Experiment set10IT037 for Escherichia coli BW25113

Compare to:

LB Aerobic with Sulfamonomethoxine 0.00025 mM

200 most detrimental genes:

  gene name fitness t score description  
b1606 folM +1.3 8.8 short chain dehydrogenase (NCBI) compare
b2684 mprA +1.3 5.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b1217 chaB +1.2 1.9 cation transport regulator (NCBI) compare
b1920 fliY +1.1 3.2 cystine transporter subunit (NCBI) compare
b4589 ylcI +1.0 2.2 hypothetical protein (RefSeq) compare
b1563 relE +1.0 1.6 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b3500 gor +1.0 1.9 glutathione reductase (NCBI) compare
b0784 moaD +0.9 2.0 molybdopterin synthase, small subunit (NCBI) compare
b2303 folX +0.9 6.4 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase (NCBI) compare
b1427 rimL +0.9 2.9 ribosomal-protein-L7/L12-serine acetyltransferase (NCBI) compare
b1279 yciS +0.9 1.4 conserved inner membrane protein (NCBI) compare
b2597 yfiA +0.9 2.3 cold shock protein associated with 30S ribosomal subunit (NCBI) compare
b1827 kdgR +0.8 2.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b2209 eco +0.8 2.4 ecotin precursor (NCBI) compare
b0881 clpS +0.8 2.2 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b4246 pyrL +0.8 2.4 pyrBI operon leader peptide (NCBI) compare
b2279 nuoK +0.8 1.4 NADH dehydrogenase subunit K (NCBI) compare
b4603 rseX +0.8 0.9 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b1818 manY +0.7 1.9 mannose-specific enzyme IIC component of PTS (NCBI) compare
b4647 mokA +0.7 0.4 no description compare
b1684 sufA +0.7 1.8 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b0247 ykfG +0.7 1.3 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b1143 ymfI +0.7 0.8 orf, hypothetical protein (VIMSS) compare
b1572 ydfB +0.7 1.6 orf, hypothetical protein (VIMSS) compare
b3761 trpT +0.7 1.5 tRNA-Trp (NCBI) compare
b2450 yffS +0.7 1.7 CPZ-55 prophage; predicted protein (RefSeq) compare
b2768 ygcP +0.7 2.1 predicted anti-terminator regulatory protein (NCBI) compare
b3649 rpoZ +0.7 1.9 DNA-directed RNA polymerase subunit omega (NCBI) compare
b2195 ccmG +0.7 2.0 periplasmic thioredoxin of cytochrome c-type biogenesis (NCBI) compare
b1337 abgB +0.7 2.6 predicted peptidase, aminobenzoyl-glutamate utilization protein (NCBI) compare
b1382 ynbE +0.6 1.4 predicted lipoprotein (NCBI) compare
b1959 yedA +0.6 2.6 predicted inner membrane protein (NCBI) compare
b1251 yciI +0.6 2.2 orf, hypothetical protein (VIMSS) compare
b1434 ydcN +0.6 1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b1811 yoaH +0.6 1.3 hypothetical protein (NCBI) compare
b1120 cobB +0.6 2.5 deacetylase of acs and cheY, regulates chemotaxis (NCBI) compare
b1630 rsxD +0.6 3.2 electron transport complex protein RnfD (NCBI) compare
b2058 wcaB +0.6 0.9 predicted acyl transferase (NCBI) compare
b1627 rsxA +0.6 2.2 Na(+)-translocating NADH-quinone reductase subunit E (NCBI) compare
b2419 yfeK +0.6 1.3 hypothetical protein (NCBI) compare
b1848 yebG +0.6 1.2 conserved protein regulated by LexA (NCBI) compare
b1194 ycgR +0.6 1.7 protein involved in flagellar function (NCBI) compare
b2990 hybG +0.6 1.8 hydrogenase 2 accessory protein (NCBI) compare
b1583 ynfB +0.6 1.8 hypothetical protein (NCBI) compare
b2708 gutQ +0.6 2.7 orf, hypothetical protein (VIMSS) compare
b1582 ynfA +0.6 1.4 hypothetical protein (NCBI) compare
b2993 hybD +0.6 2.8 predicted maturation element for hydrogenase 2 (NCBI) compare
b2421 cysM +0.6 1.7 cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) compare
