Experiment set10IT038 for Escherichia coli BW25113

Compare to:

LB Aerobic with Sulfamonomethoxine 0.000125 mM

200 most detrimental genes:

  gene name fitness t score description  
b2259 pmrD +1.1 1.6 polymyxin resistance protein B (VIMSS) compare
b4699 fnrS +0.9 1.1 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b1712 ihfA +0.9 1.3 integration host factor subunit alpha (NCBI) compare
b1358 ydaT +0.9 1.4 Rac prophage; predicted protein (NCBI) compare
b1984 asnW +0.8 1.6 tRNA-Asn (NCBI) compare
b1380 ldhA +0.8 2.4 D-lactate dehydrogenase (NCBI) compare
b2684 mprA +0.8 3.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b4695 ykgT +0.8 1.4 no description compare
b2044 wcaL +0.8 4.0 predicted glycosyl transferase (NCBI) compare
b3183 obgE +0.8 1.0 GTPase involved in cell partioning and DNA repair (NCBI) compare
b0912 ihfB +0.8 2.8 integration host factor subunit beta (NCBI) compare
b1607 ydgC +0.8 1.5 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b4647 mokA +0.8 0.4 no description compare
b4373 rimI +0.8 1.7 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b1362 rzpR +0.7 2.0 putative Rac prophage endopeptidase (VIMSS) compare
b1263 trpD +0.7 2.2 bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) compare
b4418 sraB +0.7 1.1 unknown RNA (NCBI) compare
b0580 ybdJ +0.7 1.9 predicted inner membrane protein (NCBI) compare
b1811 yoaH +0.7 2.6 hypothetical protein (NCBI) compare
b2187 yejL +0.7 2.3 hypothetical protein (NCBI) compare
b1667 ydhR +0.7 1.5 hypothetical protein (NCBI) compare
b3649 rpoZ +0.7 1.9 DNA-directed RNA polymerase subunit omega (NCBI) compare
b4360 yjjA +0.6 1.6 putative glycoprotein/receptor (VIMSS) compare
b1334 fnr +0.6 1.7 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b0101 yacG +0.6 2.5 zinc-binding protein (NCBI) compare
b0263 afuB +0.6 1.3 CP4-6 prophage; predicted ferric trasnporter subunit (RefSeq) compare
b0753 ybgS +0.6 2.1 hypothetical protein (NCBI) compare
b1524 yneH +0.6 0.7 predicted glutaminase (NCBI) compare
b1038 csgF +0.6 1.8 predicted transport protein (NCBI) compare
b1823 cspC +0.6 1.3 stress protein, member of the CspA-family (NCBI) compare
b0778 bioD +0.6 2.3 dethiobiotin synthetase (NCBI) compare
b0641 rlpB +0.6 1.8 minor lipoprotein (NCBI) compare
b1921 fliZ +0.6 1.7 orf, hypothetical protein (VIMSS) compare
b3239 yhcO +0.6 2.3 predicted barnase inhibitor (NCBI) compare
b2419 yfeK +0.6 0.9 hypothetical protein (NCBI) compare
b1526 yneJ +0.6 1.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b4155 yjeA +0.6 0.5 putative lysyl-tRNA synthetase (VIMSS) compare
b1606 folM +0.6 3.0 short chain dehydrogenase (NCBI) compare
b2765 ygcM +0.5 2.3 6-pyruvoyl tetrahydrobiopterin synthase (PTPS) (NCBI) compare
b1609 rstB +0.5 2.2 sensory histidine kinase in two-component regulatory system with RstA (NCBI) compare
b4585 sroB +0.5 0.9 Novel sRNA, function unknown (RefSeq) compare
b2377 yfdY +0.5 1.8 predicted inner membrane protein (NCBI) compare
b3658 selC +0.5 1.7 tRNA-Sec (NCBI) compare
b1901 araF +0.5 2.6 L-arabinose transporter subunit (NCBI) compare
b1699 ydiS +0.5 2.2 predicted oxidoreductase with FAD/NAD(P)-binding domain (NCBI) compare
b1233 ychJ +0.5 2.3 hypothetical protein (NCBI) compare
b1593 b1593 +0.5 2.0 orf, hypothetical protein (VIMSS) compare
b1751 ydjY +0.5 1.7 orf, hypothetical protein (VIMSS) compare
b4692 oweE +0.5 1.7 no description compare
b3611 yibN +0.5 2.4 predicted rhodanese-related sulfurtransferase (NCBI) compare
