Experiment set10IT064 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Vancomycin Hydrochloride from Streptomyces orientalis 0.00003125 mM

200 most important genes:

  gene name fitness t score description  
b1105 ycfM -6.1 -4.2 predicted outer membrane lipoprotein (NCBI) compare
b2313 cvpA -5.6 -3.9 membrane protein required for colicin V production (NCBI) compare
b1111 ycfQ -5.6 -3.8 orf, hypothetical protein (VIMSS) compare
b0436 tig -5.4 -3.7 trigger factor (NCBI) compare
b2617 smpA -5.3 -3.6 small membrane protein A (VIMSS) compare
b0178 hlpA -5.3 -3.6 periplasmic chaperone (NCBI) compare
b2188 yejM -5.2 -5.0 predicted hydrolase, inner membrane (NCBI) compare
b2571 rseB -5.1 -6.1 periplasmic negative regulator of sigmaE (NCBI) compare
b4472 yhdP -5.1 -15.7 conserved membrane protein, predicted transporter (NCBI) compare
b4221 ytfN -4.8 -18.5 hypothetical protein (NCBI) compare
b4053 alr -4.6 -8.2 alanine racemase (NCBI) compare
b0149 mrcB -4.5 -6.9 penicillin-binding protein 1b (NCBI) compare
b4220 ytfM -4.5 -14.0 predicted outer membrane protein and surface antigen (NCBI) compare
b3199 yrbK -4.4 -3.0 hypothetical protein (NCBI) compare
b3636 rpmG -4.3 -2.9 50S ribosomal protein L33 (NCBI) compare
b4238 nrdD -4.3 -17.7 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b3017 sufI -4.3 -13.1 repressor protein for FtsI (NCBI) compare
b0949 uup -4.3 -7.6 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b2512 yfgL -4.3 -4.1 protein assembly complex, lipoprotein component (NCBI) compare
b2215 ompC -4.2 -5.7 outer membrane porin protein C (NCBI) compare
b1192 ldcA -4.1 -5.6 L,D-carboxypeptidase A (NCBI) compare
b2937 speB -4.0 -2.8 agmatinase (NCBI) compare
b4237 nrdG -3.9 -10.7 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b1855 lpxM -3.9 -4.6 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b2494 yfgC -3.8 -8.0 predicted peptidase (NCBI) compare
b1175 minD -3.8 -4.4 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b2572 rseA -3.7 -7.1 anti-sigma factor (NCBI) compare
b0677 nagA -3.6 -3.5 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b2528 iscA -3.6 -2.4 iron-sulfur cluster assembly protein (NCBI) compare
b4025 pgi -3.5 -5.9 glucose-6-phosphate isomerase (NCBI) compare
b3963 fabR -3.5 -9.7 DNA-binding transcriptional repressor (RefSeq) compare
b2175 spr -3.5 -4.1 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b0729 sucD -3.4 -4.6 succinyl-CoA synthetase subunit alpha (NCBI) compare
b3838 tatB -3.3 -8.0 sec-independent translocase (NCBI) compare
b3387 dam -3.3 -9.2 DNA adenine methylase (NCBI) compare
b3405 ompR -3.3 -2.3 osmolarity response regulator (NCBI) compare
b3404 envZ -3.3 -9.9 osmolarity sensor protein (NCBI) compare
b3871 bipA -3.2 -11.1 GTP-binding protein (NCBI) compare
b1842 holE -3.2 -2.2 DNA polymerase III, theta subunit (NCBI) compare
b2435 amiA -3.2 -6.0 N-acetylmuramoyl-l-alanine amidase I (NCBI) compare
b3150 yraP -3.2 -7.8 hypothetical protein (NCBI) compare
b3792 wzxE -3.1 -3.7 O-antigen translocase (NCBI) compare
b3443 yrhA -3.1 -2.1 orf, hypothetical protein (VIMSS) compare
b3839 tatC -3.1 -3.0 TatABCE protein translocation system subunit (NCBI) compare
b4000 hupA -3.0 -5.1 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b3928 yiiU -3.0 -7.7 hypothetical protein (NCBI) compare
b0386 proC -3.0 -2.9 pyrroline-5-carboxylate reductase (NCBI) compare
b0239 frsA -3.0 -8.4 fermentation/respiration switch protein (NCBI) compare
b0145 dksA -3.0 -2.0 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b1126 potA -3.0 -6.5 putrescine/spermidine ABC transporter ATPase protein (NCBI) compare