b2198 ccmD +0.6 2.0 cytochrome c biogenesis protein (NCBI) compare
b3152 yraR +0.6 2.8 orf, hypothetical protein (VIMSS) compare
b1841 yobA +0.6 1.1 hypothetical protein (NCBI) compare
b3366 nirD +0.6 2.8 nitrite reductase small subunit (NCBI) compare
b4402 yjjY +0.6 0.5 hypothetical protein (NCBI) compare
b3836 b3836 +0.6 1.9 orf, hypothetical protein (VIMSS) compare
b0979 appB +0.5 2.4 cytochrome bd-II oxidase, subunit II (NCBI) compare
b1151 ymfO +0.5 2.0 e14 prophage; conserved protein (RefSeq) compare
b3238 yhcN +0.5 1.4 orf, hypothetical protein (VIMSS) compare
b1921 fliZ +0.5 1.3 orf, hypothetical protein (VIMSS) compare
b2143 cdd +0.5 2.3 cytidine deaminase (NCBI) compare
b4373 rimI +0.5 1.8 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b0195 yaeB +0.5 2.8 hypothetical protein (NCBI) compare
b1821 b1821 +0.5 1.9 orf, hypothetical protein (VIMSS) compare
b0450 glnK +0.5 1.5 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) compare
b1782 mipA +0.5 2.3 scaffolding protein for murein synthesizing machinery (NCBI) compare
b1317 ycjU +0.5 1.6 predicted beta-phosphoglucomutase (NCBI) compare
b2804 fucU +0.5 1.6 L-fucose mutarotase (NCBI) compare
b1380 ldhA +0.5 1.3 D-lactate dehydrogenase (NCBI) compare
b1150 ymfR +0.5 0.7 e14 prophage; predicted protein (NCBI) compare
b1993 cobU +0.5 3.0 adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase (NCBI) compare
b1960 vsr +0.5 1.9 DNA mismatch endonuclease of very short patch repair (NCBI) compare
b1618 uidR +0.5 1.8 DNA-binding transcriptional repressor (NCBI) compare
b2443 yffL +0.5 2.0 CPZ-55 prophage; predicted protein (NCBI) compare
b2258 b2258 +0.5 0.9 putative transport/receptor protein (VIMSS) compare
b1613 manA +0.5 0.8 mannose-6-phosphate isomerase (VIMSS) compare
b1557 cspB +0.5 1.0 Qin prophage; cold shock protein (NCBI) compare
b2111 yehD +0.5 1.4 predicted fimbrial-like adhesin protein (NCBI) compare
b1109 ndh +0.5 1.5 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b1819 manZ +0.5 1.9 mannose-specific enzyme IID component of PTS (NCBI) compare
b1431 ydcL +0.5 1.9 predicted lipoprotein (NCBI) compare
b1199 dhaL +0.5 1.5 dihydroxyacetone kinase, C-terminal domain (NCBI) compare
b1992 cobS +0.5 0.8 cobalamin synthase (NCBI) compare
b1846 yebE +0.5 2.0 hypothetical protein (NCBI) compare
b2703 srlE +0.5 2.5 glucitol/sorbitol-specific enzyme IIB component of PTS (NCBI) compare
b1622 malY +0.5 2.1 bifunctional beta-cystathionase, PLP-dependent/ regulator of maltose regulon (NCBI) compare
b1609 rstB +0.5 1.5 sensory histidine kinase in two-component regulatory system with RstA (NCBI) compare
b1263 trpD +0.5 1.3 bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) compare
b1745 astB +0.5 2.5 succinylarginine dihydrolase (NCBI) compare
b0464 acrR +0.5 3.6 DNA-binding transcriptional repressor (NCBI) compare
b1712 ihfA +0.5 0.6 integration host factor subunit alpha (NCBI) compare
b0912 ihfB +0.5 1.6 integration host factor subunit beta (NCBI) compare
b0389 yaiA +0.5 1.3 hypothetical protein (NCBI) compare
b1803 yeaX +0.5 1.8 predicted oxidoreductase (NCBI) compare
b1667 ydhR +0.4 0.7 hypothetical protein (NCBI) compare
b2923 argO +0.4 2.5 arginine exporter protein (NCBI) compare
b1379 hslJ +0.4 1.8 heat-inducible protein (NCBI) compare
b1764 selD +0.4 1.7 selenophosphate synthetase (NCBI) compare
b1469 narU +0.4 2.1 nitrate/nitrite transporter (NCBI) compare
b1632 rsxE +0.4 2.8 NADH-ubiquinone oxidoreductase (NCBI) compare
b1953 b1953 +0.4 1.4 orf, hypothetical protein (VIMSS) compare