b1147 ymfL +0.5 1.5 e14 prophage; predicted DNA-binding transcriptional regulator (RefSeq) compare
b1151 ymfO +0.5 1.9 e14 prophage; conserved protein (RefSeq) compare
b1161 ycgX +0.5 0.6 hypothetical protein (NCBI) compare
b2614 grpE +0.5 1.1 heat shock protein (NCBI) compare
b0504 ybbS +0.5 2.0 DNA-binding transcriptional activator of the allD operon (NCBI) compare
b1305 pspB +0.5 1.6 phage shock protein B (NCBI) compare
b2398 yfeC +0.5 1.8 orf, hypothetical protein (VIMSS) compare
b0010 yaaH +0.5 2.3 conserved inner membrane protein associated with acetate transport (NCBI) compare
b1253 yciA +0.5 1.7 predicted hydrolase (NCBI) compare
b1640 ydhH +0.5 1.3 anhydro-N-acetylmuramic acid kinase (NCBI) compare
b2707 srlR +0.5 2.4 DNA-bindng transcriptional repressor (NCBI) compare
b1827 kdgR +0.5 1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b1180 ycgM +0.5 2.0 predicted isomerase/hydrolase (NCBI) compare
b0851 nfsA +0.5 2.5 nitroreductase A, NADPH-dependent, FMN-dependent (NCBI) compare
b2432 yfeY +0.5 1.1 hypothetical protein (NCBI) compare
b2940 yqgC +0.5 2.0 hypothetical protein (NCBI) compare
b0389 yaiA +0.5 1.4 hypothetical protein (NCBI) compare
b4592 yccB +0.5 0.5 hypothetical protein (RefSeq) compare
b2229 b2229 +0.5 1.6 orf, hypothetical protein (VIMSS) compare
b2579 yfiD +0.5 0.7 pyruvate formate lyase subunit (NCBI) compare
b1183 umuD +0.5 1.2 DNA polymerase V, subunit D (NCBI) compare
b2193 narP +0.5 2.4 DNA-binding response regulator in two-component regulatory system with NarQ or NarX (NCBI) compare
b0926 ycbK +0.5 2.4 hypothetical protein (NCBI) compare
b3148 yraN +0.5 1.4 hypothetical protein (NCBI) compare
b1006 ycdG +0.5 2.3 putative transport protein (VIMSS) compare
b3029 ygiN +0.5 1.4 quinol monooxygenase (NCBI) compare
b2300 yfcE +0.5 1.6 orf, hypothetical protein (VIMSS) compare
b1642 slyA +0.4 0.8 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b3119 tdcR +0.4 1.0 threonine dehydratase operon activator protein (VIMSS) compare
b1620 malI +0.4 1.1 DNA-binding transcriptional repressor (NCBI) compare
b2804 fucU +0.4 1.0 L-fucose mutarotase (NCBI) compare
b1959 yedA +0.4 1.6 predicted inner membrane protein (NCBI) compare
b2708 gutQ +0.4 1.7 orf, hypothetical protein (VIMSS) compare
b1553 ydfP +0.4 1.2 Qin prophage; conserved protein (NCBI) compare
b4613 dinQ +0.4 0.8 Damage inducible, function unknown (RefSeq) compare
b4533 ynfO +0.4 1.0 Qin prophage; predicted protein (NCBI) compare
b0247 ykfG +0.4 0.7 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b1295 ymjA +0.4 0.9 hypothetical protein (NCBI) compare
b2814 metZ +0.4 0.8 tRNA-Met (NCBI) compare
b1282 yciH +0.4 2.0 orf, hypothetical protein (VIMSS) compare
b2916 argP +0.4 2.2 chromosome replication initiation inhibitor protein (NCBI) compare
b1384 feaR +0.4 2.6 DNA-binding transcriptional dual regulator (NCBI) compare
b1559 b1559 +0.4 2.3 orf, hypothetical protein (VIMSS) compare
b1821 b1821 +0.4 1.6 orf, hypothetical protein (VIMSS) compare
b0864 artP +0.4 1.6 arginine transporter subunit (NCBI) compare
b2209 eco +0.4 0.7 ecotin precursor (NCBI) compare
b1478 adhP +0.4 1.6 alcohol dehydrogenase (VIMSS) compare
b3002 yqhA +0.4 0.7 hypothetical protein (NCBI) compare
b3228 sspB +0.4 1.7 ClpXP protease specificity-enhancing factor (NCBI) compare
b3221 yhcH +0.4 2.0 hypothetical protein (NCBI) compare
b1949 fliQ +0.4 1.1 flagellar biosynthesis protein Q (NCBI) compare
