Experiment set10IT037 for Escherichia coli BW25113

Compare to:

LB Aerobic with Sulfamonomethoxine 0.00025 mM

200 most important genes:

  gene name fitness t score description  
b0920 ycbC -6.2 -4.3 conserved inner membrane protein (NCBI) compare
b1865 nudB -3.6 -2.4 dATP pyrophosphohydrolase (NCBI) compare
b2259 pmrD -3.1 -1.7 polymyxin resistance protein B (VIMSS) compare
b3636 rpmG -3.0 -2.9 50S ribosomal protein L33 (NCBI) compare
b3341 rpsG -2.7 -1.8 30S ribosomal protein S7 (NCBI) compare
b1830 prc -2.7 -4.5 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b0053 surA -2.7 -4.4 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1429 tehA -2.5 -1.6 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b2642 yfjW -2.5 -1.6 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b0145 dksA -2.5 -2.9 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b0149 mrcB -2.2 -12.7 penicillin-binding protein 1b (NCBI) compare
b0990 cspG -2.2 -2.0 DNA-binding transcriptional regulator (NCBI) compare
b2433 b2433 -2.1 -3.1 orf, hypothetical protein (VIMSS) compare
b1252 tonB -2.1 -3.4 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b0630 lipB -2.1 -1.4 protein of lipoate biosynthesis (VIMSS) compare
b0739 tolA -2.0 -2.3 cell envelope integrity inner membrane protein TolA (NCBI) compare
b4655 ythA -2.0 -1.5 expressed protein (RefSeq) compare
b0564 appY -2.0 -1.3 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b2363 yfdT -1.9 -2.8 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b2620 smpB -1.9 -1.8 SsrA-binding protein (NCBI) compare
b1863 ruvC -1.9 -1.8 Holliday junction resolvase (NCBI) compare
b2531 iscR -1.9 -1.7 DNA-binding transcriptional repressor (NCBI) compare
b2830 nudH -1.9 -1.2 dinucleoside polyphosphate hydrolase (NCBI) compare
b4171 miaA -1.8 -3.0 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b3390 aroK -1.8 -2.2 shikimate kinase I (NCBI) compare
b2518 ndk -1.8 -2.5 nucleoside diphosphate kinase (NCBI) compare
b4042 dgkA -1.6 -1.9 diacylglycerol kinase (NCBI) compare
b0730 mngR -1.6 -1.8 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b3163 nlpI -1.6 -4.3 hypothetical protein (NCBI) compare
b0092 ddlB -1.6 -5.4 D-alanylalanine synthetase (NCBI) compare
b0049 apaH -1.5 -2.7 diadenosinetetraphosphatase (NCBI) compare
b0726 sucA -1.5 -3.6 alpha-ketoglutarate decarboxylase (NCBI) compare
b3621 rfaC -1.5 -4.3 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b4520 ymgF -1.5 -1.6 hypothetical protein (NCBI) compare
b0852 rimK -1.4 -3.0 ribosomal protein S6 modification protein (NCBI) compare
b1696 ydiP -1.4 -1.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b3764 yifE -1.4 -3.5 hypothetical protein (NCBI) compare
b4418 sraB -1.4 -2.0 unknown RNA (NCBI) compare
b3844 fre -1.4 -5.0 NAD(P)H-flavin reductase (NCBI) compare
b3620 rfaF -1.4 -4.6 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b0740 tolB -1.3 -3.3 translocation protein TolB precursor (NCBI) compare
b1370 insH-5 -1.3 -2.4 Rac prophage; IS5 transposase and trans-activator (NCBI) compare
b2912 ygfA -1.3 -2.9 putative ligase (VIMSS) compare
b4503 yafF -1.3 -0.8 no description compare
b3916 pfkA -1.2 -1.7 6-phosphofructokinase (NCBI) compare
b2567 rnc -1.2 -0.8 ribonuclease III (NCBI) compare
b1765 ydjA -1.2 -1.1 predicted oxidoreductase (NCBI) compare
b0937 ssuE -1.2 -2.3 NAD(P)H-dependent FMN reductase (NCBI) compare
b2085 b2085 -1.2 -2.5 orf, hypothetical protein (VIMSS) compare
