQ or NarX (NCBI) compare
b1143 ymfI +0.6 1.4 orf, hypothetical protein (VIMSS) compare
b3183 obgE +0.6 0.7 GTPase involved in cell partioning and DNA repair (NCBI) compare
b3790 rffC +0.6 3.1 TDP-fucosamine acetyltransferase (RefSeq) compare
b2708 gutQ +0.6 3.3 orf, hypothetical protein (VIMSS) compare
b2749 ygbE +0.6 3.2 conserved inner membrane protein (NCBI) compare
b1158 pin +0.6 2.7 e14 prophage; site-specific DNA recombinase (NCBI) compare
b3052 rfaE +0.6 2.6 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b1610 tus +0.6 3.1 DNA replication terminus site-binding protein (NCBI) compare
b1147 ymfL +0.6 1.7 e14 prophage; predicted DNA-binding transcriptional regulator (RefSeq) compare
b2940 yqgC +0.6 2.8 hypothetical protein (NCBI) compare
b1865 nudB +0.6 0.9 dATP pyrophosphohydrolase (NCBI) compare
b4241 treR +0.6 4.6 trehalose repressor (NCBI) compare
b1429 tehA +0.6 0.8 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b1161 ycgX +0.6 0.7 hypothetical protein (NCBI) compare
b0920 ycbC +0.6 2.3 conserved inner membrane protein (NCBI) compare
b4171 miaA +0.6 1.9 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b2236 yfaE +0.6 1.2 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b2947 gshB +0.6 2.2 glutathione synthetase (NCBI) compare
b1312 ycjP +0.6 3.1 predicted sugar transporter subunit: membrane component of ABC superfamily (NCBI) compare
b2058 wcaB +0.6 0.7 predicted acyl transferase (NCBI) compare
b1263 trpD +0.6 1.6 bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) compare
b2620 smpB +0.6 0.8 SsrA-binding protein (NCBI) compare
b1350 recE +0.6 3.5 Rac prophage; exonuclease VIII, 5' -> 3' specific dsDNA exonuclease (NCBI) compare
b3404 envZ +0.6 2.9 osmolarity sensor protein (NCBI) compare
b3673 emrD +0.6 4.4 2-module integral membrane pump; multidrug resistance (VIMSS) compare
b3751 rbsB +0.6 3.5 D-ribose transporter subunit (NCBI) compare
b1138 ymfE +0.6 1.1 e14 prophage; predicted inner membrane protein (NCBI) compare
b1853 yebK +0.6 1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b2051 wcaH +0.6 1.4 GDP-mannose mannosyl hydrolase (VIMSS) compare
b2953 yggU +0.6 1.5 orf, hypothetical protein (VIMSS) compare
b3728 pstS +0.6 1.6 phosphate transporter subunit (NCBI) compare
b2768 ygcP +0.5 1.3 predicted anti-terminator regulatory protein (NCBI) compare
b1846 yebE +0.5 2.2 hypothetical protein (NCBI) compare
b1584 speG +0.5 3.2 spermidine N1-acetyltransferase (NCBI) compare
b3630 rfaP +0.5 3.9 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b1728 ydjM +0.5 1.7 predicted inner membrane protein regulated by LexA (RefSeq) compare
b3009 yghB +0.5 2.9 conserved inner membrane protein (NCBI) compare
b4408 csrB +0.5 2.0 CsrA-binding sRNA, antagonizing CsrA regulation (NCBI) compare
b0677 nagA +0.5 2.7 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b0191 yaeJ +0.5 2.1 hypothetical protein (NCBI) compare
b4416 rybA +0.5 0.9 unknown RNA (NCBI) compare
b3071 yqjI +0.5 2.0 predicted transcriptional regulator (NCBI) compare
b1604 ydgH +0.5 2.3 hypothetical protein (NCBI) compare
b1699 ydiS +0.5 2.1 predicted oxidoreductase with FAD/NAD(P)-binding domain (NCBI) compare