b4552 yrhC +0.4 0.4 no description compare
b2859 ygeO +0.4 0.8 hypothetical protein (RefSeq) compare
b0775 bioB +0.4 2.1 biotin synthase (NCBI) compare
b2792 yqcC +0.4 1.4 hypothetical protein (NCBI) compare
b4246 pyrL +0.4 0.8 pyrBI operon leader peptide (NCBI) compare
b1008 ycdI +0.4 1.7 hypothetical protein (NCBI) compare
b0906 ycaP +0.4 2.3 conserved inner membrane protein (NCBI) compare
b4460 araH +0.4 1.0 fused L-arabinose transporter subunits of ABC superfamily: membrane components (RefSeq) compare
b1222 narX +0.4 1.7 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b1839 yebY +0.4 1.3 hypothetical protein (NCBI) compare
b0613 citG +0.4 1.7 triphosphoribosyl-dephospho-CoA transferase (NCBI) compare
b1777 b1777 +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b2198 ccmD +0.4 1.3 cytochrome c biogenesis protein (NCBI) compare
b0340 cynS +0.4 1.4 cyanate hydratase (NCBI) compare
b1684 sufA +0.4 0.8 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b0210 yafE +0.4 1.2 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b1608 rstA +0.4 1.6 DNA-binding response regulator in two-component regulatory system with RstB (RefSeq) compare
b2134 pbpG +0.4 2.3 penicillin-binding protein 7 (VIMSS) compare
b1853 yebK +0.4 0.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b2668 ygaP +0.4 2.0 predicted inner membrane protein with hydrolase activity (NCBI) compare
b0388 aroL +0.4 1.5 shikimate kinase II (NCBI) compare
b0495 ybbA +0.4 1.6 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b2049 cpsB +0.4 1.5 mannose-1-phosphate guanyltransferase (NCBI) compare
b2918 argK +0.4 1.7 arginine/ornithine transport system ATPase (NCBI) compare
b0785 moaE +0.4 1.6 molybdopterin synthase, large subunit (NCBI) compare
b0604 dsbG +0.4 2.1 thiol:disulfide interchange protein (VIMSS) compare
b2443 yffL +0.4 2.0 CPZ-55 prophage; predicted protein (NCBI) compare
b0505 allA +0.4 1.2 ureidoglycolate hydrolase (NCBI) compare
b2666 yqaE +0.4 1.8 predicted membrane protein (NCBI) compare
b0682 ybfN +0.4 1.6 predicted lipoprotein (NCBI) compare
b1072 flgA +0.4 1.5 flagellar basal body P-ring biosynthesis protein A (NCBI) compare
b1859 znuB +0.4 2.2 high-affinity zinc transporter membrane component (NCBI) compare
b4685 yrbN +0.4 0.8 expressed protein (RefSeq) compare
b2301 yfcF +0.4 1.7 predicted enzyme (NCBI) compare
b1234 rssA +0.4 1.6 conserved protein (RefSeq) compare
b0776 bioF +0.4 2.2 8-amino-7-oxononanoate synthase (NCBI) compare
b1962 yedJ +0.4 1.9 predicted phosphohydrolase (NCBI) compare
b4104 phnE +0.4 1.4 phosphonate/organophosphate ester transporter subunit (NCBI) compare
b0556 rzpD +0.4 1.2 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b1837 yebW +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b1789 yeaL +0.4 1.4 conserved inner membrane protein (NCBI) compare
b1048 mdoG +0.4 1.7 glucan biosynthesis protein, periplasmic (NCBI) compare
b4152 frdC +0.4 0.9 fumarate reductase subunit C (NCBI) compare
b1475 fdnH +0.4 1.5 formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible (NCBI) compare
b0109 nadC +0.3 2.0 nicotinate-nucleotide pyrophosphorylase (NCBI) compare
b0934 ycbM +0.3 0.7 putative transport system permease protein (VIMSS) compare
b2634 yfjR +0.3 1.5 CP4-57 prophage; predicted DNA-binding transcriptional regulator (NCBI) compare
b2114 metG +0.3 0.9 methionyl-tRNA synthetase (NCBI) compare
b1412 azoR +0.3 1.1 acyl carrier protein phosphodiesterase (NCBI) compare
