Experiment set10IT059 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Nalidixic acid sodium salt 0.0000078125 mM

200 most important genes:

  gene name fitness t score description  
b3035 tolC -3.9 -7.0 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b4201 priB -3.5 -3.4 primosomal replication protein N (NCBI) compare
b3935 priA -2.9 -3.5 primosome assembly protein PriA (NCBI) compare
b1493 gadB -2.9 -1.5 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b1830 prc -2.8 -4.2 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b2617 smpA -2.8 -4.1 small membrane protein A (VIMSS) compare
b0053 surA -2.7 -3.7 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b3842 rfaH -2.7 -6.7 transcriptional activator RfaH (NCBI) compare
b1361 ydaW -2.7 -1.4 orf, hypothetical protein (VIMSS) compare
b0222 lpcA -2.6 -3.0 phosphoheptose isomerase (NCBI) compare
b3792 wzxE -2.6 -6.8 O-antigen translocase (NCBI) compare
b0178 hlpA -2.6 -5.1 periplasmic chaperone (NCBI) compare
b2512 yfgL -2.4 -6.4 protein assembly complex, lipoprotein component (NCBI) compare
b2642 yfjW -2.4 -1.6 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b3621 rfaC -2.4 -4.5 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b3052 rfaE -2.3 -6.1 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b0957 ompA -2.3 -4.1 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b3620 rfaF -2.3 -5.9 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b2571 rseB -2.3 -7.8 periplasmic negative regulator of sigmaE (NCBI) compare
b0463 acrA -2.3 -10.9 multidrug efflux system (NCBI) compare
b0049 apaH -2.2 -2.5 diadenosinetetraphosphatase (NCBI) compare
b3163 nlpI -2.2 -4.7 hypothetical protein (NCBI) compare
b4535 yniD -2.1 -1.4 predicted protein (RefSeq) compare
b3619 rfaD -2.1 -3.2 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b0462 acrB -2.1 -13.3 multidrug efflux system protein (NCBI) compare
b0623 cspE -2.0 -1.7 cold shock protein E (NCBI) compare
b2285 nuoE -2.0 -2.6 NADH dehydrogenase subunit E (NCBI) compare
b1831 proQ -1.9 -3.7 putative solute/DNA competence effector (NCBI) compare
b2509 xseA -1.9 -7.6 exodeoxyribonuclease VII large subunit (NCBI) conserved
b0014 dnaK -1.9 -2.0 molecular chaperone DnaK (NCBI) compare
b1334 fnr -1.9 -2.7 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b1848 yebG -1.8 -1.9 conserved protein regulated by LexA (NCBI) compare
b2620 smpB -1.8 -1.7 SsrA-binding protein (NCBI) compare
b2830 nudH -1.8 -1.2 dinucleoside polyphosphate hydrolase (NCBI) compare
b0990 cspG -1.8 -1.6 DNA-binding transcriptional regulator (NCBI) compare
b2616 recN -1.8 -8.5 recombination and repair protein (NCBI) conserved
b0149 mrcB -1.7 -10.6 penicillin-binding protein 1b (NCBI) compare
b1236 galU -1.7 -3.5 glucose-1-phosphate uridylyltransferase (NCBI) compare
b4702 mgtL -1.7 -1.9 regulatory leader peptide for mgtA (NCBI) compare
b3609 secB -1.7 -3.2 export protein SecB (NCBI) compare
b3631 rfaG -1.7 -10.5 glucosyltransferase I (NCBI) compare
b3630 rfaP -1.6 -7.4 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b1176 minC -1.6 -2.7 septum formation inhibitor (NCBI) compare
b4655 ythA -1.5 -1.7 expressed protein (RefSeq) compare
b2346 vacJ -1.5 -5.5 predicted lipoprotein (NCBI) compare
b1278 pgpB -1.5 -2.7 phosphatidylglycerophosphatase B (NCBI) compare
b4237 nrdG -1.5 -8.5 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b2892 recJ -1.4 -6.9 ssDNA exonuclease, 5' --> 3'-specific (NCBI) compare
b0630 lipB -1.4 -1.3 protein of lipoate biosynthesis (VIMSS) compare
