Experiment set10IT028 for Escherichia coli BW25113

Compare to:

LB Aerobic with Phenazine ethosulfate 0.0000625 mM

200 most detrimental genes:

  gene name fitness t score description  
b0464 acrR +8.6 59.6 DNA-binding transcriptional repressor (NCBI) compare
b1684 sufA +7.4 18.3 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b2688 gshA +5.3 32.8 glutamate--cysteine ligase (NCBI) compare
b3493 pitA +5.0 34.2 phosphate transporter, low-affinity (NCBI) compare
b2175 spr +4.4 21.6 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b0439 lon +4.1 21.6 DNA-binding ATP-dependent protease La (NCBI) compare
b1676 pykF +3.7 20.0 pyruvate kinase (NCBI) compare
b2947 gshB +3.6 15.6 glutathione synthetase (NCBI) compare
b0605 ahpC +3.4 6.9 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b3164 pnp +3.1 9.1 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b1804 rnd +2.6 12.3 ribonuclease D (NCBI) compare
b1205 ychH +2.5 5.2 predicted inner membrane protein (NCBI) compare
b2684 mprA +2.4 11.7 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b4179 vacB +2.4 12.1 putative enzyme (VIMSS) compare
b3410 yhgG +2.4 15.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b4402 yjjY +2.4 4.6 hypothetical protein (NCBI) compare
b3409 feoB +2.3 21.4 ferrous iron transport protein B (NCBI) compare
b3198 kdsC +2.2 11.0 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b3250 mreC +2.2 1.3 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b3408 feoA +2.1 16.2 ferrous iron transport protein A (NCBI) compare
b4025 pgi +2.0 13.5 glucose-6-phosphate isomerase (NCBI) compare
b4089 rpiR +2.0 15.0 transcriptional repressor of rpiB expression (VIMSS) compare
b4215 ytfI +1.9 4.2 hypothetical protein (NCBI) compare
b3778 rep +1.9 12.3 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b3009 yghB +1.9 10.0 conserved inner membrane protein (NCBI) compare
b3916 pfkA +1.8 6.2 6-phosphofructokinase (NCBI) compare
b0853 ybjN +1.7 9.6 predicted oxidoreductase (NCBI) compare
b2912 ygfA +1.7 6.9 putative ligase (VIMSS) compare
b3546 yhjW +1.7 15.1 orf, hypothetical protein (VIMSS) compare
b3791 rffA +1.7 9.2 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b3836 b3836 +1.6 5.8 orf, hypothetical protein (VIMSS) compare
b2683 ygaH +1.6 4.4 predicted inner membrane protein (NCBI) compare
b4572 ylbE +1.6 2.0 no description compare
b0926 ycbK +1.6 5.7 hypothetical protein (NCBI) compare
b1249 cls +1.6 9.7 cardiolipin synthetase (NCBI) compare
b0606 ahpF +1.5 6.9 alkyl hydroperoxide reductase, F52a subunit; detoxification of hydroperoxides (VIMSS) compare
b3977 tyrU +1.5 1.9 tRNA-Tyr (NCBI) compare
b3397 nudE +1.5 11.0 ADP-ribose diphosphatase (NCBI) compare
b4481 rffT +1.5 8.1 4-alpha-L-fucosyltransferase (NCBI) compare
b1850 eda +1.4 1.7 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b1095 fabF +1.4 9.1 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b3912 cpxR +1.4 9.4 DNA-binding response regulator in two-component regulatory system with CpxA (NCBI) compare
b0448 mdlA +1.4 10.8 fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b2659 b2659 +1.4 2.7 orf, hypothetical protein (VIMSS) compare
b2516 yfgA +1.4 4.3 hypothetical protein (NCBI) compare
b1882 cheY +1.4 1.1 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b0889 lrp +1.3 1.7 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b1349 recT +1.3 6.3 Rac prophage; recombination and repair protein (NCBI) compare
