Experiment set10IT062 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Sulfamonomethoxine 0.00003125 mM

200 most detrimental genes:

  gene name fitness t score description  
b2289 lrhA +2.5 18.5 DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes (NCBI) compare
b2259 pmrD +2.1 2.8 polymyxin resistance protein B (VIMSS) compare
b1429 tehA +1.9 2.1 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b2684 mprA +1.7 7.6 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b4480 hdfR +1.3 6.5 transcriptional regulator HdfR (NCBI) compare
b3764 yifE +1.2 4.9 hypothetical protein (NCBI) compare
b4416 rybA +1.0 1.9 unknown RNA (NCBI) compare
b1217 chaB +0.9 1.4 cation transport regulator (NCBI) compare
b2531 iscR +0.9 1.7 DNA-binding transcriptional repressor (NCBI) compare
b2114 metG +0.9 2.4 methionyl-tRNA synthetase (NCBI) compare
b1618 uidR +0.9 3.4 DNA-binding transcriptional repressor (NCBI) compare
b4585 sroB +0.9 1.4 Novel sRNA, function unknown (RefSeq) compare
b2093 gatB +0.9 3.8 galactitol-specific enzyme IIB component of PTS (NCBI) compare
b2096 gatY +0.9 3.9 tagatose-bisphosphate aldolase 1 (VIMSS) compare
b2061 wzb +0.8 1.9 protein-tyrosine phosphatase (NCBI) compare
b1642 slyA +0.8 1.2 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b1684 sufA +0.8 2.0 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b1827 kdgR +0.8 1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b0641 rlpB +0.8 2.2 minor lipoprotein (NCBI) compare
b1231 tyrT +0.8 0.9 tRNA-Tyr (NCBI) compare
b4394 yjjX +0.8 2.6 orf, hypothetical protein (VIMSS) compare
b1651 gloA +0.8 2.2 glyoxalase I, Ni-dependent (NCBI) compare
b2145 yeiS +0.8 3.2 predicted inner membrane protein (NCBI) compare
b1806 yeaY +0.8 2.4 predicted lipoprotein (NCBI) compare
b1606 folM +0.8 5.0 short chain dehydrogenase (NCBI) compare
b1296 ycjJ +0.8 3.3 putative amino acid/amine transport protein (VIMSS) compare
b4041 plsB +0.8 1.9 glycerol-3-phosphate acyltransferase (VIMSS) compare
b4533 ynfO +0.8 1.4 Qin prophage; predicted protein (NCBI) compare
b2518 ndk +0.8 1.7 nucleoside diphosphate kinase (NCBI) compare
b0881 clpS +0.7 0.9 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b1607 ydgC +0.7 1.3 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b3658 selC +0.7 1.9 tRNA-Sec (NCBI) compare
b1279 yciS +0.7 0.9 conserved inner membrane protein (NCBI) compare
b1171 b1171 +0.7 1.9 orf, hypothetical protein (VIMSS) compare
b1573 ydfC +0.7 1.4 Qin prophage; predicted protein (RefSeq) compare
b0843 ybjH +0.7 1.8 hypothetical protein (NCBI) compare
b4369 leuP +0.7 1.8 tRNA-Leu (NCBI) compare
b2807 ygdD +0.7 2.2 conserved inner membrane protein (NCBI) compare
b1289 ycjD +0.7 2.2 hypothetical protein (NCBI) compare
b1394 paaG +0.7 1.4 enoyl-CoA hydratase (NCBI) compare
b1301 puuB +0.6 2.9 gamma-Glu-putrescine oxidase, FAD/NAD(P)-binding (NCBI) compare
b2217 rcsB +0.6 3.5 DNA-binding response regulator in two-component regulatory system with RcsC and YojN (NCBI) compare
b2303 folX +0.6 4.1 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase (NCBI) compare
b0580 ybdJ +0.6 1.9 predicted inner membrane protein (NCBI) compare
b1846 yebE +0.6 2.0 hypothetical protein (NCBI) compare
b4157 yjeN +0.6 2.6 hypothetical protein (NCBI) compare
b1007 b1007 +0.6 1.2 orf, hypothetical protein (VIMSS) compare
b4595 yciY +0.6 1.5 hypothetical protein (RefSeq) compare
b1867 yecD +0.6 3.1 orf, hypothetical protein (VIMSS) compare
b3752 rbsK +0.6 4.5 ribokinase (NCBI) compare
b4543 ypaA +0.6 2.3 predicted protein (NCBI) compare