b0802 ybiJ +0.3 0.8 hypothetical protein (NCBI) compare
b1296 ycjJ +0.3 1.2 putative amino acid/amine transport protein (VIMSS) compare
b2303 folX +0.3 2.1 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase (NCBI) compare
b4519 icdC +0.3 1.3 no description compare
b2061 wzb +0.3 0.8 protein-tyrosine phosphatase (NCBI) compare
b4614 sokA +0.3 1.0 no description compare
b2846 yqeH +0.3 0.2 orf, hypothetical protein (VIMSS) compare
b2221 atoD +0.3 1.3 acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (NCBI) compare
b0849 grxA +0.3 1.1 glutaredoxin 1, redox coenzyme for ribonucleotide reductase (RNR1a) (NCBI) compare
b1729 ydjN +0.3 1.4 predicted transporter (NCBI) compare
b1520 b1520 +0.3 1.0 orf, hypothetical protein (VIMSS) compare
b2913 serA +0.3 2.0 D-3-phosphoglycerate dehydrogenase (NCBI) compare
b1372 b1372 +0.3 1.8 putative membrane protein (VIMSS) compare
b4041 plsB +0.3 0.9 glycerol-3-phosphate acyltransferase (VIMSS) compare
b2142 yohK +0.3 2.0 predicted inner membrane protein (NCBI) compare
b2587 kgtP +0.3 2.0 alpha-ketoglutarate transporter (NCBI) compare
b4642 yoeD +0.3 1.1 no description compare
b1104 ycfL +0.3 0.7 hypothetical protein (NCBI) compare
b1806 yeaY +0.3 1.1 predicted lipoprotein (NCBI) compare
b0523 purE +0.3 1.2 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b4148 sugE +0.3 1.6 suppresses groEL, may be chaperone (VIMSS) compare
b3098 yqjD +0.3 1.3 hypothetical protein (NCBI) compare
b1539 ydfG +0.3 1.2 L-allo-threonine dehydrogenase, NAD(P)-binding (NCBI) compare
b2700 ygaD +0.3 1.4 competence damage-inducible protein A (NCBI) compare
b1213 ychQ +0.3 1.2 predicted transcriptional regulator (NCBI) compare
b4651 yibW +0.3 0.2 no description compare
b0061 araD +0.3 1.9 L-ribulose-5-phosphate 4-epimerase (NCBI) compare
b4589 ylcI +0.3 1.0 hypothetical protein (RefSeq) compare
b3449 ugpQ +0.3 1.5 cytoplasmic glycerophosphodiester phosphodiesterase (NCBI) compare
b1920 fliY +0.3 0.8 cystine transporter subunit (NCBI) compare
b1577 ydfE +0.3 1.7 Qin prophage; predicted protein (RefSeq) compare
b1279 yciS +0.3 0.5 conserved inner membrane protein (NCBI) compare
b0385 yaiC +0.3 1.8 predicted diguanylate cyclase (NCBI) compare
b0902 pflA +0.3 1.9 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b2319 usg +0.3 1.5 hypothetical protein (NCBI) compare
b4656 yjhY +0.3 1.1 no description compare
b3010 yqhC +0.3 1.5 putative ARAC-type regulatory protein (VIMSS) compare
b1565 ydfV +0.3 1.2 Qin prophage; predicted protein (NCBI) compare
b1656 sodB +0.3 1.0 superoxide dismutase, Fe (NCBI) compare
b0994 torT +0.3 1.4 periplasmic sensory protein associated with the TorRS two-component regulatory system (NCBI) compare
b4349 hsdM +0.3 2.3 DNA methylase M (NCBI) compare
b2093 gatB +0.3 1.3 galactitol-specific enzyme IIB component of PTS (NCBI) compare
b1727 yniC +0.3 0.7 predicted hydrolase (NCBI) compare
b2170 setB +0.3 1.5 lactose/glucose efflux system (NCBI) compare
b2541 hcaB +0.3 1.4 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase (NCBI) compare
b1096 pabC +0.3 1.7 4-amino-4-deoxychorismate lyase (NCBI) compare
b4547 ypfN +0.3 1.3 hypothetical protein (NCBI) compare
b1205 ychH +0.3 0.5 predicted inner membrane protein (NCBI) compare
b3164 pnp +0.3 0.8 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b0336 codB +0.3 1.8 cytosine transporter (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress Sulfamonomethoxine across organisms