b2485 hyfE +0.4 2.1 hydrogenase 4, membrane subunit (NCBI) compare
b1647 ydhF +0.4 1.3 predicted oxidoreductase (NCBI) compare
b2832 ygdQ +0.4 2.7 predicted inner membrane protein (NCBI) compare
b1266 yciV +0.4 1.5 hypothetical protein (NCBI) compare
b1971 yedY +0.4 1.8 hypothetical protein (NCBI) compare
b0678 nagB +0.4 2.0 glucosamine-6-phosphate deaminase (NCBI) compare
b1751 ydjY +0.4 1.8 orf, hypothetical protein (VIMSS) compare
b0843 ybjH +0.4 1.2 hypothetical protein (NCBI) compare
b0685 ybfE +0.4 1.0 orf, hypothetical protein (VIMSS) compare
b3973 birA +0.4 1.1 biotin--protein ligase (NCBI) compare
b0903 pflB +0.4 3.2 pyruvate formate lyase I (NCBI) compare
b1977 asnT +0.4 1.4 tRNA-Asn (NCBI) compare
b1808 yoaA +0.4 2.5 conserved protein with nucleoside triphosphate hydrolase domain (NCBI) compare
b0613 citG +0.4 1.7 triphosphoribosyl-dephospho-CoA transferase (NCBI) compare
b1264 trpE +0.4 2.3 anthranilate synthase component I (NCBI) compare
b1521 uxaB +0.4 2.4 tagaturonate reductase (NCBI) compare
b1608 rstA +0.4 1.7 DNA-binding response regulator in two-component regulatory system with RstB (RefSeq) compare
b2050 wcaI +0.4 1.5 predicted glycosyl transferase (NCBI) compare
b1438 ydcQ +0.4 1.5 predicted DNA-binding transcriptional regulator (RefSeq) compare
b4386 lplA +0.4 2.7 lipoate-protein ligase A (NCBI) compare
b2510 b2510 +0.4 1.7 orf, hypothetical protein (VIMSS) compare
b4695 ykgT +0.4 0.9 no description compare
b1625 ydgT +0.4 2.2 predicted regulator (NCBI) compare
b3611 yibN +0.4 1.8 predicted rhodanese-related sulfurtransferase (NCBI) compare
b2313 cvpA +0.4 1.7 membrane protein required for colicin V production (NCBI) compare
b4546 ypeB +0.4 0.7 hypothetical protein (NCBI) compare
b1421 trg +0.4 2.1 methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor (NCBI) compare
b1396 paaI +0.4 1.7 predicted thioesterase (NCBI) compare
b4435 isrC +0.4 1.0 unknown RNA (NCBI) compare
b1306 pspC +0.4 1.0 DNA-binding transcriptional activator (NCBI) compare
b2074 b2074 +0.4 1.6 putative membrane protein (VIMSS) compare
b4568 ytjA +0.4 1.1 predicted protein (RefSeq) compare
b2673 nrdH +0.4 1.3 glutaredoxin-like protein (NCBI) compare
b1269 rluB +0.4 1.0 23S rRNA pseudouridylate synthase (NCBI) compare
b1859 znuB +0.4 2.1 high-affinity zinc transporter membrane component (NCBI) compare
b1294 sapA +0.4 2.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0131 panD +0.4 1.4 aspartate 1-decarboxylase precursor (NCBI) compare
b3204 ptsN +0.4 1.8 sugar-specific enzyme IIA component of PTS (NCBI) compare
b1336 ydaH +0.4 1.4 putative pump protein (transport) (VIMSS) compare
b1034 ycdX +0.4 1.7 hypothetical protein (NCBI) compare
b2427 yfeT +0.4 2.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b1686 ydiI +0.4 0.8 hypothetical protein (NCBI) compare
b1222 narX +0.4 1.4 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b3198 kdsC +0.4 1.5 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b2426 ucpA +0.4 0.8 putative oxidoreductase (VIMSS) compare
b1360 ydaV +0.4 1.4 Rac prophage; predicted DNA replication protein (NCBI) compare
b0249 ykfF +0.4 0.8 CP4-6 prophage; predicted protein (NCBI) compare
b1048 mdoG +0.4 1.9 glucan biosynthesis protein, periplasmic (NCBI) compare
b1518 lsrG +0.4 0.9 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b2730 hypE +0.4 2.4 carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein (RefSeq) compare
b1126 potA +0.4 2.1 putrescine/spermidine ABC transporter ATPase protein (NCBI) compare
b4630 ykgP +0.4 1.2 no description compare