b4699 fnrS +0.6 0.6 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b1359 ydaU +0.6 1.9 Rac prophage; conserved protein (NCBI) compare
b0579 ybdF +0.6 1.2 hypothetical protein (NCBI) compare
b0682 ybfN +0.6 2.1 predicted lipoprotein (NCBI) compare
b1954 dsrA +0.6 1.8 regulatory antisense RNA (NCBI) compare
b4589 ylcI +0.6 1.6 hypothetical protein (RefSeq) compare
b1242 ychE +0.6 2.2 predicted inner membrane protein (NCBI) compare
b4450 arcZ +0.6 2.0 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b2426 ucpA +0.6 1.0 putative oxidoreductase (VIMSS) compare
b3890 yiiF +0.6 1.4 orf, hypothetical protein (VIMSS) compare
b2006 yeeW +0.6 2.1 CP4-44 prophage; predicted protein (RefSeq) compare
b2281 nuoI +0.6 1.7 NADH dehydrogenase subunit I (NCBI) compare
b3769 ilvM +0.6 2.1 acetolactate synthase II, small subunit (NCBI) compare
b1343 dbpA +0.6 2.7 ATP-dependent RNA helicase, specific for 23S rRNA (NCBI) compare
b0885 aat +0.6 2.8 leucyl/phenylalanyl-tRNA--protein transferase (NCBI) compare
b4582 yoeA +0.6 2.4 no description compare
b1835 yebU +0.6 1.8 putative nucleolar proteins (VIMSS) compare
b2809 b2809 +0.6 1.8 orf, hypothetical protein (VIMSS) compare
b1920 fliY +0.6 1.0 cystine transporter subunit (NCBI) compare
b1415 aldA +0.6 2.3 Lactaldehyde / glycolaldehyde dehydrogenase aldA (EC 1.2.1.22; EC 1.2.1.21) (from data) compare
b3082 ygjM +0.6 1.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b0487 cueR +0.6 2.5 DNA-binding transcriptional activator of copper-responsive regulon genes (NCBI) compare
b2439 eutL +0.6 2.9 predicted carboxysome structural protein with predicted role in ethanolamine utilization (NCBI) compare
b1478 adhP +0.6 2.3 alcohol dehydrogenase (VIMSS) compare
b2195 ccmG +0.6 1.2 periplasmic thioredoxin of cytochrome c-type biogenesis (NCBI) compare
b1362 rzpR +0.6 1.4 putative Rac prophage endopeptidase (VIMSS) compare
b0200 gmhB +0.6 0.7 hypothetical protein (NCBI) compare
b1621 malX +0.6 2.3 fused maltose and glucose-specific PTS enzymes: IIB component -! IIC component (NCBI) compare
b4363 yjjB +0.6 1.6 conserved inner membrane protein (RefSeq) compare
b3071 yqjI +0.6 2.1 predicted transcriptional regulator (NCBI) compare
b3753 rbsR +0.5 3.7 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b2279 nuoK +0.5 1.0 NADH dehydrogenase subunit K (NCBI) compare
b0947 ycbX +0.5 2.8 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b0946 ycbW +0.5 2.3 orf, hypothetical protein (VIMSS) compare
b1251 yciI +0.5 1.9 orf, hypothetical protein (VIMSS) compare
b4653 yicT +0.5 1.3 no description compare
b1103 ycfF +0.5 0.8 orf, hypothetical protein (VIMSS) compare
b1281 pyrF +0.5 1.2 orotidine 5'-phosphate decarboxylase (NCBI) compare
b1348 lar +0.5 1.1 Rac prophage; restriction alleviation protein (NCBI) compare
b1751 ydjY +0.5 2.0 orf, hypothetical protein (VIMSS) compare
b2614 grpE +0.5 1.0 heat shock protein (NCBI) compare
b0388 aroL +0.5 1.9 shikimate kinase II (NCBI) compare
b0838 yliJ +0.5 2.5 putative transferase (VIMSS) compare
b4627 ykfL +0.5 2.1 no description compare
b4578 insP +0.5 1.5 no description compare
b0495 ybbA +0.5 2.2 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b2058 wcaB +0.5 0.6 predicted acyl transferase (NCBI) compare
b3129 sohA +0.5 2.2 predicted regulator (NCBI) compare
b0247 ykfG +0.5 0.8 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b2447 yffP +0.5 1.5 CPZ-55 prophage; predicted protein (NCBI) compare
b2506 yfgI +0.5 1.3 hypothetical protein (NCBI) compare
