Experiment set10IT054 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Spiramycin 0.00003125 mM

200 most important genes:

  gene name fitness t score description  
b0463 acrA -4.9 -10.9 multidrug efflux system (NCBI) compare
b0462 acrB -4.7 -17.5 multidrug efflux system protein (NCBI) compare
b0903 pflB -4.4 -12.7 pyruvate formate lyase I (NCBI) compare
b3163 nlpI -4.1 -4.0 hypothetical protein (NCBI) compare
b4509 ylcG -3.9 -3.8 DLP12 prophage; predicted protein (NCBI) compare
b0902 pflA -3.9 -9.0 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b0677 nagA -3.7 -5.6 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b2512 yfgL -3.7 -6.5 protein assembly complex, lipoprotein component (NCBI) compare
b1334 fnr -3.6 -3.4 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b3035 tolC -3.5 -8.5 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b2188 yejM -3.5 -11.4 predicted hydrolase, inner membrane (NCBI) compare
b4025 pgi -3.3 -8.6 glucose-6-phosphate isomerase (NCBI) compare
b3620 rfaF -3.3 -5.0 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b3052 rfaE -3.2 -3.8 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b0145 dksA -3.1 -3.0 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b0053 surA -3.1 -2.1 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b0222 lpcA -3.0 -2.9 phosphoheptose isomerase (NCBI) compare
b2617 smpA -2.9 -4.3 small membrane protein A (VIMSS) compare
b3842 rfaH -2.9 -6.4 transcriptional activator RfaH (NCBI) compare
b3341 rpsG -2.8 -1.9 30S ribosomal protein S7 (NCBI) compare
b1830 prc -2.8 -5.2 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b3199 yrbK -2.7 -3.6 hypothetical protein (NCBI) compare
b0178 hlpA -2.7 -5.3 periplasmic chaperone (NCBI) compare
b2620 smpB -2.6 -1.8 SsrA-binding protein (NCBI) compare
b2501 ppk -2.6 -10.1 polyphosphate kinase (NCBI) compare
b3631 rfaG -2.6 -11.9 glucosyltransferase I (NCBI) compare
b2494 yfgC -2.6 -8.7 predicted peptidase (NCBI) compare
b0239 frsA -2.4 -10.3 fermentation/respiration switch protein (NCBI) compare
b3621 rfaC -2.4 -4.3 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b4237 nrdG -2.4 -10.2 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b4535 yniD -2.4 -1.6 predicted protein (RefSeq) compare
b3632 rfaQ -2.4 -16.3 lipopolysaccharide core biosynthesis protein (NCBI) compare
b1831 proQ -2.3 -5.7 putative solute/DNA competence effector (NCBI) compare
b3630 rfaP -2.3 -7.8 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b0739 tolA -2.2 -2.1 cell envelope integrity inner membrane protein TolA (NCBI) compare
b4238 nrdD -2.2 -15.2 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b4701 sokX -2.2 -1.5 sok-related sRNA, function unknown (RefSeq) compare
b3198 kdsC -2.2 -4.3 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b3619 rfaD -2.2 -2.9 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b0014 dnaK -2.1 -2.0 molecular chaperone DnaK (NCBI) compare
b1677 lpp -2.1 -2.7 murein lipoprotein (NCBI) compare
b0957 ompA -2.1 -2.9 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b0741 pal -2.0 -3.7 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b1236 galU -2.0 -3.7 glucose-1-phosphate uridylyltransferase (NCBI) compare
b3021 ygiT -1.9 -2.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b4631 ykgQ -1.9 -2.5 no description compare
b1863 ruvC -1.9 -2.1 Holliday junction resolvase (NCBI) compare
b2064 asmA -1.9 -3.3 predicted assembly protein (NCBI) compare
b4592 yccB -1.8 -2.1 hypothetical protein (RefSeq) compare