b0740 tolB -2.9 -2.0 translocation protein TolB precursor (NCBI) compare
b0226 dinJ -2.9 -4.8 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b3778 rep -2.8 -3.9 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b4509 ylcG -2.8 -2.3 DLP12 prophage; predicted protein (NCBI) compare
b0741 pal -2.8 -1.9 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b0990 cspG -2.8 -1.9 DNA-binding transcriptional regulator (NCBI) compare
b1123 potD -2.8 -5.2 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b0623 cspE -2.7 -2.4 cold shock protein E (NCBI) compare
b0053 surA -2.7 -1.9 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1493 gadB -2.7 -1.2 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b3687 ibpA -2.7 -9.0 heat shock chaperone (NCBI) compare
b4201 priB -2.6 -3.1 primosomal replication protein N (NCBI) compare
b3740 gidB -2.6 -10.7 glucose-inhibited division protein B (NCBI) compare
b0014 dnaK -2.6 -1.8 molecular chaperone DnaK (NCBI) compare
b1124 potC -2.6 -5.4 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b2518 ndk -2.6 -1.8 nucleoside diphosphate kinase (NCBI) compare
b2477 nlpB -2.6 -4.9 lipoprotein-34 (VIMSS) compare
b1361 ydaW -2.6 -1.2 orf, hypothetical protein (VIMSS) compare
b2939 yqgB -2.5 -1.5 predicted protein (RefSeq) compare
b1249 cls -2.5 -6.7 cardiolipin synthetase (NCBI) compare
b3341 rpsG -2.5 -1.7 30S ribosomal protein S7 (NCBI) compare
b0082 mraW -2.5 -3.3 S-adenosyl-methyltransferase (NCBI) compare
b1850 eda -2.4 -2.8 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b3196 yrbG -2.4 -7.5 predicted calcium/sodium:proton antiporter (NCBI) compare
b3933 ftsN -2.4 -11.3 essential cell division protein (NCBI) compare
b1286 rnb -2.4 -1.6 exoribonuclease II (NCBI) compare
b3237 argR -2.4 -3.9 arginine repressor (NCBI) compare
b0957 ompA -2.4 -2.6 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b3409 feoB -2.3 -16.3 ferrous iron transport protein B (NCBI) compare
b3649 rpoZ -2.3 -3.5 DNA-directed RNA polymerase subunit omega (NCBI) compare
b3554 yiaF -2.3 -10.5 orf, hypothetical protein (VIMSS) compare
b1847 yebF -2.3 -2.2 predicted protein (RefSeq) compare
b3247 cafA -2.3 -7.5 bundles of cytoplasmic filaments (VIMSS) compare
b0902 pflA -2.3 -7.2 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b2576 srmB -2.3 -1.5 ATP-dependent RNA helicase (NCBI) compare
b3836 b3836 -2.2 -4.6 orf, hypothetical protein (VIMSS) compare
b1334 fnr -2.2 -2.6 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b2620 smpB -2.2 -1.5 SsrA-binding protein (NCBI) compare
b0737 tolQ -2.2 -1.5 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b4139 aspA -2.1 -8.9 aspartate ammonia-lyase (aspartase) (VIMSS) compare
b0440 hupB -2.1 -5.5 HU, DNA-binding transcriptional regulator, beta subunit (NCBI) compare
b1348 lar -2.1 -1.4 Rac prophage; restriction alleviation protein (NCBI) compare
b1125 potB -2.1 -4.6 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b2242 glpB -2.1 -7.3 anaerobic glycerol-3-phosphate dehydrogenase subunit B (NCBI) compare
b2243 glpC -2.1 -7.0 sn-glycerol-3-phosphate dehydrogenase (anaerobic), small subunit (NCBI) compare
b0814 ompX -2.1 -4.1 outer membrane protein X (NCBI) compare
b3198 kdsC -2.1 -2.3 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b2241 glpA -2.0 -10.8 sn-glycerol-3-phosphate dehydrogenase (anaerobic), large subunit, FAD/NAD(P)-binding (NCBI) compare
b2363 yfdT -2.0 -2.4 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b4451 ryhB -2.0 -1.9 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b3408 feoA -2.0 -10.0 ferrous iron transport protein A (NCBI) compare