b2916 argP +0.5 2.7 chromosome replication initiation inhibitor protein (NCBI) compare
b1366 ydaY +0.5 1.8 Rac prophage; predicted protein (RefSeq) compare
b3096 yqjB +0.5 2.2 hypothetical protein (NCBI) compare
b2906 visC +0.5 2.4 hypothetical protein (NCBI) compare
b3361 fic +0.5 1.9 stationary-phase protein, cell division (NCBI) compare
b1577 ydfE +0.5 2.6 Qin prophage; predicted protein (RefSeq) compare
b3119 tdcR +0.5 1.3 threonine dehydratase operon activator protein (VIMSS) compare
b1273 yciN +0.5 1.0 hypothetical protein (NCBI) compare
b1101 ptsG +0.5 3.4 fused glucose-specific PTS enzymes: IIB component/IIC component (NCBI) compare
b0334 prpD +0.5 2.5 2-methylcitrate dehydratase (NCBI) compare
b1956 b1956 +0.5 2.2 orf, hypothetical protein (VIMSS) compare
b4685 yrbN +0.5 1.2 expressed protein (RefSeq) compare
b1524 yneH +0.5 0.4 predicted glutaminase (NCBI) compare
b0412 yajI +0.5 1.9 orf, hypothetical protein (VIMSS) compare
b2689 yqaA +0.5 1.3 conserved inner membrane protein (NCBI) compare
b1548 nohA +0.5 0.7 Qin prophage; predicted packaging protein (RefSeq) compare
b1728 ydjM +0.5 1.4 predicted inner membrane protein regulated by LexA (RefSeq) compare
b3149 yraO +0.5 2.3 DnaA initiator-associating factor for replication initiation (NCBI) compare
b2646 ypjF +0.5 1.3 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b0777 bioC +0.5 2.6 predicted methltransferase, enzyme of biotin synthesis (NCBI) compare
b2448 yffQ +0.5 1.3 CPZ-55 prophage; predicted protein (RefSeq) compare
b0866 ybjQ +0.5 0.7 hypothetical protein (NCBI) compare
b1487 ddpA +0.5 1.5 D-ala-D-a la transporter subunit (NCBI) compare
b0801 ybiC +0.5 2.6 predicted dehydrogenase (NCBI) compare
b1749 xthA +0.5 2.1 exonuclease III (NCBI) compare
b1434 ydcN +0.5 0.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b1622 malY +0.5 1.8 bifunctional beta-cystathionase, PLP-dependent/ regulator of maltose regulon (NCBI) compare
b3107 yhaL +0.5 0.8 orf, hypothetical protein (VIMSS) compare
b2187 yejL +0.5 1.0 hypothetical protein (NCBI) compare
b1763 topB +0.4 1.1 DNA topoisomerase III (NCBI) compare
b2635 ypjK +0.4 1.3 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b2934 cmtB +0.4 0.4 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b1438 ydcQ +0.4 1.6 predicted DNA-binding transcriptional regulator (RefSeq) compare
b2349 intS +0.4 2.1 CPS-53 (KpLE1) prophage; predicted prophage CPS-53 integrase (NCBI) compare
b2282 nuoH +0.4 1.5 NADH dehydrogenase subunit H (NCBI) compare
b1312 ycjP +0.4 2.6 predicted sugar transporter subunit: membrane component of ABC superfamily (NCBI) compare
b3455 livG +0.4 2.1 leucine/isoleucine/valine transporter subunit (NCBI) compare
b4490 efeU +0.4 2.7 no description compare
b0357 yaiN +0.4 0.8 putative alpha helix chain (VIMSS) compare
b2811 ygdK +0.4 1.3 predicted Fe-S metabolism protein (NCBI) compare
b2193 narP +0.4 1.9 DNA-binding response regulator in two-component regulatory system with NarQ or NarX (NCBI) compare
b1640 ydhH +0.4 1.2 anhydro-N-acetylmuramic acid kinase (NCBI) compare
b0365 tauA +0.4 1.9 taurine transport system periplasmic protein (VIMSS) compare
b2989 b2989 +0.4 2.1 orf, hypothetical protein (VIMSS) compare
b1765 ydjA +0.4 0.5 predicted oxidoreductase (NCBI) compare
b4301 sgcE +0.4 1.9 ribulose-phosphate 3-epimerase (NCBI) compare
b1742 b1742 +0.4 1.2 orf, hypothetical protein (VIMSS) compare
b1537 ydeJ +0.4 1.9 competence damage-inducible protein A (NCBI) compare
b1698 ydiR +0.4 1.3 predicted electron transfer flavoprotein, FAD-binding (NCBI) compare