b3784 rfe -1.3 -9.8 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b3195 yrbF -1.3 -8.4 predicted toluene transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b3082 ygjM -1.3 -1.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b3199 yrbK -1.3 -2.5 hypothetical protein (NCBI) compare
b3632 rfaQ -1.3 -10.4 lipopolysaccharide core biosynthesis protein (NCBI) compare
b0145 dksA -1.3 -2.8 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b2904 gcvH -1.3 -2.4 glycine cleavage system protein H (NCBI) compare
b3021 ygiT -1.2 -2.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b0730 mngR -1.2 -1.1 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b4238 nrdD -1.2 -9.5 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b4701 sokX -1.2 -1.1 sok-related sRNA, function unknown (RefSeq) compare
b3194 yrbE -1.2 -7.0 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b4503 yafF -1.2 -0.8 no description compare
b2572 rseA -1.2 -4.4 anti-sigma factor (NCBI) compare
b0740 tolB -1.2 -3.2 translocation protein TolB precursor (NCBI) compare
b3261 fis -1.2 -0.8 DNA-binding protein Fis (NCBI) compare
b1252 tonB -1.1 -2.5 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b1348 lar -1.1 -1.6 Rac prophage; restriction alleviation protein (NCBI) compare
b4613 dinQ -1.1 -1.9 Damage inducible, function unknown (RefSeq) compare
b2317 dedA -1.1 -3.4 conserved inner membrane protein (NCBI) compare
b4436 ryeC -1.1 -1.6 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b0738 tolR -1.1 -1.5 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0934 ycbM -1.1 -2.2 putative transport system permease protein (VIMSS) compare
b4676 yoaK -1.1 -0.7 expressed protein (RefSeq) compare
b2567 rnc -1.1 -0.7 ribonuclease III (NCBI) compare
b0549 ybcO -1.1 -2.1 DLP12 prophage; predicted protein (NCBI) compare
b0739 tolA -1.1 -1.9 cell envelope integrity inner membrane protein TolA (NCBI) compare
b4522 yciX_1 -1.1 -2.0 hypothetical protein (NCBI) compare
b2252 ais -1.1 -2.5 hypothetical protein (NCBI) compare
b3728 pstS -1.1 -1.2 phosphate transporter subunit (NCBI) compare
b1600 mdtJ -1.0 -1.3 multidrug efflux system transporter (NCBI) compare
b1105 ycfM -1.0 -2.8 predicted outer membrane lipoprotein (NCBI) compare
b1728 ydjM -1.0 -2.2 predicted inner membrane protein regulated by LexA (RefSeq) compare
b3870 glnA -1.0 -2.1 glutamine synthetase (NCBI) compare
b4441 glmY -1.0 -1.5 sRNA activator of glmS mRNA (RefSeq) compare
b3787 rffD -1.0 -6.3 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b2820 recB -1.0 -0.7 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b3627 rfaI -1.0 -5.3 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b1476 fdnI -1.0 -1.0 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b1847 yebF -1.0 -1.5 predicted protein (RefSeq) compare
b1085 b1085 -1.0 -1.6 orf, hypothetical protein (VIMSS) compare
b1863 ruvC -1.0 -1.1 Holliday junction resolvase (NCBI) compare
b3193 yrbD -1.0 -5.5 predicted ABC-type organic solvent transporter (NCBI) compare
b0677 nagA -1.0 -3.7 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b0564 appY -1.0 -0.9 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b1969 yedW -1.0 -2.5 putative 2-component transcriptional regulator (VIMSS) compare
b2258 b2258 -1.0 -1.2 putative transport/receptor protein (VIMSS) compare
b3443 yrhA -1.0 -1.2 orf, hypothetical protein (VIMSS) compare
b1161 ycgX -0.9 -0.6 hypothetical protein (NCBI) compare
b1575 dicB -0.9 -1.2 Qin prophage; cell division inhibition protein (NCBI) compare
b4146 yjeK -0.9 -0.9 predicted lysine aminomutase (NCBI) compare