b2744 surE -1.2 -4.9 acid phosphatase (NCBI) compare
b0617 citD -1.2 -2.1 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b0627 tatE -1.2 -2.3 twin arginine translocase protein E (NCBI) compare
b0858 ybjO -1.2 -1.9 predicted inner membrane protein (NCBI) compare
b1238 tdk -1.2 -3.2 thymidine kinase (NCBI) compare
b3778 rep -1.2 -4.7 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1847 yebF -1.2 -1.7 predicted protein (RefSeq) compare
b0729 sucD -1.2 -2.1 succinyl-CoA synthetase subunit alpha (NCBI) compare
b1677 lpp -1.1 -1.8 murein lipoprotein (NCBI) compare
b1575 dicB -1.1 -1.3 Qin prophage; cell division inhibition protein (NCBI) compare
b1332 ynaJ -1.1 -0.7 predicted inner membrane protein (NCBI) compare
b2083 yegZ -1.1 -2.1 orf, hypothetical protein (VIMSS) compare
b0232 yafN -1.1 -0.7 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1711 btuC -1.1 -3.4 vtamin B12-transporter permease (NCBI) compare
b4676 yoaK -1.1 -0.7 expressed protein (RefSeq) compare
b3870 glnA -1.1 -1.9 glutamine synthetase (NCBI) compare
b1530 marR -1.1 -3.4 multiple antibiotic resistance protein; repressor of mar operon (VIMSS) compare
b1361 ydaW -1.1 -0.8 orf, hypothetical protein (VIMSS) compare
b2820 recB -1.1 -0.7 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b4480 hdfR -1.1 -4.2 transcriptional regulator HdfR (NCBI) compare
b3977 tyrU -1.1 -0.8 tRNA-Tyr (NCBI) compare
b4644 ypjI -1.1 -3.5 no description compare
b2376 ypdI -1.1 -2.1 predicted lipoprotein involved in colanic acid biosynthesis (NCBI) compare
b3169 nusA -1.0 -2.2 transcription elongation factor NusA (NCBI) compare
b1527 yneK -1.0 -1.4 hypothetical protein (NCBI) compare
b4509 ylcG -1.0 -2.3 DLP12 prophage; predicted protein (NCBI) compare
b2017 yefM -1.0 -1.2 orf, hypothetical protein (VIMSS) compare
b2189 proL -1.0 -1.7 tRNA-Pro (NCBI) compare
b2904 gcvH -1.0 -1.8 glycine cleavage system protein H (NCBI) compare
b0683 fur -1.0 -1.3 ferric uptake regulator (NCBI) compare
b4239 treC -1.0 -1.0 trehalose-6-P hydrolase (NCBI) compare
b3629 rfaS -1.0 -1.7 lipopolysaccharide core biosynthesis protein (NCBI) compare
b3619 rfaD -1.0 -2.5 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b4535 yniD -1.0 -1.1 predicted protein (RefSeq) compare
b2318 truA -1.0 -2.3 tRNA pseudouridine synthase A (NCBI) compare
b3962 udhA -1.0 -4.1 putative oxidoreductase (VIMSS) compare
b4436 ryeC -1.0 -1.3 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b1107 nagZ -1.0 -2.7 beta-hexosaminidase (NCBI) compare
b1824 yobF -1.0 -1.4 hypothetical protein (NCBI) compare
b0015 dnaJ -1.0 -5.5 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b4242 mgtA -1.0 -5.5 magnesium transporter (NCBI) compare
b1346 ydaQ -1.0 -1.1 orf, hypothetical protein (VIMSS) compare
b1861 ruvA -1.0 -0.8 Holliday junction DNA helicase motor protein (NCBI) compare
b2330 yfcB -1.0 -1.2 putative adenine-specific methylase (VIMSS) compare
b1648 b1648 -1.0 -1.4 orf, hypothetical protein (VIMSS) compare
b1730 ydjO -1.0 -0.6 predicted protein (RefSeq) compare
b4679 yohP -0.9 -2.0 expressed protein (RefSeq) compare
b0125 hpt -0.9 -3.3 hypoxanthine phosphoribosyltransferase (VIMSS) compare
b3966 btuB -0.9 -7.1 vitamin B12/cobalamin outer membrane transporter (NCBI) compare
b1334 fnr -0.9 -1.8 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b3443 yrhA -0.9 -1.2 orf, hypothetical protein (VIMSS) compare
b3205 yhbJ -0.9 -2.6 hypothetical protein (NCBI) compare
