Experiment set10IT056 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Oxytetracycline hydrochloride 0.00000015625 mM

200 most detrimental genes:

  gene name fitness t score description  
b1613 manA +1.3 3.0 mannose-6-phosphate isomerase (VIMSS) compare
b2279 nuoK +1.3 2.5 NADH dehydrogenase subunit K (NCBI) compare
b3860 dsbA +1.2 8.2 periplasmic protein disulfide isomerase I (NCBI) compare
b3500 gor +1.1 2.0 glutathione reductase (NCBI) compare
b1185 dsbB +1.1 3.4 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b2058 wcaB +1.1 1.6 predicted acyl transferase (NCBI) compare
b1111 ycfQ +1.1 3.9 orf, hypothetical protein (VIMSS) compare
b1556 b1556 +1.1 2.9 orf, hypothetical protein (VIMSS) compare
b2642 yfjW +1.0 1.4 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b0200 gmhB +1.0 1.4 hypothetical protein (NCBI) compare
b1231 tyrT +1.0 1.3 tRNA-Tyr (NCBI) compare
b4533 ynfO +0.9 1.5 Qin prophage; predicted protein (NCBI) compare
b3250 mreC +0.9 1.4 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b4451 ryhB +0.9 1.8 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b4538 yoeF +0.9 1.9 hypothetical protein (RefSeq) compare
b1293 sapB +0.9 1.2 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1332 ynaJ +0.8 0.7 predicted inner membrane protein (NCBI) compare
b1279 yciS +0.8 1.2 conserved inner membrane protein (NCBI) compare
b2951 yggS +0.8 3.7 predicted enzyme (NCBI) compare
b2912 ygfA +0.8 2.7 putative ligase (VIMSS) compare
b0247 ykfG +0.8 1.4 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b1751 ydjY +0.7 3.3 orf, hypothetical protein (VIMSS) compare
b4647 mokA +0.7 0.4 no description compare
b1143 ymfI +0.7 1.3 orf, hypothetical protein (VIMSS) compare
b2743 pcm +0.7 2.8 protein-L-isoaspartate O-methyltransferase (NCBI) compare
b4596 yciZ +0.7 1.6 hypothetical protein (RefSeq) compare
b1553 ydfP +0.7 2.1 Qin prophage; conserved protein (NCBI) compare
b4041 plsB +0.7 1.8 glycerol-3-phosphate acyltransferase (VIMSS) compare
b1842 holE +0.7 0.9 DNA polymerase III, theta subunit (NCBI) compare
b1090 plsX +0.7 2.9 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b2424 cysU +0.6 1.4 sulfate/thiosulfate transporter subunit (NCBI) compare
b0641 rlpB +0.6 1.3 minor lipoprotein (NCBI) compare
b1362 rzpR +0.6 1.5 putative Rac prophage endopeptidase (VIMSS) compare
b0926 ycbK +0.6 2.7 hypothetical protein (NCBI) compare
b1992 cobS +0.6 1.5 cobalamin synthase (NCBI) compare
b4241 treR +0.6 4.8 trehalose repressor (NCBI) compare
b3169 nusA +0.6 1.9 transcription elongation factor NusA (NCBI) compare
b1647 ydhF +0.6 2.3 predicted oxidoreductase (NCBI) compare
b2093 gatB +0.6 1.5 galactitol-specific enzyme IIB component of PTS (NCBI) compare
b0987 ymcD +0.6 2.9 orf, hypothetical protein (VIMSS) compare
b3863 polA +0.6 0.6 DNA polymerase I (NCBI) compare
b1593 b1593 +0.6 1.7 orf, hypothetical protein (VIMSS) compare
b2061 wzb +0.6 1.4 protein-tyrosine phosphatase (NCBI) compare
b4481 rffT +0.6 3.4 4-alpha-L-fucosyltransferase (NCBI) compare
b1656 sodB +0.6 1.9 superoxide dismutase, Fe (NCBI) compare
b4158 yjeO +0.5 2.3 conserved inner membrane protein (NCBI) compare
b2050 wcaI +0.5 1.8 predicted glycosyl transferase (NCBI) compare
b1942 fliJ +0.5 1.1 flagellar biosynthesis chaperone (NCBI) compare
b0418 pgpA +0.5 2.8 phosphatidylglycerophosphatase A (NCBI) compare
b1008 ycdI +0.5 2.4 hypothetical protein (NCBI) compare