b4373 rimI +1.3 4.7 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b2502 ppx +1.3 8.1 exopolyphosphatase (NCBI) compare
b3166 truB +1.3 8.1 tRNA pseudouridine synthase B (NCBI) compare
b1286 rnb +1.2 3.3 exoribonuclease II (NCBI) compare
b3806 cyaA +1.2 5.8 adenylate cyclase (NCBI) compare
b3790 rffC +1.2 7.3 TDP-fucosamine acetyltransferase (RefSeq) compare
b1811 yoaH +1.2 4.7 hypothetical protein (NCBI) compare
b2236 yfaE +1.2 2.4 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b2593 yfiH +1.2 8.6 hypothetical protein (NCBI) compare
b2058 wcaB +1.2 1.7 predicted acyl transferase (NCBI) compare
b0449 mdlB +1.2 8.6 fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b3006 exbB +1.2 8.2 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b1712 ihfA +1.2 1.6 integration host factor subunit alpha (NCBI) compare
b3401 yrfI +1.2 6.8 orf, hypothetical protein (VIMSS) compare
b0912 ihfB +1.2 3.0 integration host factor subunit beta (NCBI) compare
b2350 yfdG +1.2 6.0 CPS-53 (KpLE1) prophage; bactoprenol-linked glucose translocase (flippase) (NCBI) compare
b1661 cfa +1.1 5.8 cyclopropane fatty acyl phospholipid synthase (unsaturated-phospholipid methyltransferase) (NCBI) compare
b2582 trxC +1.1 4.7 thioredoxin 2 (NCBI) compare
b0632 dacA +1.1 7.6 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b3005 exbD +1.1 6.4 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b2448 yffQ +1.1 2.3 CPZ-55 prophage; predicted protein (RefSeq) compare
b3741 gidA +1.1 4.2 glucose-inhibited division protein A (NCBI) compare
b4651 yibW +1.1 0.5 no description compare
b1556 b1556 +1.1 2.2 orf, hypothetical protein (VIMSS) compare
b2421 cysM +1.1 4.4 cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) compare
b1010 ycdK +1.1 5.8 hypothetical protein (NCBI) compare
b1217 chaB +1.1 1.5 cation transport regulator (NCBI) compare
b1686 ydiI +1.1 2.6 hypothetical protein (NCBI) compare
b4647 mokA +1.1 0.5 no description compare
b2343 b2343 +1.1 2.5 orf, hypothetical protein (VIMSS) compare
b1854 pykA +1.1 6.3 pyruvate kinase (NCBI) compare
b2810 csdA +1.0 5.9 cysteine sulfinate desulfinase (NCBI) compare
b1273 yciN +1.0 2.4 hypothetical protein (NCBI) compare
b3600 mtlD +1.0 7.1 mannitol-1-phosphate 5-dehydrogenase (NCBI) compare
b3527 yhjJ +1.0 9.0 predicted zinc-dependent peptidase (NCBI) compare
b3504 yhiS +1.0 0.5 hypothetical protein (RefSeq) compare
b0549 ybcO +1.0 3.1 DLP12 prophage; predicted protein (NCBI) compare
b2635 ypjK +1.0 3.0 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b4660 yhiL +1.0 0.5 no description compare
b1607 ydgC +1.0 1.8 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b0407 yajC +1.0 2.7 preprotein translocase subunit YajC (NCBI) compare
b2181 yejG +1.0 3.4 hypothetical protein (NCBI) compare
b3442 yhhZ +1.0 0.5 hypothetical protein (NCBI) compare
b0065 yabI +1.0 4.8 conserved inner membrane protein (NCBI) compare
b1012 b1012 +1.0 3.7 orf, hypothetical protein (VIMSS) compare
b3959 argB +1.0 6.5 acetylglutamate kinase (RefSeq) compare
b1111 ycfQ +1.0 2.8 orf, hypothetical protein (VIMSS) compare
b3780 rhlB +1.0 7.0 ATP-dependent RNA helicase (NCBI) compare
b0143 pcnB +1.0 5.4 poly(A) polymerase I (VIMSS) compare
b2682 ygaZ +0.9 1.7 predicted transporter (NCBI) compare
b1827 kdgR +0.9 3.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b1148 ymfM +0.9 1.3 e14 prophage; predicted protein (NCBI) compare
b3706 trmE +0.9 3.1 tRNA modification GTPase (NCBI) compare
b3463 ftsE +0.9 0.6 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b3725 pstB +0.9 0.6 phosphate transporter subunit (NCBI) compare