b1579 intQ -0.9 -0.6 Qin prophage; predicted defective integrase (RefSeq) compare
b3026 qseC -0.9 -1.7 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b0957 ompA -0.9 -2.1 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b3052 rfaE -0.9 -3.0 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b4045 yjbJ -0.9 -1.3 predicted stress response protein (NCBI) compare
b4019 metH -0.9 -7.0 B12-dependent methionine synthase (NCBI) compare
b2038 rfbC -0.9 -4.2 dTDP-4-deoxyrhamnose-3,5-epimerase (NCBI) compare
b1620 malI -0.9 -1.7 DNA-binding transcriptional repressor (NCBI) compare
b2498 upp -0.9 -1.6 uracil phosphoribosyltransferase (VIMSS) compare
b0737 tolQ -0.9 -1.5 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3183 obgE -0.9 -0.8 GTPase involved in cell partioning and DNA repair (NCBI) compare
b1758 b1758 -0.9 -1.1 putative cytochrome oxidase (VIMSS) compare
b2586 yfiM -0.9 -2.6 predicted protein (RefSeq) compare
b3414 gntY -0.9 -3.2 predicted gluconate transport associated protein (NCBI) compare
b4416 rybA -0.8 -1.2 unknown RNA (NCBI) compare
b3858 yihD -0.8 -1.9 hypothetical protein (NCBI) compare
b1205 ychH -0.8 -1.7 predicted inner membrane protein (NCBI) compare
b0088 murD -0.8 -1.5 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b1950 fliR -0.8 -1.5 flagellar biosynthesis protein R (NCBI) compare
b3630 rfaP -0.8 -4.5 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b4177 purA -0.8 -0.9 adenylosuccinate synthetase (NCBI) compare
b3631 rfaG -0.8 -5.9 glucosyltransferase I (NCBI) compare
b4146 yjeK -0.8 -0.9 predicted lysine aminomutase (NCBI) compare
b4202 rpsR -0.8 -0.7 30S ribosomal protein S18 (NCBI) compare
b3405 ompR -0.8 -2.8 osmolarity response regulator (NCBI) compare
b1185 dsbB -0.8 -1.8 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b0143 pcnB -0.8 -3.2 poly(A) polymerase I (VIMSS) compare
b2165 yeiN -0.8 -2.9 hypothetical protein (NCBI) compare
b3842 rfaH -0.8 -3.2 transcriptional activator RfaH (NCBI) compare
b1874 cutC -0.8 -1.7 copper homeostasis protein (NCBI) compare
b2512 yfgL -0.8 -3.1 protein assembly complex, lipoprotein component (NCBI) compare
b2175 spr -0.8 -2.3 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b4631 ykgQ -0.8 -0.9 no description compare
b3199 yrbK -0.8 -1.5 hypothetical protein (NCBI) compare
b2894 xerD -0.8 -0.7 site-specific tyrosine recombinase XerD (NCBI) compare
b1961 dcm -0.8 -1.4 DNA cytosine methylase (NCBI) compare
b1344 ydaO -0.8 -1.3 predicted C32 tRNA thiolase (NCBI) compare
b0890 ftsK -0.8 -1.2 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b2003 yeeT -0.8 -2.5 CP4-44 prophage; predicted protein (NCBI) compare
b4191 ulaR -0.7 -1.9 DNA-binding transcriptional dual regulator (NCBI) compare
b3119 tdcR -0.7 -1.5 threonine dehydratase operon activator protein (VIMSS) compare
b3644 yicC -0.7 -3.2 hypothetical protein (NCBI) compare
b3811 xerC -0.7 -0.7 site-specific tyrosine recombinase XerC (NCBI) compare
b1831 proQ -0.7 -2.5 putative solute/DNA competence effector (NCBI) compare
b2808 gcvA -0.7 -1.9 DNA-binding transcriptional dual regulator (NCBI) compare
b4613 dinQ -0.7 -1.2 Damage inducible, function unknown (RefSeq) compare
b0438 clpX -0.7 -3.2 ATP-dependent protease ATP-binding subunit (NCBI) compare
b3261 fis -0.7 -0.8 DNA-binding protein Fis (NCBI) compare
b3469 zntA -0.7 -3.6 zinc, cobalt and lead efflux system (NCBI) compare
b1536 ydeI -0.7 -0.5 hypothetical protein (NCBI) compare