b0868 b0868 -2.0 -9.4 putative nucleotide di-P-sugar epimerase or dehydratase (VIMSS) compare
b4701 sokX -2.0 -1.2 sok-related sRNA, function unknown (RefSeq) compare
b0434 yajG -2.0 -7.7 putative polymerase/proteinase (VIMSS) compare
b2784 relA -1.9 -9.1 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b0903 pflB -1.9 -10.3 pyruvate formate lyase I (NCBI) compare
b4535 yniD -1.9 -1.3 predicted protein (RefSeq) compare
b0764 modB -1.9 -3.9 molybdate ABC transporter permease protein (NCBI) compare
b1575 dicB -1.9 -1.8 Qin prophage; cell division inhibition protein (NCBI) compare
b0739 tolA -1.9 -1.8 cell envelope integrity inner membrane protein TolA (NCBI) compare
b2330 yfcB -1.9 -1.2 putative adenine-specific methylase (VIMSS) compare
b1724 ydiZ -1.8 -2.6 hypothetical protein (NCBI) compare
b2569 lepA -1.8 -2.4 GTP-binding protein LepA (NCBI) compare
b2910 zapA -1.8 -4.4 protein that localizes to the cytokinetic ring (NCBI) compare
b4529 ydbJ -1.8 -1.2 hypothetical protein (NCBI) compare
b0142 folK -1.8 -0.8 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b1878 flhE -1.8 -5.2 hypothetical protein (NCBI) compare
b0847 ybjL -1.8 -8.2 hypothetical protein (NCBI) compare
b0018 mokC -1.8 -1.4 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b2553 glnB -1.8 -4.6 regulatory protein P-II for glutamine synthetase (NCBI) compare
b4655 ythA -1.8 -1.7 expressed protein (RefSeq) compare
b2506 yfgI -1.8 -2.6 hypothetical protein (NCBI) compare
b2689 yqaA -1.8 -4.3 conserved inner membrane protein (NCBI) compare
b0728 sucC -1.7 -4.7 succinyl-CoA synthetase subunit beta (NCBI) compare
b1176 minC -1.7 -2.8 septum formation inhibitor (NCBI) compare
b4234 yjgA -1.7 -4.6 hypothetical protein (NCBI) compare
b2646 ypjF -1.7 -1.5 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b1164 ycgZ -1.7 -1.6 hypothetical protein (NCBI) compare
b2498 upp -1.7 -2.2 uracil phosphoribosyltransferase (VIMSS) compare
b2064 asmA -1.6 -2.4 predicted assembly protein (NCBI) compare
b1150 ymfR -1.6 -1.1 e14 prophage; predicted protein (NCBI) compare
b4614 sokA -1.6 -2.8 no description compare
b4402 yjjY -1.6 -1.0 hypothetical protein (NCBI) compare
b2501 ppk -1.6 -6.8 polyphosphate kinase (NCBI) compare
b3197 kdsD -1.6 -5.7 D-arabinose 5-phosphate isomerase (NCBI) compare
b1530 marR -1.6 -4.1 multiple antibiotic resistance protein; repressor of mar operon (VIMSS) compare
b0548 ninE -1.6 -2.1 DLP12 prophage; conserved protein (NCBI) compare
b0785 moaE -1.6 -4.9 molybdopterin synthase, large subunit (NCBI) compare
b0049 apaH -1.6 -2.3 diadenosinetetraphosphatase (NCBI) compare
b2830 nudH -1.6 -1.0 dinucleoside polyphosphate hydrolase (NCBI) compare
b2896 ygfX -1.6 -3.1 hypothetical protein (NCBI) compare
b0929 ompF -1.6 -3.5 outer membrane porin 1a (Ia;b;F) (NCBI) compare
b3166 truB -1.5 -6.4 tRNA pseudouridine synthase B (NCBI) compare
b1503 ydeR -1.5 -1.5 predicted fimbrial-like adhesin protein (NCBI) compare
b4191 ulaR -1.5 -3.5 DNA-binding transcriptional dual regulator (NCBI) compare
b1108 ycfP -1.5 -2.1 orf, hypothetical protein (VIMSS) compare
b3388 damX -1.5 -9.7 hypothetical protein (NCBI) compare
b2808 gcvA -1.5 -2.6 DNA-binding transcriptional dual regulator (NCBI) compare
b2433 b2433 -1.5 -2.4 orf, hypothetical protein (VIMSS) compare
b3469 zntA -1.5 -5.2 zinc, cobalt and lead efflux system (NCBI) compare
b0730 mngR -1.5 -1.4 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b1920 fliY -1.5 -2.0 cystine transporter subunit (NCBI) compare