b3930 menA -1.7 -12.0 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b2363 yfdT -1.7 -2.9 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b0688 pgm -1.7 -3.4 phosphoglucomutase (NCBI) compare
b1847 yebF -1.7 -1.9 predicted protein (RefSeq) compare
b1530 marR -1.6 -4.8 multiple antibiotic resistance protein; repressor of mar operon (VIMSS) compare
b1855 lpxM -1.6 -5.1 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b0783 moaC -1.6 -5.7 molybdenum cofactor biosynthesis protein C (NCBI) compare
b0740 tolB -1.6 -3.7 translocation protein TolB precursor (NCBI) compare
b0738 tolR -1.6 -1.8 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0436 tig -1.6 -7.4 trigger factor (NCBI) compare
b1936 intG -1.6 -1.0 predicted defective phage integrase (pseudogene) (RefSeq) compare
b1861 ruvA -1.6 -1.0 Holliday junction DNA helicase motor protein (NCBI) compare
b4603 rseX -1.5 -1.1 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b2830 nudH -1.5 -1.4 dinucleoside polyphosphate hydrolase (NCBI) compare
b3443 yrhA -1.5 -1.7 orf, hypothetical protein (VIMSS) compare
b0706 ybfD -1.5 -1.4 hypothetical protein (NCBI) compare
b3229 sspA -1.5 -2.4 stringent starvation protein A (NCBI) compare
b0049 apaH -1.5 -2.8 diadenosinetetraphosphatase (NCBI) compare
b3390 aroK -1.5 -2.1 shikimate kinase I (NCBI) compare
b1493 gadB -1.5 -1.0 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b2576 srmB -1.5 -2.3 ATP-dependent RNA helicase (NCBI) compare
b1259 yciG -1.5 -1.6 orf, hypothetical protein (VIMSS) compare
b1823 cspC -1.4 -1.6 stress protein, member of the CspA-family (NCBI) compare
b1550 b1550 -1.4 -1.6 orf, hypothetical protein (VIMSS) compare
b3839 tatC -1.4 -5.7 TatABCE protein translocation system subunit (NCBI) compare
b2528 iscA -1.4 -1.8 iron-sulfur cluster assembly protein (NCBI) compare
b3636 rpmG -1.3 -1.9 50S ribosomal protein L33 (NCBI) compare
b1150 ymfR -1.3 -1.1 e14 prophage; predicted protein (NCBI) compare
b0890 ftsK -1.3 -2.1 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b2168 fruK -1.3 -1.1 1-phosphofructokinase (NCBI) compare
b2567 rnc -1.3 -0.8 ribonuclease III (NCBI) compare
b4221 ytfN -1.3 -10.6 hypothetical protein (NCBI) compare
b3405 ompR -1.3 -3.8 osmolarity response regulator (NCBI) compare
b4503 yafF -1.3 -0.8 no description compare
b3761 trpT -1.3 -1.6 tRNA-Trp (NCBI) compare
b1361 ydaW -1.3 -0.9 orf, hypothetical protein (VIMSS) compare
b1161 ycgX -1.3 -0.8 hypothetical protein (NCBI) compare
b0226 dinJ -1.3 -4.4 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b0001 thrL -1.3 -2.7 thr operon leader peptide (NCBI) compare
b0730 mngR -1.3 -1.4 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b0364 yaiS -1.3 -2.4 orf, hypothetical protein (VIMSS) compare
b4676 yoaK -1.3 -0.8 expressed protein (RefSeq) compare
b1335 ogt -1.3 -2.8 O-6-alkylguanine-DNA:cysteine-protein methyltransferase (NCBI) compare
b3627 rfaI -1.2 -6.1 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b2553 glnB -1.2 -4.1 regulatory protein P-II for glutamine synthetase (NCBI) compare
b4201 priB -1.2 -2.4 primosomal replication protein N (NCBI) compare
b1346 ydaQ -1.2 -1.3 orf, hypothetical protein (VIMSS) compare
b2935 tktA -1.2 -0.8 transketolase 1, thiamin-binding (NCBI) compare
b3726 pstA -1.2 -3.5 phosphate transporter subunit (NCBI) compare
b2894 xerD -1.2 -0.8 site-specific tyrosine recombinase XerD (NCBI) compare
b3609 secB -1.2 -3.5 export protein SecB (NCBI) compare
b0200 gmhB -1.2 -0.8 hypothetical protein (NCBI) compare