b1582 ynfA +0.5 1.5 hypothetical protein (NCBI) compare
b1630 rsxD +0.5 2.7 electron transport complex protein RnfD (NCBI) compare
b1581 rspA +0.5 1.9 predicted dehydratase (NCBI) compare
b4578 insP +0.5 1.6 no description compare
b0219 yafV +0.5 1.9 predicted C-N hydrolase family amidase, NAD(P)-binding (NCBI) compare
b2096 gatY +0.5 1.9 tagatose-bisphosphate aldolase 1 (VIMSS) compare
b4523 yciX +0.5 1.7 hypothetical protein (RefSeq) compare
b2134 pbpG +0.5 2.7 penicillin-binding protein 7 (VIMSS) compare
b0346 mhpR +0.5 2.4 DNA-binding transcriptional activator, 3HPP-binding (RefSeq) compare
b1804 rnd +0.5 1.8 ribonuclease D (NCBI) compare
b0685 ybfE +0.5 1.3 orf, hypothetical protein (VIMSS) compare
b1563 relE +0.5 1.0 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b3791 rffA +0.5 3.2 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b0065 yabI +0.5 2.3 conserved inner membrane protein (NCBI) compare
b1963 b1963 +0.5 2.1 orf, hypothetical protein (VIMSS) compare
b3977 tyrU +0.5 0.5 tRNA-Tyr (NCBI) compare
b4403 yjtD +0.5 2.7 predicted rRNA methyltransferase (NCBI) compare
b1524 yneH +0.5 0.5 predicted glutaminase (NCBI) compare
b1632 rsxE +0.5 2.9 NADH-ubiquinone oxidoreductase (NCBI) compare
b1565 ydfV +0.5 1.8 Qin prophage; predicted protein (NCBI) compare
b2910 zapA +0.5 1.8 protein that localizes to the cytokinetic ring (NCBI) compare
b1266 yciV +0.5 1.4 hypothetical protein (NCBI) compare
b3658 selC +0.5 0.7 tRNA-Sec (NCBI) compare
b2285 nuoE +0.5 0.8 NADH dehydrogenase subunit E (NCBI) compare
b3181 greA +0.5 1.7 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b0550 rusA +0.5 1.4 DLP12 prophage; endonuclease RUS (NCBI) compare
b1151 ymfO +0.4 1.7 e14 prophage; conserved protein (RefSeq) compare
b1757 b1757 +0.4 1.7 putative thiosulfate sulfur transferase (VIMSS) compare
b2617 smpA +0.4 1.1 small membrane protein A (VIMSS) compare
b0542 renD +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b4589 ylcI +0.4 1.2 hypothetical protein (RefSeq) compare
b1312 ycjP +0.4 2.5 predicted sugar transporter subunit: membrane component of ABC superfamily (NCBI) compare
b2298 yfcC +0.4 2.6 putative S-transferase (VIMSS) compare
b4410 ecnA +0.4 0.9 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b1743 spy +0.4 2.1 envelope stress induced periplasmic protein (NCBI) compare
b1394 paaG +0.4 1.3 enoyl-CoA hydratase (NCBI) compare
b0464 acrR +0.4 3.2 DNA-binding transcriptional repressor (NCBI) compare
b3027 ygiZ +0.4 0.2 conserved inner membrane protein (NCBI) compare
b1262 trpC +0.4 2.4 N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) compare
b0798 ybiA +0.4 1.2 hypothetical protein (NCBI) compare
b0496 ybbP +0.4 3.1 predicted inner membrane protein (NCBI) compare
b0249 ykfF +0.4 0.9 CP4-6 prophage; predicted protein (NCBI) compare
b2258 b2258 +0.4 0.8 putative transport/receptor protein (VIMSS) compare
b1548 nohA +0.4 0.9 Qin prophage; predicted packaging protein (RefSeq) compare
b0632 dacA +0.4 2.7 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b2783 chpR +0.4 0.8 antitoxin of the ChpA-ChpR toxin-antitoxin system (NCBI) compare
b0964 yccT +0.4 2.0 hypothetical protein (NCBI) compare
b2187 yejL +0.4 1.3 hypothetical protein (NCBI) compare
b1603 pntA +0.4 1.2 NAD(P) transhydrogenase subunit alpha (NCBI) compare
b2704 srlB +0.4 1.4 glucitol/sorbitol-specific enzyme IIA component of PTS (NCBI) compare
b0520 ylbF +0.4 1.8 hypothetical protein (NCBI) compare