b1423 ydcJ +0.5 1.4 hypothetical protein (NCBI) compare
b1782 mipA +0.5 2.3 scaffolding protein for murein synthesizing machinery (NCBI) compare
b1095 fabF +0.5 2.9 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b2261 menC +0.5 2.9 O-succinylbenzoate synthase (NCBI) compare
b1557 cspB +0.5 1.1 Qin prophage; cold shock protein (NCBI) compare
b3119 tdcR +0.5 0.9 threonine dehydratase operon activator protein (VIMSS) compare
b4484 cpxP +0.5 2.8 periplasmic protein combats stress (NCBI) compare
b0447 ybaO +0.5 2.2 putative LRP-like transcriptional regulator (VIMSS) compare
b0797 rhlE +0.5 2.8 RNA helicase (NCBI) compare
b4373 rimI +0.5 1.7 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b1438 ydcQ +0.5 1.9 predicted DNA-binding transcriptional regulator (RefSeq) compare
b4609 ryfD +0.5 1.7 Novel sRNA, function unknown (RefSeq) compare
b1139 lit +0.5 2.1 e14 prophage; cell death peptidase, inhibitor of T4 late gene expression (NCBI) compare
b1583 ynfB +0.5 1.2 hypothetical protein (NCBI) compare
b3631 rfaG +0.5 4.1 glucosyltransferase I (NCBI) compare
b2047 wcaJ +0.5 2.1 predicted UDP-glucose lipid carrier transferase (NCBI) compare
b1399 paaX +0.5 2.1 DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive (NCBI) compare
b2915 yqfE +0.5 1.4 hypothetical protein (RefSeq) compare
b1281 pyrF +0.5 1.8 orotidine 5'-phosphate decarboxylase (NCBI) compare
b0579 ybdF +0.5 1.8 hypothetical protein (NCBI) compare
b0125 hpt +0.5 2.4 hypoxanthine phosphoribosyltransferase (VIMSS) compare
b2082 ogrK +0.5 1.9 DNA-binding transcriptional regulator prophage P2 remnant (NCBI) compare
b2570 rseC +0.5 2.0 RseC protein involved in reduction of the SoxR iron-sulfur cluster (NCBI) compare
b1332 ynaJ +0.5 0.4 predicted inner membrane protein (NCBI) compare
b2939 yqgB +0.5 0.9 predicted protein (RefSeq) compare
b1153 ymfQ +0.5 1.1 e14 prophage; conserved protein (NCBI) compare
b0222 lpcA +0.5 1.3 phosphoheptose isomerase (NCBI) compare
b4402 yjjY +0.5 0.2 hypothetical protein (NCBI) compare
b2195 ccmG +0.5 1.4 periplasmic thioredoxin of cytochrome c-type biogenesis (NCBI) compare
b4552 yrhC +0.5 0.5 no description compare
b4529 ydbJ +0.5 0.6 hypothetical protein (NCBI) compare
b1384 feaR +0.5 2.8 DNA-binding transcriptional dual regulator (NCBI) compare
b0937 ssuE +0.5 1.2 NAD(P)H-dependent FMN reductase (NCBI) compare
b1811 yoaH +0.5 1.2 hypothetical protein (NCBI) compare
b2223 atoE +0.5 2.0 short chain fatty acid transporter (NCBI) compare
b3632 rfaQ +0.5 4.1 lipopolysaccharide core biosynthesis protein (NCBI) compare
b2661 gabD +0.5 2.7 succinate-semialdehyde dehydrogenase I, NADP-dependent (NCBI) compare
b0889 lrp +0.5 1.2 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b1915 yecF +0.5 2.4 hypothetical protein (NCBI) compare
b4011 yjaA +0.4 1.6 hypothetical protein (NCBI) compare
b1034 ycdX +0.4 1.9 hypothetical protein (NCBI) compare
b0405 queA +0.4 2.0 S-adenosylmethionine:tRNA ribosyltransferase-isomerase (NCBI) compare
b0250 ykfB +0.4 1.6 CP4-6 prophage; predicted protein (NCBI) compare
b2343 b2343 +0.4 0.9 orf, hypothetical protein (VIMSS) compare