b3026 qseC -0.9 -1.6 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b2011 sbcB -0.9 -5.1 exonuclease I (NCBI) compare
b2954 yggV -0.9 -3.3 putative deoxyribonucleotide triphosphate pyrophosphatase (NCBI) compare
b1286 rnb -0.9 -1.6 exoribonuclease II (NCBI) compare
b1251 yciI -0.9 -2.2 orf, hypothetical protein (VIMSS) compare
b3192 yrbC -0.9 -5.6 predicted ABC-type organic solvent transporter (NCBI) compare
b1503 ydeR -0.9 -1.8 predicted fimbrial-like adhesin protein (NCBI) compare
b3191 yrbB -0.9 -5.4 orf, hypothetical protein (VIMSS) compare
b0728 sucC -0.9 -3.5 succinyl-CoA synthetase subunit beta (NCBI) compare
b1175 minD -0.9 -2.9 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b3778 rep -0.9 -4.2 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b2188 yejM -0.9 -5.2 predicted hydrolase, inner membrane (NCBI) compare
b2822 recC -0.9 -2.4 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b2174 b2174 -0.9 -4.6 orf, hypothetical protein (VIMSS) compare
b2433 b2433 -0.9 -1.9 orf, hypothetical protein (VIMSS) compare
b3613 yibP -0.8 -1.4 putative membrane protein (VIMSS) compare
b3629 rfaS -0.8 -1.5 lipopolysaccharide core biosynthesis protein (NCBI) compare
b0436 tig -0.8 -4.5 trigger factor (NCBI) compare
b1270 btuR -0.8 -2.6 cob(I)yrinic acid a,c-diamide adenosyltransferase (NCBI) compare
b4239 treC -0.8 -1.2 trehalose-6-P hydrolase (NCBI) compare
b0912 ihfB -0.8 -2.0 integration host factor subunit beta (NCBI) compare
b2911 ssrS -0.8 -1.4 6S regulatory RNA (NCBI) compare
b2215 ompC -0.8 -4.6 outer membrane porin protein C (NCBI) compare
b3229 sspA -0.8 -1.7 stringent starvation protein A (NCBI) compare
b1579 intQ -0.8 -0.9 Qin prophage; predicted defective integrase (RefSeq) compare
b1855 lpxM -0.8 -3.0 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b2369 evgA -0.8 -1.5 DNA-binding response regulator in two-component regulatory system with EvgS (NCBI) compare
b3786 rffE -0.8 -6.1 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b3426 glpD -0.8 -2.2 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding (NCBI) compare
b0499 ylbH -0.8 -2.0 conserved protein, rhs-like (RefSeq) compare
b0784 moaD -0.8 -1.9 molybdopterin synthase, small subunit (NCBI) compare
b3392 yrfA -0.8 -3.3 orf, hypothetical protein (VIMSS) compare
b2531 iscR -0.8 -1.0 DNA-binding transcriptional repressor (NCBI) compare
b2774 ygcW -0.8 -1.8 putative oxidoreductase (VIMSS) compare
b2699 recA -0.8 -0.5 recombinase A (NCBI) compare
b3839 tatC -0.8 -3.8 TatABCE protein translocation system subunit (NCBI) compare
b3405 ompR -0.8 -2.6 osmolarity response regulator (NCBI) compare
b0729 sucD -0.7 -2.1 succinyl-CoA synthetase subunit alpha (NCBI) compare
b1536 ydeI -0.7 -0.5 hypothetical protein (NCBI) compare
b2637 yfjT -0.7 -2.0 CP4-57 prophage; predicted protein (NCBI) compare
b2494 yfgC -0.7 -3.8 predicted peptidase (NCBI) compare
b3836 b3836 -0.7 -2.0 orf, hypothetical protein (VIMSS) compare
b3626 rfaJ -0.7 -1.8 UDP-D-glucose:(galactosyl)lipopolysaccharide glucosyltransferase (NCBI) compare
b1309 ycjM -0.7 -1.6 putative polysaccharide hydrolase (VIMSS) compare
b3672 ivbL -0.7 -2.3 ilvB operon leader peptide (NCBI) compare
b1942 fliJ -0.7 -0.8 flagellar biosynthesis chaperone (NCBI) compare
b0741 pal -0.7 -1.7 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b1799 yeaT -0.7 -2.2 putative transcriptional regulator LYSR-type (VIMSS) compare
b1330 ynaI -0.7 -2.0 conserved inner membrane protein (NCBI) compare
b2237 inaA -0.7 -2.1 hypothetical protein (NCBI) compare
b2212 alkB -0.7 -2.6 oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions (NCBI) compare