b0456 ybaA -0.7 -2.1 hypothetical protein (NCBI) compare
b4640 yoeG -0.7 -1.1 no description compare
b2366 dsdA -0.7 -2.5 D-serine dehydratase (NCBI) compare
b1877 yecT -0.7 -0.8 orf, hypothetical protein (VIMSS) compare
b4701 sokX -0.7 -0.8 sok-related sRNA, function unknown (RefSeq) compare
b0688 pgm -0.7 -1.7 phosphoglucomutase (NCBI) compare
b1192 ldcA -0.7 -2.6 L,D-carboxypeptidase A (NCBI) compare
b1659 ydhB -0.7 -1.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b4201 priB -0.7 -1.5 primosomal replication protein N (NCBI) compare
b1905 ftn -0.7 -3.9 ferritin iron storage protein (cytoplasmic) (NCBI) compare
b1614 ydgA -0.7 -2.3 hypothetical protein (NCBI) compare
b1159 mcrA -0.7 -0.4 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b2935 tktA -0.7 -0.9 transketolase 1, thiamin-binding (NCBI) compare
b1480 sra -0.7 -0.8 30S ribosomal subunit protein S22 (NCBI) compare
b3839 tatC -0.7 -3.3 TatABCE protein translocation system subunit (NCBI) compare
b1286 rnb -0.7 -1.2 exoribonuclease II (NCBI) compare
b0218 yafU -0.7 -1.1 predicted inner membrane protein (RefSeq) compare
b3236 mdh -0.7 -3.3 malate dehydrogenase (NCBI) compare
b1368 ynaA -0.7 -1.2 Rac prophage; predicted tail protein (RefSeq) compare
b1175 minD -0.7 -2.3 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b1550 b1550 -0.7 -0.8 orf, hypothetical protein (VIMSS) compare
b0141 yadN -0.6 -2.8 predicted fimbrial-like adhesin protein (NCBI) compare
b3613 yibP -0.6 -1.2 putative membrane protein (VIMSS) compare
b2624 alpA -0.6 -3.1 CP4-57 prophage; DNA-binding transcriptional activator (NCBI) compare
b0463 acrA -0.6 -4.3 multidrug efflux system (NCBI) compare
b3627 rfaI -0.6 -3.6 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b1671 ydhX -0.6 -1.4 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b2393 nupC -0.6 -3.2 nucleoside (except guanosine) transporter (NCBI) compare
b2638 yfjU -0.6 -2.6 CP4-57 prophage; conserved protein (RefSeq) compare
b0723 sdhA -0.6 -4.3 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b0724 sdhB -0.6 -2.6 succinate dehydrogenase, FeS subunit (NCBI) compare
b2291 yfbR -0.6 -1.5 hypothetical protein (NCBI) compare
b4618 tisB -0.6 -2.2 lexA-regulated toxic peptide (RefSeq) compare
b1261 trpB -0.6 -1.6 tryptophan synthase subunit beta (NCBI) compare
b1753 ynjA -0.6 -1.6 hypothetical protein (NCBI) compare
b2903 gcvP -0.6 -4.3 glycine dehydrogenase (NCBI) compare
b2506 yfgI -0.6 -1.3 hypothetical protein (NCBI) compare
b2951 yggS -0.6 -2.2 predicted enzyme (NCBI) compare
b4552 yrhC -0.6 -0.4 no description compare
b2413 cysZ -0.6 -2.9 putative sulfate transport protein CysZ (NCBI) compare
b0706 ybfD -0.6 -0.9 hypothetical protein (NCBI) compare
b0660 ybeZ -0.6 -2.5 predicted protein with nucleoside triphosphate hydrolase domain (RefSeq) compare
b1220 ychO -0.6 -2.4 predicted invasin (RefSeq) compare
b2699 recA -0.6 -0.6 recombinase A (NCBI) compare
b2579 yfiD -0.6 -1.1 pyruvate formate lyase subunit (NCBI) compare
b4590 ybfK -0.6 -0.4 hypothetical protein (RefSeq) compare
b1292 sapC -0.6 -0.8 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0300 ykgA -0.6 -1.2 putative ARAC-type regulatory protein (VIMSS) compare
b1951 rcsA -0.6 -0.7 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare


Specific Phenotypes

For 1 genes in this experiment

For stress Sulfamonomethoxine in Escherichia coli BW25113

For stress Sulfamonomethoxine across organisms