Experiment set10IT070 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Ramoplanin 0.00003125 mM

200 most important genes:

  gene name fitness t score description  
b1334 fnr -4.1 -2.8 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b4220 ytfM -4.1 -15.3 predicted outer membrane protein and surface antigen (NCBI) compare
b2512 yfgL -4.0 -6.0 protein assembly complex, lipoprotein component (NCBI) compare
b4221 ytfN -3.9 -20.6 hypothetical protein (NCBI) compare
b0741 pal -3.1 -2.2 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b0740 tolB -3.1 -3.0 translocation protein TolB precursor (NCBI) compare
b0053 surA -2.9 -2.9 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1361 ydaW -2.8 -1.5 orf, hypothetical protein (VIMSS) compare
b3839 tatC -2.6 -6.4 TatABCE protein translocation system subunit (NCBI) compare
b0739 tolA -2.4 -1.7 cell envelope integrity inner membrane protein TolA (NCBI) compare
b3390 aroK -2.4 -2.3 shikimate kinase I (NCBI) compare
b3620 rfaF -2.3 -5.5 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b0949 uup -2.3 -8.9 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b4238 nrdD -2.2 -13.6 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b1855 lpxM -2.2 -5.9 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b2330 yfcB -2.2 -1.5 putative adenine-specific methylase (VIMSS) compare
b3619 rfaD -2.2 -3.0 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b4237 nrdG -2.1 -8.3 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b0903 pflB -2.1 -11.4 pyruvate formate lyase I (NCBI) compare
b3636 rpmG -2.1 -2.4 50S ribosomal protein L33 (NCBI) compare
b0239 frsA -2.1 -9.5 fermentation/respiration switch protein (NCBI) compare
b4529 ydbJ -2.1 -1.6 hypothetical protein (NCBI) compare
b1175 minD -2.1 -5.0 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b0902 pflA -2.1 -6.2 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b0990 cspG -2.0 -1.9 DNA-binding transcriptional regulator (NCBI) compare
b3792 wzxE -2.0 -6.6 O-antigen translocase (NCBI) compare
b0677 nagA -2.0 -5.8 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b0688 pgm -2.0 -3.4 phosphoglucomutase (NCBI) compare
b3052 rfaE -1.9 -5.0 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b2620 smpB -1.9 -1.8 SsrA-binding protein (NCBI) compare
b1865 nudB -1.9 -1.8 dATP pyrophosphohydrolase (NCBI) compare
b0738 tolR -1.9 -1.3 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3621 rfaC -1.9 -4.8 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b4520 ymgF -1.9 -1.7 hypothetical protein (NCBI) compare
b3199 yrbK -1.8 -3.0 hypothetical protein (NCBI) compare
b4702 mgtL -1.8 -2.1 regulatory leader peptide for mgtA (NCBI) compare
b3341 rpsG -1.8 -1.7 30S ribosomal protein S7 (NCBI) compare
b2313 cvpA -1.8 -4.8 membrane protein required for colicin V production (NCBI) compare
b2363 yfdT -1.8 -2.8 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b1882 cheY -1.8 -0.9 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b0737 tolQ -1.8 -2.0 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0149 mrcB -1.8 -11.0 penicillin-binding protein 1b (NCBI) compare
b2188 yejM -1.7 -8.7 predicted hydrolase, inner membrane (NCBI) compare
b3443 yrhA -1.7 -1.9 orf, hypothetical protein (VIMSS) compare
b3405 ompR -1.6 -4.5 osmolarity response regulator (NCBI) compare
b1874 cutC -1.6 -2.9 copper homeostasis protein (NCBI) compare
b1530 marR -1.6 -3.7 multiple antibiotic resistance protein; repressor of mar operon (VIMSS) compare