b0827 moeA -1.2 -4.5 molybdopterin biosynthesis protein (NCBI) compare
b0785 moaE -1.2 -4.6 molybdopterin synthase, large subunit (NCBI) compare
b1368 ynaA -1.2 -2.0 Rac prophage; predicted tail protein (RefSeq) compare
b0232 yafN -1.2 -0.7 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b0564 appY -1.2 -1.1 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b2141 yohJ -1.2 -2.8 hypothetical protein (NCBI) compare
b2808 gcvA -1.2 -2.8 DNA-binding transcriptional dual regulator (NCBI) compare
b0847 ybjL -1.2 -6.7 hypothetical protein (NCBI) compare
b0547 ybcN -1.2 -2.4 DLP12 prophage; predicted protein (NCBI) compare
b3387 dam -1.1 -7.0 DNA adenine methylase (NCBI) compare
b2820 recB -1.1 -0.8 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b4220 ytfM -1.1 -7.4 predicted outer membrane protein and surface antigen (NCBI) compare
b2369 evgA -1.1 -1.9 DNA-binding response regulator in two-component regulatory system with EvgS (NCBI) compare
b0929 ompF -1.1 -4.0 outer membrane porin 1a (Ia;b;F) (NCBI) compare
b1730 ydjO -1.1 -0.7 predicted protein (RefSeq) compare
b0357 yaiN -1.1 -2.0 putative alpha helix chain (VIMSS) compare
b1124 potC -1.1 -4.2 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b2531 iscR -1.1 -1.0 DNA-binding transcriptional repressor (NCBI) compare
b3600 mtlD -1.1 -5.8 mannitol-1-phosphate 5-dehydrogenase (NCBI) compare
b0548 ninE -1.1 -2.0 DLP12 prophage; conserved protein (NCBI) compare
b4375 prfC -1.1 -1.9 peptide chain release factor 3 (NCBI) compare
b3644 yicC -1.1 -4.5 hypothetical protein (NCBI) compare
b0423 thiI -1.1 -4.0 thiamine biosynthesis protein ThiI (NCBI) compare
b1542 ydfI -1.1 -3.4 predicted mannonate dehydrogenase (NCBI) compare
b3857 mobA -1.1 -5.1 molybdopterin-guanine dinucleotide biosynthesis protein A (NCBI) compare
b4146 yjeK -1.1 -0.7 predicted lysine aminomutase (NCBI) compare
b2215 ompC -1.1 -5.9 outer membrane porin protein C (NCBI) compare
b1676 pykF -1.1 -2.9 pyruvate kinase (NCBI) compare
b4000 hupA -1.1 -3.8 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b4585 sroB -1.0 -1.1 Novel sRNA, function unknown (RefSeq) compare
b0707 ybgA -1.0 -3.3 hypothetical protein (NCBI) compare
b4239 treC -1.0 -1.0 trehalose-6-P hydrolase (NCBI) compare
b0764 modB -1.0 -3.4 molybdate ABC transporter permease protein (NCBI) compare
b0949 uup -1.0 -5.5 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1273 yciN -1.0 -1.6 hypothetical protein (NCBI) compare
b2085 b2085 -1.0 -2.4 orf, hypothetical protein (VIMSS) compare
b4480 hdfR -1.0 -4.0 transcriptional regulator HdfR (NCBI) compare
b2572 rseA -1.0 -2.9 anti-sigma factor (NCBI) compare
b4570 lomR -1.0 -1.0 no description compare
b2569 lepA -1.0 -2.5 GTP-binding protein LepA (NCBI) compare
b0009 mog -1.0 -5.5 molybdenum cofactor biosynthesis protein (NCBI) compare
b2252 ais -1.0 -2.9 hypothetical protein (NCBI) compare
b0765 modC -1.0 -4.0 molybdate transporter subunit (NCBI) compare
b1291 sapD -1.0 -1.4 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1862 yebB -1.0 -2.1 orf, hypothetical protein (VIMSS) compare
b0781 moaA -1.0 -4.3 molybdenum cofactor biosynthesis protein A (NCBI) compare
b1951 rcsA -1.0 -0.7 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b3916 pfkA -1.0 -1.4 6-phosphofructokinase (NCBI) compare
b3587 yiaW -1.0 -3.6 conserved inner membrane protein (NCBI) compare
b3250 mreC -1.0 -1.6 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b3778 rep -1.0 -4.4 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b4416 rybA -1.0 -1.2 unknown RNA (NCBI) compare