b0109 nadC +0.4 2.0 nicotinate-nucleotide pyrophosphorylase (NCBI) compare
b1913 uvrC +0.4 2.4 excinuclease ABC, subunit C; repair of UV damage to DNA (VIMSS) compare
b4225 chpB +0.4 1.9 toxin of the ChpB-ChpS toxin-antitoxin system (NCBI) compare
b1233 ychJ +0.4 1.6 hypothetical protein (NCBI) compare
b4571 wbbL +0.4 1.2 no description compare
b2582 trxC +0.4 1.2 thioredoxin 2 (NCBI) compare
b0925 ycbB +0.4 2.5 predicted carboxypeptidase (NCBI) compare
b0428 cyoE +0.4 2.2 protoheme IX farnesyltransferase (NCBI) compare
b1379 hslJ +0.4 1.8 heat-inducible protein (NCBI) compare
b1729 ydjN +0.4 1.5 predicted transporter (NCBI) compare
b1904 yecR +0.4 1.2 hypothetical protein (NCBI) compare
b2209 eco +0.4 0.6 ecotin precursor (NCBI) compare
b2298 yfcC +0.4 2.3 putative S-transferase (VIMSS) compare
b1812 pabB +0.4 2.0 para-aminobenzoate synthase component I (NCBI) compare
b2136 yohD +0.4 0.8 orf, hypothetical protein (VIMSS) compare
b2674 nrdI +0.4 1.7 hypothetical protein (NCBI) compare
b1504 ydeS +0.4 1.8 predicted fimbrial-like adhesin protein (NCBI) compare
b4360 yjjA +0.4 1.2 putative glycoprotein/receptor (VIMSS) compare
b1380 ldhA +0.4 0.9 D-lactate dehydrogenase (NCBI) compare
b1743 spy +0.4 2.3 envelope stress induced periplasmic protein (NCBI) compare
b0818 ybiR +0.4 2.3 predicted transporter (NCBI) compare
b2446 yffO +0.4 1.1 CPZ-55 prophage; predicted protein (NCBI) compare
b2156 lysP +0.4 2.8 lysine transporter (NCBI) compare
b2019 hisG +0.4 2.2 ATP phosphoribosyltransferase (NCBI) compare
b1306 pspC +0.4 1.4 DNA-binding transcriptional activator (NCBI) compare
b0065 yabI +0.4 1.7 conserved inner membrane protein (NCBI) compare
b4484 cpxP +0.4 1.6 periplasmic protein combats stress (NCBI) compare
b4565 sgcB +0.4 1.5 predicted enzyme IIB component of PTS (NCBI) compare
b0505 allA +0.4 1.4 ureidoglycolate hydrolase (NCBI) compare
b1200 b1200 +0.4 1.8 putative dihydroxyacetone kinase (EC 2.7.1.2) (VIMSS) compare
b4598 yncL +0.4 0.9 hypothetical protein (RefSeq) compare
b0967 yccW +0.4 1.9 predicted methyltransferase (RefSeq) compare
b3141 agaI +0.4 1.9 galactosamine-6-phosphate isomerase (NCBI) compare
b0870 ltaE +0.4 1.3 L-allo-threonine aldolase, PLP-dependent (NCBI) compare
b1661 cfa +0.4 1.3 cyclopropane fatty acyl phospholipid synthase (unsaturated-phospholipid methyltransferase) (NCBI) compare
b1916 sdiA +0.4 2.6 DNA-binding transcriptional activator (NCBI) compare
b2082 ogrK +0.4 1.4 DNA-binding transcriptional regulator prophage P2 remnant (NCBI) compare
b3404 envZ +0.4 2.5 osmolarity sensor protein (NCBI) compare
b3057 bacA +0.4 2.0 undecaprenyl pyrophosphate phosphatase (NCBI) compare
b1793 yoaF +0.4 1.2 conserved outer membrane protein (NCBI) compare
b1414 ydcF +0.4 1.8 hypothetical protein (NCBI) compare
b0252 yafZ +0.4 1.4 orf, hypothetical protein (VIMSS) compare
b0187 yaeR +0.4 1.3 orf, hypothetical protein (VIMSS) compare
b3033 yqiB +0.4 2.0 predicted dehydrogenase (NCBI) compare
b2023 hisH +0.4 1.7 imidazole glycerol phosphate synthase subunit HisH (NCBI) compare
b2741 rpoS +0.4 1.6 RNA polymerase sigma factor (NCBI) compare
b1264 trpE +0.4 2.1 anthranilate synthase component I (NCBI) compare
b1120 cobB +0.4 1.2 deacetylase of acs and cheY, regulates chemotaxis (NCBI) compare
b0387 yaiI +0.4 1.7 orf, hypothetical protein (VIMSS) compare


Specific Phenotypes

For 2 genes in this experiment

For stress Sulfamonomethoxine in Escherichia coli BW25113

For stress Sulfamonomethoxine across organisms