b0049 apaH -1.6 -2.7 diadenosinetetraphosphatase (NCBI) compare
b1600 mdtJ -1.6 -1.1 multidrug efflux system transporter (NCBI) compare
b2175 spr -1.6 -3.7 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b0222 lpcA -1.6 -2.7 phosphoheptose isomerase (NCBI) compare
b1358 ydaT -1.5 -1.4 Rac prophage; predicted protein (NCBI) compare
b3250 mreC -1.5 -2.2 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b2085 b2085 -1.5 -2.8 orf, hypothetical protein (VIMSS) compare
b0439 lon -1.5 -3.9 DNA-binding ATP-dependent protease La (NCBI) compare
b4025 pgi -1.5 -6.5 glucose-6-phosphate isomerase (NCBI) compare
b0730 mngR -1.5 -1.3 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b4535 yniD -1.5 -1.3 predicted protein (RefSeq) compare
b1476 fdnI -1.4 -1.3 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b2912 ygfA -1.4 -3.1 putative ligase (VIMSS) compare
b1726 yniB -1.4 -2.4 predicted inner membrane protein (NCBI) compare
b2859 ygeO -1.4 -1.6 hypothetical protein (RefSeq) compare
b3930 menA -1.4 -9.0 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b3838 tatB -1.4 -6.3 sec-independent translocase (NCBI) compare
b3609 secB -1.4 -3.2 export protein SecB (NCBI) compare
b3150 yraP -1.4 -5.6 hypothetical protein (NCBI) compare
b1984 asnW -1.4 -1.4 tRNA-Asn (NCBI) compare
b3229 sspA -1.4 -2.2 stringent starvation protein A (NCBI) compare
b1863 ruvC -1.4 -1.5 Holliday junction resolvase (NCBI) compare
b2051 wcaH -1.3 -1.7 GDP-mannose mannosyl hydrolase (VIMSS) compare
b0683 fur -1.3 -1.5 ferric uptake regulator (NCBI) compare
b0386 proC -1.3 -3.7 pyrroline-5-carboxylate reductase (NCBI) compare
b2369 evgA -1.3 -1.8 DNA-binding response regulator in two-component regulatory system with EvgS (NCBI) compare
b1677 lpp -1.3 -1.5 murein lipoprotein (NCBI) compare
b0783 moaC -1.3 -3.0 molybdenum cofactor biosynthesis protein C (NCBI) compare
b1493 gadB -1.3 -1.0 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b2181 yejG -1.3 -3.7 hypothetical protein (NCBI) compare
b4503 yafF -1.3 -0.8 no description compare
b1824 yobF -1.3 -2.9 hypothetical protein (NCBI) compare
b2617 smpA -1.3 -2.5 small membrane protein A (VIMSS) compare
b2567 rnc -1.3 -0.8 ribonuclease III (NCBI) compare
b2830 nudH -1.3 -1.2 dinucleoside polyphosphate hydrolase (NCBI) compare
b0009 mog -1.3 -6.1 molybdenum cofactor biosynthesis protein (NCBI) compare
b3164 pnp -1.2 -2.0 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2376 ypdI -1.2 -2.3 predicted lipoprotein involved in colanic acid biosynthesis (NCBI) compare
b4701 sokX -1.2 -1.1 sok-related sRNA, function unknown (RefSeq) compare
b4676 yoaK -1.2 -0.8 expressed protein (RefSeq) compare
b1049 mdoH -1.2 -6.3 glucosyltransferase MdoH (NCBI) compare
b1192 ldcA -1.2 -4.2 L,D-carboxypeptidase A (NCBI) compare
b1503 ydeR -1.2 -2.2 predicted fimbrial-like adhesin protein (NCBI) compare
b1236 galU -1.2 -3.1 glucose-1-phosphate uridylyltransferase (NCBI) compare
b4551 yheV -1.2 -2.4 hypothetical protein (NCBI) compare
b2528 iscA -1.2 -1.5 iron-sulfur cluster assembly protein (NCBI) compare
b1304 pspA -1.2 -3.1 regulatory protein for phage-shock-protein operon (NCBI) compare
b4568 ytjA -1.2 -2.0 predicted protein (RefSeq) compare
b1380 ldhA -1.2 -2.0 D-lactate dehydrogenase (NCBI) compare
b2894 xerD -1.2 -0.7 site-specific tyrosine recombinase XerD (NCBI) compare
b2935 tktA -1.2 -0.8 transketolase 1, thiamin-binding (NCBI) compare
b3631 rfaG -1.2 -7.8 glucosyltransferase I (NCBI) compare