b1252 tonB -1.4 -2.8 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b3183 obgE -1.4 -0.9 GTPase involved in cell partioning and DNA repair (NCBI) compare
b0939 ycbR -1.4 -6.1 predicted periplasmic pilin chaperone (NCBI) compare
b2168 fruK -1.4 -1.2 1-phosphofructokinase (NCBI) compare
b2513 yfgM -1.4 -5.2 hypothetical protein (NCBI) compare
b3930 menA -1.4 -9.5 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b2938 speA -1.4 -6.7 arginine decarboxylase (NCBI) compare
b4702 mgtL -1.4 -1.6 regulatory leader peptide for mgtA (NCBI) compare
b2141 yohJ -1.4 -2.4 hypothetical protein (NCBI) compare
b1739 osmE -1.4 -1.5 DNA-binding transcriptional activator (NCBI) compare
b3226 yhcK -1.4 -4.0 putative FADA-type transcriptional regulator (VIMSS) compare
b3617 kbl -1.4 -5.5 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare
b4049 dusA -1.4 -5.2 tRNA-dihydrouridine synthase A (RefSeq) compare
b1823 cspC -1.4 -1.8 stress protein, member of the CspA-family (NCBI) compare
b3416 malQ -1.4 -8.0 4-alpha-glucanotransferase (amylomaltase) (NCBI) compare
b2809 b2809 -1.4 -1.4 orf, hypothetical protein (VIMSS) compare
b1278 pgpB -1.4 -1.3 phosphatidylglycerophosphatase B (NCBI) compare
b3096 yqjB -1.4 -3.4 hypothetical protein (NCBI) compare
b3238 yhcN -1.4 -1.4 orf, hypothetical protein (VIMSS) compare
b3082 ygjM -1.4 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b2517 yfgB -1.3 -5.5 predicted enzyme (NCBI) compare
b0218 yafU -1.3 -1.6 predicted inner membrane protein (RefSeq) compare
b1594 dgsA -1.3 -2.8 DNA-binding transcriptional repressor (NCBI) compare
b1566 flxA -1.3 -2.8 Qin prophage; predicted protein (NCBI) compare
b0441 ppiD -1.3 -7.4 peptidyl-prolyl cis-trans isomerase (rotamase D) (NCBI) compare
b1567 intK -1.3 -2.0 Qin prophage; predicted protein (RefSeq) compare
b3529 yhjK -1.3 -8.9 predicted diguanylate cyclase (RefSeq) compare
b1370 insH-5 -1.3 -2.1 Rac prophage; IS5 transposase and trans-activator (NCBI) compare
b2259 pmrD -1.3 -0.8 polymyxin resistance protein B (VIMSS) compare
b3803 hemX -1.3 -6.6 predicted uroporphyrinogen III methylase (NCBI) compare
b0438 clpX -1.3 -4.7 ATP-dependent protease ATP-binding subunit (NCBI) compare
b0547 ybcN -1.3 -2.0 DLP12 prophage; predicted protein (NCBI) compare
b0738 tolR -1.3 -1.2 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3229 sspA -1.3 -1.9 stringent starvation protein A (NCBI) compare
b0888 trxB -1.3 -2.1 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b3609 secB -1.3 -2.1 export protein SecB (NCBI) compare
b2457 cchA -1.3 -3.3 detox protein (VIMSS) compare
b3391 hofQ -1.3 -6.0 predicted fimbrial transporter (NCBI) compare
b0826 moeB -1.3 -4.5 molybdopterin biosynthesis protein MoeB (NCBI) compare
b1969 yedW -1.3 -1.9 putative 2-component transcriptional regulator (VIMSS) compare
b4179 vacB -1.2 -3.3 putative enzyme (VIMSS) compare
b3500 gor -1.2 -1.2 glutathione reductase (NCBI) compare
b1607 ydgC -1.2 -1.4 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b1831 proQ -1.2 -2.1 putative solute/DNA competence effector (NCBI) compare
b1598 ydgD -1.2 -3.2 predicted peptidase (NCBI) compare
b0763 modA -1.2 -3.3 molybdate transporter subunit (NCBI) compare
b1804 rnd -1.2 -3.1 ribonuclease D (NCBI) compare
b4699 fnrS -1.2 -0.8 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare


Specific Phenotypes

For 47 genes in this experiment

For stress Vancomycin Hydrochloride from Streptomyces orientalis in Escherichia coli BW25113

For stress Vancomycin Hydrochloride from Streptomyces orientalis across organisms