b1268 yciQ -0.7 -3.5 predicted inner membrane protein (NCBI) compare
b2165 yeiN -0.7 -2.6 hypothetical protein (NCBI) compare
b1566 flxA -0.7 -1.3 Qin prophage; predicted protein (NCBI) compare
b1070 flgN -0.7 -0.8 export chaperone for FlgK and FlgL (NCBI) compare
b4698 mgrR -0.7 -1.4 sRNA antisense regulator down regulates YgdQ and EptB, PhoPQ-regulated, Hfq-dependent; affects sensitivity to antimicrobial peptides (RefSeq) compare
b1860 ruvB -0.7 -0.4 Holliday junction DNA helicase B (NCBI) compare
b4509 ylcG -0.7 -1.1 DLP12 prophage; predicted protein (NCBI) compare
b4620 yjbT -0.7 -2.8 hypothetical protein, no homologs (RefSeq) compare
b2553 glnB -0.6 -2.4 regulatory protein P-II for glutamine synthetase (NCBI) compare
b3129 sohA -0.6 -1.9 predicted regulator (NCBI) compare
b0460 hha -0.6 -2.0 modulator of gene expression, with H-NS (NCBI) compare
b1677 lpp -0.6 -1.0 murein lipoprotein (NCBI) compare
b3811 xerC -0.6 -0.9 site-specific tyrosine recombinase XerC (NCBI) compare
b1123 potD -0.6 -2.4 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b1670 ydhU -0.6 -1.9 predicted cytochrome (NCBI) compare
b1563 relE -0.6 -0.7 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b1324 tpx -0.6 -1.9 thiol peroxidase (NCBI) compare
b1754 b1754 -0.6 -1.4 orf, hypothetical protein (VIMSS) compare
b1333 uspE -0.6 -1.8 stress-induced protein (NCBI) compare
b1370 insH-5 -0.6 -1.4 Rac prophage; IS5 transposase and trans-activator (NCBI) compare
b1512 lsrR -0.6 -2.2 lsr operon transcriptional repressor (NCBI) compare
b0688 pgm -0.6 -1.5 phosphoglucomutase (NCBI) compare
b1785 yeaI -0.6 -1.0 predicted diguanylate cyclase (NCBI) compare
b1247 oppF -0.6 -1.7 oligopeptide transporter subunit (NCBI) compare
b0357 yaiN -0.6 -1.1 putative alpha helix chain (VIMSS) compare
b0764 modB -0.6 -2.2 molybdate ABC transporter permease protein (NCBI) compare
b2354 yfdK -0.6 -2.2 CPS-53 (KpLE1) prophage; conserved protein (NCBI) compare
b1217 chaB -0.6 -0.6 cation transport regulator (NCBI) compare
b4630 ykgP -0.6 -0.9 no description compare
b1109 ndh -0.6 -1.7 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b2005 yeeV -0.6 -1.5 CP4-44 prophage; toxin of the YeeV-YeeU toxin-antitoxin system (NCBI) compare
b1192 ldcA -0.6 -1.9 L,D-carboxypeptidase A (NCBI) compare
b3794 rffM -0.6 -3.1 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b0877 ybjX -0.6 -2.9 hypothetical protein (NCBI) compare
b3387 dam -0.6 -4.0 DNA adenine methylase (NCBI) compare
b3930 menA -0.6 -4.8 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b3237 argR -0.6 -1.9 arginine repressor (NCBI) compare
b1604 ydgH -0.6 -2.6 hypothetical protein (NCBI) compare
b1569 dicC -0.6 -1.7 Qin prophage; DNA-binding transcriptional regulator for DicB (NCBI) compare
b4640 yoeG -0.6 -1.0 no description compare
b1260 trpA -0.6 -2.3 tryptophan synthase subunit alpha (NCBI) compare
b0618 citC -0.6 -3.2 citrate lyase synthetase (citrate (pro-3S)-lyase ligase (VIMSS) compare
b0364 yaiS -0.6 -1.4 orf, hypothetical protein (VIMSS) compare
b4559 yjdO -0.6 -1.3 hypothetical protein (NCBI) compare
b1495 yddB -0.6 -3.1 predicted porin protein (NCBI) compare
b2195 ccmG -0.6 -1.0 periplasmic thioredoxin of cytochrome c-type biogenesis (NCBI) compare
b0009 mog -0.6 -2.9 molybdenum cofactor biosynthesis protein (NCBI) compare
b1614 ydgA -0.6 -1.6 hypothetical protein (NCBI) compare
b4614 sokA -0.6 -1.4 no description compare


Specific Phenotypes

For 5 genes in this experiment

For stress Nalidixic acid sodium salt in Escherichia coli BW25113

For stress Nalidixic acid sodium salt across organisms