b0232 yafN -1.2 -0.7 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b0765 modC -1.1 -3.8 molybdate transporter subunit (NCBI) compare
b1370 insH-5 -1.1 -2.1 Rac prophage; IS5 transposase and trans-activator (NCBI) compare
b0827 moeA -1.1 -4.2 molybdopterin biosynthesis protein (NCBI) compare
b0781 moaA -1.1 -5.5 molybdenum cofactor biosynthesis protein A (NCBI) compare
b2937 speB -1.1 -4.6 agmatinase (NCBI) compare
b3082 ygjM -1.1 -1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b4375 prfC -1.1 -1.8 peptide chain release factor 3 (NCBI) compare
b4505 insX -1.1 -1.6 predicted IS protein (RefSeq) compare
b1861 ruvA -1.1 -0.9 Holliday junction DNA helicase motor protein (NCBI) compare
b2820 recB -1.1 -0.7 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b1527 yneK -1.1 -1.4 hypothetical protein (NCBI) compare
b1048 mdoG -1.1 -3.7 glucan biosynthesis protein, periplasmic (NCBI) compare
b3613 yibP -1.1 -1.0 putative membrane protein (VIMSS) compare
b4541 yehK -1.0 -3.1 hypothetical protein (NCBI) compare
b3426 glpD -1.0 -2.8 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding (NCBI) compare
b2215 ompC -1.0 -5.4 outer membrane porin protein C (NCBI) compare
b1969 yedW -1.0 -2.7 putative 2-component transcriptional regulator (VIMSS) compare
b1951 rcsA -1.0 -0.7 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b2804 fucU -1.0 -2.1 L-fucose mutarotase (NCBI) compare
b2444 yffM -1.0 -1.9 CPZ-55 prophage; predicted protein (NCBI) compare
b4458 oxyS -1.0 -1.2 global regulatory RNA (NCBI) compare
b0728 sucC -1.0 -4.4 succinyl-CoA synthetase subunit beta (NCBI) compare
b4472 yhdP -1.0 -8.1 conserved membrane protein, predicted transporter (NCBI) compare
b3404 envZ -1.0 -6.0 osmolarity sensor protein (NCBI) compare
b3778 rep -1.0 -4.3 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b4239 treC -1.0 -1.1 trehalose-6-P hydrolase (NCBI) compare
b2064 asmA -1.0 -4.1 predicted assembly protein (NCBI) compare
b2252 ais -1.0 -2.6 hypothetical protein (NCBI) compare
b4191 ulaR -1.0 -2.3 DNA-binding transcriptional dual regulator (NCBI) compare
b0200 gmhB -0.9 -0.8 hypothetical protein (NCBI) compare
b3836 b3836 -0.9 -1.6 orf, hypothetical protein (VIMSS) compare
b0318 yahD -0.9 -3.8 predicted transcriptional regulator with ankyrin domain (NCBI) compare
b0826 moeB -0.9 -3.6 molybdopterin biosynthesis protein MoeB (NCBI) compare
b1291 sapD -0.9 -1.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2518 ndk -0.9 -1.6 nucleoside diphosphate kinase (NCBI) compare
b0499 ylbH -0.9 -2.4 conserved protein, rhs-like (RefSeq) compare
b3387 dam -0.9 -5.5 DNA adenine methylase (NCBI) compare
b4243 yjgF -0.9 -3.2 orf, hypothetical protein (VIMSS) compare
b2699 recA -0.9 -0.6 recombinase A (NCBI) compare
b2501 ppk -0.9 -5.1 polyphosphate kinase (NCBI) compare
b1850 eda -0.9 -1.6 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b1085 b1085 -0.9 -1.1 orf, hypothetical protein (VIMSS) compare
b0763 modA -0.9 -2.9 molybdate transporter subunit (NCBI) compare
b2111 yehD -0.9 -1.6 predicted fimbrial-like adhesin protein (NCBI) compare
b1648 b1648 -0.9 -1.3 orf, hypothetical protein (VIMSS) compare
b3916 pfkA -0.9 -1.4 6-phosphofructokinase (NCBI) compare
b1103 ycfF -0.9 -1.1 orf, hypothetical protein (VIMSS) compare
b1176 minC -0.8 -1.9 septum formation inhibitor (NCBI) compare
b1160 elbA -0.8 -0.5 hypothetical protein (NCBI) compare
b0764 modB -0.8 -2.8 molybdate ABC transporter permease protein (NCBI) compare