b2266 elaB +0.4 1.6 hypothetical protein (NCBI) compare
b1806 yeaY +0.4 1.6 predicted lipoprotein (NCBI) compare
b3068 ygjF +0.4 1.5 G/U mismatch-specific DNA glycosylase (NCBI) compare
b3057 bacA +0.4 2.2 undecaprenyl pyrophosphate phosphatase (NCBI) compare
b3790 rffC +0.4 2.0 TDP-fucosamine acetyltransferase (RefSeq) compare
b1763 topB +0.4 1.5 DNA topoisomerase III (NCBI) compare
b1803 yeaX +0.4 1.3 predicted oxidoreductase (NCBI) compare
b0018 mokC +0.4 0.7 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b1620 malI +0.4 0.8 DNA-binding transcriptional repressor (NCBI) compare
b2236 yfaE +0.4 1.0 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b2899 yqfA +0.4 2.2 predicted oxidoreductase, inner membrane subunit (NCBI) compare
b2095 gatZ +0.4 1.9 D-tagatose 1,6-bisphosphate aldolase 2, subunit (NCBI) compare
b0843 ybjH +0.4 1.1 hypothetical protein (NCBI) compare
b3101 yqjF +0.4 0.8 orf, hypothetical protein (VIMSS) compare
b4585 sroB +0.4 0.6 Novel sRNA, function unknown (RefSeq) compare
b2749 ygbE +0.4 2.1 conserved inner membrane protein (NCBI) compare
b3471 yhhQ +0.4 2.6 conserved inner membrane protein (NCBI) compare
b1292 sapC +0.4 0.7 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1959 yedA +0.4 1.4 predicted inner membrane protein (NCBI) compare
b3242 yhcR +0.4 2.2 orf, hypothetical protein (VIMSS) compare
b1289 ycjD +0.4 1.4 hypothetical protein (NCBI) compare
b1682 sufC +0.4 1.8 cysteine desulfurase ATPase component (NCBI) compare
b1219 ychN +0.4 1.1 hypothetical protein (NCBI) compare
b0015 dnaJ +0.4 2.5 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b1907 tyrP +0.4 1.3 tyrosine transporter (NCBI) compare
b0191 yaeJ +0.4 1.6 hypothetical protein (NCBI) compare
b3033 yqiB +0.4 1.8 predicted dehydrogenase (NCBI) compare
b1278 pgpB +0.4 0.7 phosphatidylglycerophosphatase B (NCBI) compare
b3190 yrbA +0.4 1.8 orf, hypothetical protein (VIMSS) compare
b1350 recE +0.4 2.0 Rac prophage; exonuclease VIII, 5' -> 3' specific dsDNA exonuclease (NCBI) compare
b1462 b1462 +0.4 1.2 orf, hypothetical protein (VIMSS) compare
b2080 b2080 +0.4 0.9 orf, hypothetical protein (VIMSS) compare
b4655 ythA +0.4 0.6 expressed protein (RefSeq) compare
b1993 cobU +0.4 1.7 adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase (NCBI) compare
b0767 ybhE +0.4 1.4 6-phosphogluconolactonase (NCBI) compare
b0720 gltA +0.4 2.1 citrate synthase (NCBI) compare
b2690 yqaB +0.4 2.2 predicted hydrolase (NCBI) compare
b0875 aqpZ +0.4 2.0 aquaporin Z (NCBI) compare
b1625 ydgT +0.4 2.0 predicted regulator (NCBI) compare
b2708 gutQ +0.4 1.6 orf, hypothetical protein (VIMSS) compare
b2906 visC +0.4 1.9 hypothetical protein (NCBI) compare
b1336 ydaH +0.4 1.2 putative pump protein (transport) (VIMSS) compare
b4650 yibS +0.4 0.7 no description compare
b2195 ccmG +0.4 0.9 periplasmic thioredoxin of cytochrome c-type biogenesis (NCBI) compare
b3290 trkA +0.4 0.7 potassium transporter peripheral membrane component (NCBI) compare
b2597 yfiA +0.4 0.8 cold shock protein associated with 30S ribosomal subunit (NCBI) compare
b1217 chaB +0.4 0.4 cation transport regulator (NCBI) compare
b2044 wcaL +0.4 1.3 predicted glycosyl transferase (NCBI) compare
b2765 ygcM +0.3 1.5 6-pyruvoyl tetrahydrobiopterin synthase (PTPS) (NCBI) compare
b1349 recT +0.3 1.8 Rac prophage; recombination and repair protein (NCBI) compare