b0623 cspE -1.0 -1.6 cold shock protein E (NCBI) compare
b1877 yecT -1.0 -1.1 orf, hypothetical protein (VIMSS) compare
b4431 rprA -1.0 -1.3 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b2142 yohK -1.0 -3.7 predicted inner membrane protein (NCBI) compare
b1126 potA -1.0 -4.7 putrescine/spermidine ABC transporter ATPase protein (NCBI) compare
b3811 xerC -0.9 -0.6 site-specific tyrosine recombinase XerC (NCBI) compare
b1739 osmE -0.9 -2.0 DNA-binding transcriptional activator (NCBI) compare
b0141 yadN -0.9 -3.6 predicted fimbrial-like adhesin protein (NCBI) compare
b0729 sucD -0.9 -2.8 succinyl-CoA synthetase subunit alpha (NCBI) compare
b3764 yifE -0.9 -3.4 hypothetical protein (NCBI) compare
b0826 moeB -0.9 -4.4 molybdopterin biosynthesis protein MoeB (NCBI) compare
b3082 ygjM -0.9 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b3469 zntA -0.9 -4.4 zinc, cobalt and lead efflux system (NCBI) compare
b2433 b2433 -0.9 -2.0 orf, hypothetical protein (VIMSS) compare
b1824 yobF -0.9 -2.1 hypothetical protein (NCBI) compare
b2330 yfcB -0.9 -1.2 putative adenine-specific methylase (VIMSS) compare
b1249 cls -0.9 -4.3 cardiolipin synthetase (NCBI) compare
b1021 ycdP -0.9 -3.2 predicted inner membrane protein (NCBI) compare
b1429 tehA -0.9 -0.9 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b1536 ydeI -0.9 -0.6 hypothetical protein (NCBI) compare
b3963 fabR -0.9 -5.5 DNA-binding transcriptional repressor (RefSeq) compare
b1506 yneL -0.9 -0.7 predicted transcriptional regulator (NCBI) compare
b1241 adhE -0.9 -5.6 fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase (NCBI) compare
b0868 b0868 -0.9 -4.9 putative nucleotide di-P-sugar epimerase or dehydratase (VIMSS) compare
b1567 intK -0.9 -1.8 Qin prophage; predicted protein (RefSeq) compare
b0460 hha -0.9 -2.7 modulator of gene expression, with H-NS (NCBI) compare
b4101 phnG -0.9 -2.6 carbon-phosphorus lyase complex subunit (NCBI) compare
b4179 vacB -0.9 -3.2 putative enzyme (VIMSS) compare
b0904 focA -0.9 -3.2 formate transporter (NCBI) compare
b1278 pgpB -0.9 -1.9 phosphatidylglycerophosphatase B (NCBI) compare
b1160 elbA -0.9 -0.5 hypothetical protein (NCBI) compare
b1454 yncG -0.8 -1.6 predicted enzyme (NCBI) compare
b4181 yjfI -0.8 -1.8 hypothetical protein (NCBI) compare
b3649 rpoZ -0.8 -1.5 DNA-directed RNA polymerase subunit omega (NCBI) compare
b4699 fnrS -0.8 -0.7 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b1176 minC -0.8 -2.0 septum formation inhibitor (NCBI) compare
b1557 cspB -0.8 -1.4 Qin prophage; cold shock protein (NCBI) compare
b2017 yefM -0.8 -1.3 orf, hypothetical protein (VIMSS) compare
b1357 ydaS -0.8 -1.7 Rac prophage; predicted DNA-binding transcriptional regulator (NCBI) compare
b3628 rfaB -0.8 -4.5 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b3999 yjaG -0.8 -3.1 hypothetical protein (NCBI) compare
b2241 glpA -0.8 -5.7 sn-glycerol-3-phosphate dehydrogenase (anaerobic), large subunit, FAD/NAD(P)-binding (NCBI) compare
b1572 ydfB -0.8 -1.3 orf, hypothetical protein (VIMSS) compare
b1159 mcrA -0.8 -0.5 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b1860 ruvB -0.8 -0.5 Holliday junction DNA helicase B (NCBI) compare
b2271 yfbL -0.8 -3.3 putative aminopeptidase (VIMSS) compare
b0082 mraW -0.8 -1.8 S-adenosyl-methyltransferase (NCBI) compare


Specific Phenotypes

For 2 genes in this experiment

For stress Spiramycin in Escherichia coli BW25113

For stress Spiramycin across organisms