b1642 slyA +0.4 1.1 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b1516 lsrB +0.4 1.9 AI2 transporter (NCBI) compare
b1792 yeaO +0.4 1.5 orf, hypothetical protein (VIMSS) compare
b0108 ppdD +0.4 1.8 predicted major pilin subunit (NCBI) compare
b4702 mgtL +0.4 0.8 regulatory leader peptide for mgtA (NCBI) compare
b0641 rlpB +0.4 1.2 minor lipoprotein (NCBI) compare
b1822 rrmA +0.4 1.6 23S rRNA m1G745 methyltransferase (NCBI) compare
b0965 b0965 +0.4 1.3 orf, hypothetical protein (VIMSS) compare
b1090 plsX +0.4 1.8 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b2535 csiE +0.4 3.1 orf, hypothetical protein (VIMSS) compare
b1780 yeaD +0.4 1.5 orf, hypothetical protein (VIMSS) compare
b3741 gidA +0.4 1.6 glucose-inhibited division protein A (NCBI) compare
b3817 yigF +0.4 2.3 conserved inner membrane protein (NCBI) compare
b2155 cirA +0.4 2.5 ferric iron-catecholate outer membrane transporter (NCBI) compare
b1842 holE +0.4 0.8 DNA polymerase III, theta subunit (NCBI) compare
b1685 ydiH +0.4 0.8 predicted protein (RefSeq) compare
b4397 creA +0.4 1.3 hypothetical protein (NCBI) compare
b2096 gatY +0.4 2.0 tagatose-bisphosphate aldolase 1 (VIMSS) compare
b2969 yghE +0.4 1.1 predicted secretion pathway protein, L-type protein (pseudogene) (RefSeq) compare
b1672 ydhW +0.4 1.8 hypothetical protein (NCBI) compare
b1379 hslJ +0.4 1.9 heat-inducible protein (NCBI) compare
b0238 gpt +0.4 1.6 xanthine phosphoribosyltransferase (NCBI) compare
b0928 aspC +0.4 1.7 aspartate aminotransferase, PLP-dependent (NCBI) compare
b4012 yjaB +0.4 1.2 predicted acetyltransferase (NCBI) compare
b1904 yecR +0.4 1.0 hypothetical protein (NCBI) compare
b1134 ymfB +0.4 1.0 bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase (NCBI) compare
b2531 iscR +0.4 0.6 DNA-binding transcriptional repressor (NCBI) compare
b2911 ssrS +0.4 0.6 6S regulatory RNA (NCBI) compare
b4596 yciZ +0.4 0.8 hypothetical protein (RefSeq) compare
b1273 yciN +0.4 0.9 hypothetical protein (NCBI) compare
b4041 plsB +0.4 1.0 glycerol-3-phosphate acyltransferase (VIMSS) compare
b2340 sixA +0.4 1.6 phosphohistidine phosphatase (NCBI) compare
b1528 ydeA +0.4 2.1 sugar efflux transporter (NCBI) compare
b1630 rsxD +0.4 1.9 electron transport complex protein RnfD (NCBI) compare
b0556 rzpD +0.4 1.2 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b0097 yacA +0.4 1.2 orf, hypothetical protein (VIMSS) compare
b2701 mltB +0.4 2.0 membrane-bound lytic murein transglycosylase B (NCBI) compare
b3146 yraL +0.4 2.0 predicted methyltransferase (NCBI) compare
b0970 yccA +0.4 1.4 inner membrane protein (NCBI) compare
b0570 cusS +0.4 2.4 sensory histidine kinase in two-component regulatory system with CusR, senses copper ions (NCBI) compare
b1569 dicC +0.4 1.5 Qin prophage; DNA-binding transcriptional regulator for DicB (NCBI) compare
b4450 arcZ +0.4 1.4 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b4017 arpA +0.4 1.1 regulator of acetyl CoA synthetase (NCBI) compare
b4578 insP +0.4 1.2 no description compare
b4532 yncN +0.4 1.3 orf, hypothetical protein (VIMSS) compare


Specific Phenotypes

For 4 genes in this experiment

For stress Norfloxacin in Escherichia coli BW25113

For stress Norfloxacin across organisms