b0721 sdhC +0.3 1.2 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b2634 yfjR +0.3 1.3 CP4-57 prophage; predicted DNA-binding transcriptional regulator (NCBI) compare
b2741 rpoS +0.3 1.8 RNA polymerase sigma factor (NCBI) compare
b1424 mdoD +0.3 1.6 glucan biosynthesis protein, periplasmic (RefSeq) compare
b1602 pntB +0.3 1.4 pyridine nucleotide transhydrogenase (NCBI) compare
b3794 rffM +0.3 2.1 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b2288 nuoA +0.3 1.0 NADH dehydrogenase I chain A (VIMSS) compare
b3024 ygiW +0.3 1.3 hypothetical protein (NCBI) compare
b0920 ycbC +0.3 1.6 conserved inner membrane protein (NCBI) compare
b1855 lpxM +0.3 1.3 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b0713 ybgL +0.3 1.2 hypothetical protein (NCBI) compare
b0578 nfnB +0.3 1.8 dihydropteridine reductase, NAD(P)H-dependent, oxygen-insensitive (NCBI) compare
b0097 yacA +0.3 1.1 orf, hypothetical protein (VIMSS) compare
b1431 ydcL +0.3 1.3 predicted lipoprotein (NCBI) compare
b0127 yadG +0.3 1.8 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b1892 flhD +0.3 1.4 DNA-binding transcriptional dual regulator with FlhC (RefSeq) compare
b0407 yajC +0.3 0.9 preprotein translocase subunit YajC (NCBI) compare
b0982 yccY +0.3 1.7 putative phosphatase (VIMSS) compare
b3127 garP +0.3 1.9 predicted (D)-galactarate transporter (NCBI) compare
b1728 ydjM +0.3 1.0 predicted inner membrane protein regulated by LexA (RefSeq) compare
b0796 ybiH +0.3 1.2 putative transcriptional regulator (VIMSS) compare
b2947 gshB +0.3 1.2 glutathione synthetase (NCBI) compare
b2666 yqaE +0.3 1.5 predicted membrane protein (NCBI) compare
b3632 rfaQ +0.3 2.9 lipopolysaccharide core biosynthesis protein (NCBI) compare
b4577 sgrS +0.3 0.8 small antisense RNA (NCBI) compare
b1355 b1355 +0.3 0.7 orf, hypothetical protein (VIMSS) compare
b0807 ybiN +0.3 2.0 orf, hypothetical protein (VIMSS) compare
b1135 ymfC +0.3 1.7 orf, hypothetical protein (VIMSS) compare
b1271 yciK +0.3 1.1 short chain dehydrogenase (NCBI) compare
b0368 tauD +0.3 1.2 taurine dioxygenase (NCBI) compare
b2916 argP +0.3 1.6 chromosome replication initiation inhibitor protein (NCBI) compare
b1704 aroH +0.3 1.5 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible (NCBI) compare
b1587 ynfE +0.3 2.0 oxidoreductase subunit (NCBI) compare
b0493 ybbO +0.3 1.4 short chain dehydrogenase (NCBI) compare
b0523 purE +0.3 1.2 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b0549 ybcO +0.3 0.9 DLP12 prophage; predicted protein (NCBI) compare
b0230 mbhA +0.3 1.9 putative motility protein (VIMSS) compare
b0696 kdpC +0.3 0.9 potassium-transporting ATPase subunit C (NCBI) compare
b3858 yihD +0.3 1.0 hypothetical protein (NCBI) compare
b2422 cysA +0.3 1.9 sulfate/thiosulfate transporter subunit (NCBI) compare
b2813 mltA +0.3 2.3 membrane-bound lytic murein transglycosylase A (NCBI) compare
b2771 ygcS +0.3 1.7 putative transport protein (VIMSS) compare
b2213 ada +0.3 1.3 fused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase (NCBI) compare
b0751 pnuC +0.3 1.7 predicted nicotinamide mononucleotide transporter (NCBI) compare
b2171 yeiP +0.3 1.5 putative elongation factor (VIMSS) compare
b2432 yfeY +0.3 0.8 hypothetical protein (NCBI) compare
b1843 yobB +0.3 1.5 hypothetical protein (NCBI) compare
b4394 yjjX +0.3 0.7 orf, hypothetical protein (VIMSS) compare
b1931 yedK +0.3 1.1 hypothetical protein (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress Oxytetracycline hydrochloride across organisms