b1536 ydeI -0.8 -0.6 hypothetical protein (NCBI) compare
b1769 ydjE -0.8 -3.4 predicted transporter (NCBI) compare
b1860 ruvB -0.8 -0.5 Holliday junction DNA helicase B (NCBI) compare
b0460 hha -0.8 -2.5 modulator of gene expression, with H-NS (NCBI) compare
b2375 yfdX -0.8 -1.8 hypothetical protein (NCBI) compare
b1454 yncG -0.8 -1.4 predicted enzyme (NCBI) compare
b2071 yegJ -0.8 -1.0 hypothetical protein (NCBI) compare
b4509 ylcG -0.8 -1.7 DLP12 prophage; predicted protein (NCBI) compare
b3629 rfaS -0.8 -1.4 lipopolysaccharide core biosynthesis protein (NCBI) compare
b0729 sucD -0.8 -2.1 succinyl-CoA synthetase subunit alpha (NCBI) compare
b1241 adhE -0.8 -4.4 fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase (NCBI) compare
b3858 yihD -0.8 -1.7 hypothetical protein (NCBI) compare
b3871 bipA -0.8 -5.1 GTP-binding protein (NCBI) compare
b3726 pstA -0.8 -2.6 phosphate transporter subunit (NCBI) compare
b1269 rluB -0.8 -1.8 23S rRNA pseudouridylate synthase (NCBI) compare
b1187 fadR -0.8 -3.4 fatty acid metabolism regulator (NCBI) compare
b4202 rpsR -0.8 -0.7 30S ribosomal protein S18 (NCBI) compare
b1163 ycgF -0.8 -2.7 predicted FAD-binding phosphodiesterase (NCBI) compare
b0051 ksgA -0.8 -2.3 dimethyladenosine transferase (NCBI) compare
b0464 acrR -0.8 -5.8 DNA-binding transcriptional repressor (NCBI) compare
b1572 ydfB -0.8 -1.2 orf, hypothetical protein (VIMSS) compare
b1461 ydcE -0.8 -1.5 4-oxalocrotonate tautomerase (NCBI) compare
b2329 aroC -0.8 -3.1 chorismate synthase (NCBI) compare
b3741 gidA -0.8 -1.6 glucose-inhibited division protein A (NCBI) compare
b4642 yoeD -0.8 -2.0 no description compare
b2393 nupC -0.8 -3.3 nucleoside (except guanosine) transporter (NCBI) compare
b3616 tdh -0.8 -3.1 L-threonine 3-dehydrogenase (NCBI) compare
b3479 nikD -0.8 -4.4 nickel transporter subunit (NCBI) compare
b1644 b1644 -0.7 -2.3 putative membrane protein (VIMSS) compare
b3652 recG -0.7 -4.2 ATP-dependent DNA helicase (NCBI) compare
b3261 fis -0.7 -0.8 DNA-binding protein Fis (NCBI) compare
b0989 cspH -0.7 -0.9 stress protein, member of the CspA-family (NCBI) compare
b0141 yadN -0.7 -3.0 predicted fimbrial-like adhesin protein (NCBI) compare
b2165 yeiN -0.7 -2.9 hypothetical protein (NCBI) compare
b2569 lepA -0.7 -1.9 GTP-binding protein LepA (NCBI) compare
b4177 purA -0.7 -0.9 adenylosuccinate synthetase (NCBI) compare
b3857 mobA -0.7 -3.5 molybdopterin-guanine dinucleotide biosynthesis protein A (NCBI) compare
b1482 osmC -0.7 -1.3 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b0617 citD -0.7 -1.6 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b0218 yafU -0.7 -1.2 predicted inner membrane protein (RefSeq) compare
b3842 rfaH -0.7 -2.7 transcriptional activator RfaH (NCBI) compare
b3086 ygjQ -0.7 -2.7 predicted thioredoxin-like (NCBI) compare
b1579 intQ -0.7 -1.3 Qin prophage; predicted defective integrase (RefSeq) compare
b4481 rffT -0.7 -3.5 4-alpha-L-fucosyltransferase (NCBI) compare
b3408 feoA -0.7 -5.3 ferrous iron transport protein A (NCBI) compare
b1642 slyA -0.7 -1.0 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b2318 truA -0.7 -1.7 tRNA pseudouridine synthase A (NCBI) compare
b1573 ydfC -0.7 -1.0 Qin prophage; predicted protein (RefSeq) compare
b3630 rfaP -0.7 -4.0 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b1273 yciN -0.7 -1.2 hypothetical protein (NCBI) compare


Specific Phenotypes

For 2 genes in this experiment

For stress Ramoplanin in Escherichia coli BW25113

For stress Ramoplanin across organisms