b2377 yfdY +0.4 1.2 predicted inner membrane protein (NCBI) compare
b1640 ydhH +0.4 1.6 anhydro-N-acetylmuramic acid kinase (NCBI) compare
b2706 gutM +0.4 1.5 DNA-binding transcriptional activator of glucitol operon (NCBI) compare
b1881 cheZ +0.4 1.1 chemotaxis regulator, protein phosphatase for CheY (NCBI) compare
b4515 ybgT +0.4 0.8 hypothetical protein (NCBI) compare
b0758 galT +0.4 2.2 galactose-1-phosphate uridylyltransferase (NCBI) compare
b0821 ybiU +0.4 2.5 hypothetical protein (NCBI) compare
b1494 pqqL +0.4 2.4 predicted peptidase (NCBI) compare
b1850 eda +0.4 1.0 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b0585 fes +0.4 2.0 enterobactin/ferric enterobactin esterase (NCBI) compare
b1123 potD +0.4 1.7 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b1523 yneG +0.4 0.8 hypothetical protein (NCBI) compare
b3293 yhdN +0.4 1.5 hypothetical protein (NCBI) compare
b2187 yejL +0.4 1.2 hypothetical protein (NCBI) compare
b4388 serB +0.4 2.1 3-phosphoserine phosphatase (NCBI) compare
b0367 tauC +0.4 1.6 taurine transporter subunit (NCBI) compare
b2205 napG +0.4 2.2 quinol dehydrogenase periplasmic component (NCBI) compare
b2637 yfjT +0.4 1.1 CP4-57 prophage; predicted protein (NCBI) compare
b2156 lysP +0.4 2.8 lysine transporter (NCBI) compare
b4360 yjjA +0.4 1.5 putative glycoprotein/receptor (VIMSS) compare
b4314 fimA +0.4 2.4 major type 1 subunit fimbrin (pilin) (NCBI) compare
b3206 npr +0.4 1.3 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b3742 mioC +0.4 1.2 flavodoxin (NCBI) compare
b2150 mglB +0.4 1.7 methyl-galactoside transporter subunit (NCBI) compare
b1946 fliN +0.4 1.1 flagellar motor switch protein (NCBI) compare
b0817 mntR +0.4 1.3 DNA-binding transcriptional regulator of mntH (NCBI) compare
b2288 nuoA +0.4 1.1 NADH dehydrogenase I chain A (VIMSS) compare
b2952 yggT +0.4 1.9 predicted inner membrane protein (NCBI) compare
b2250 b2250 +0.4 1.6 orf, hypothetical protein (VIMSS) compare
b4594 ymgJ +0.4 0.8 hypothetical protein (RefSeq) compare
b2015 yeeY +0.4 1.9 putative transcriptional regulator LYSR-type (VIMSS) compare
b0931 pncB +0.4 1.8 nicotinate phosphoribosyltransferase (NCBI) compare
b0263 afuB +0.4 0.8 CP4-6 prophage; predicted ferric trasnporter subunit (RefSeq) compare
b1790 yeaM +0.4 1.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b4414 tff +0.4 1.2 unknown RNA (NCBI) compare
b1680 sufS +0.4 2.1 selenocysteine lyase (NCBI) compare
b2782 chpA +0.4 1.5 toxin of the ChpA-ChpR toxin-antitoxin system, endoribonuclease (NCBI) compare
b0051 ksgA +0.4 1.4 dimethyladenosine transferase (NCBI) compare
b1221 narL +0.4 1.8 DNA-binding response regulator in two-component regulatory system with NarX (or NarQ) (NCBI) compare
b1060 yceP +0.4 1.4 orf, hypothetical protein (VIMSS) compare
b3924 fpr +0.4 1.6 ferredoxin-NADP reductase (NCBI) compare
b1053 mdtG +0.4 2.1 predicted drug efflux system (NCBI) compare
b2356 yfdM +0.4 1.0 orf, hypothetical protein (VIMSS) compare
b0401 brnQ +0.4 2.1 predicted branched chain amino acid transporter (LIV-II) (NCBI) compare
b0623 cspE +0.4 0.8 cold shock protein E (NCBI) compare
b4144 yjeI +0.4 1.0 orf, hypothetical protein (VIMSS) compare
b0775 bioB +0.3 1.7 biotin synthase (NCBI) compare
b0791 ybhQ +0.3 1.1 predicted inner membrane protein (NCBI) compare
b1660 ydhC +0.3 1.5 predicted transporter (NCBI) compare


Specific Phenotypes

For 1 genes in this experiment

For stress Sulfamonomethoxine in Escherichia coli BW25113

For stress Sulfamonomethoxine across organisms