b1097 yceG +0.9 3.9 predicted aminodeoxychorismate lyase (NCBI) compare
b4483 tatD +0.9 4.4 DNase, magnesium-dependent (NCBI) compare
b3842 rfaH +0.9 2.4 transcriptional activator RfaH (NCBI) compare
b2259 pmrD +0.9 1.1 polymyxin resistance protein B (VIMSS) compare
b4371 rsmC +0.9 5.8 16S ribosomal RNA m2G1207 methyltransferase (NCBI) compare
b2708 gutQ +0.9 3.6 orf, hypothetical protein (VIMSS) compare
b3740 gidB +0.9 6.8 glucose-inhibited division protein B (NCBI) compare
b2398 yfeC +0.9 2.1 orf, hypothetical protein (VIMSS) compare
b4409 blr +0.9 4.2 beta-lactam resistance membrane protein (NCBI) compare
b1782 mipA +0.9 2.7 scaffolding protein for murein synthesizing machinery (NCBI) compare
b2812 ygdL +0.9 5.2 hypothetical protein (NCBI) compare
b4387 ytjB +0.9 5.0 hypothetical protein (NCBI) compare
b3121 yhaC +0.9 0.4 hypothetical protein (NCBI) compare
b4279 yjhB +0.9 0.4 putative transport protein (VIMSS) compare
b4201 priB +0.9 2.3 primosomal replication protein N (NCBI) compare
b4650 yibS +0.8 1.5 no description compare
b1263 trpD +0.8 1.9 bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) compare
b1009 rarA +0.8 2.9 predicted hydrolase (NCBI) compare
b4128 yjdK +0.8 0.5 hypothetical protein (NCBI) compare
b1594 dgsA +0.8 2.7 DNA-binding transcriptional repressor (NCBI) compare
b1418 cybB +0.8 2.2 cytochrome b(561) (VIMSS) compare
b3348 slyX +0.8 2.4 hypothetical protein (NCBI) compare
b1008 ycdI +0.8 2.3 hypothetical protein (NCBI) compare
b2134 pbpG +0.8 4.1 penicillin-binding protein 7 (VIMSS) compare
b3027 ygiZ +0.8 0.4 conserved inner membrane protein (NCBI) compare
b3611 yibN +0.8 3.5 predicted rhodanese-related sulfurtransferase (NCBI) compare
b0114 aceE +0.8 1.2 pyruvate dehydrogenase subunit E1 (NCBI) compare
b4066 yjcF +0.8 0.4 hypothetical protein (NCBI) compare
b3622 rfaL +0.8 1.7 O-antigen ligase (NCBI) compare
b1066 rimJ +0.8 4.6 ribosomal-protein-S5-alanine N-acetyltransferase (NCBI) compare
b4036 lamB +0.8 5.8 maltoporin precursor (NCBI) compare
b2614 grpE +0.8 1.7 heat shock protein (NCBI) compare
b3838 tatB +0.8 4.2 sec-independent translocase (NCBI) compare
b2951 yggS +0.8 3.9 predicted enzyme (NCBI) compare
b1429 tehA +0.8 1.0 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b2847 yqeI +0.8 0.4 predicted transcriptional regulator (NCBI) compare
b2853 ygeI +0.8 0.4 hypothetical protein (NCBI) compare
b3386 rpe +0.8 0.7 ribulose-phosphate 3-epimerase (NCBI) compare
b0211 mltD +0.8 4.8 predicted membrane-bound lytic murein transglycosylase D (NCBI) compare
b2700 ygaD +0.8 3.6 competence damage-inducible protein A (NCBI) compare
b3623 rfaK +0.8 0.5 lipopolysaccharide core biosynthesis (NCBI) compare
b4041 plsB +0.8 1.9 glycerol-3-phosphate acyltransferase (VIMSS) compare
b1651 gloA +0.7 2.0 glyoxalase I, Ni-dependent (NCBI) compare
b4155 yjeA +0.7 0.4 putative lysyl-tRNA synthetase (VIMSS) compare
b0852 rimK +0.7 3.5 ribosomal protein S6 modification protein (NCBI) compare
b3190 yrbA +0.7 2.4 orf, hypothetical protein (VIMSS) compare
b2506 yfgI +0.7 1.4 hypothetical protein (NCBI) compare
b4407 thiS +0.7 1.8 sulfur carrier protein ThiS (NCBI) compare
b0658 ybeX +0.7 0.7 predicteed ion transport (NCBI) compare
b4173 hflX +0.7 3.3 predicted GTPase (NCBI) compare
b2673 nrdH +0.7 1.1 glutaredoxin-like protein (NCBI) compare
b0118 acnB +0.7 0.4 aconitate hydratase (NCBI) compare
b4443 gcvB +0.7 0.4 GcvB sRNA gene divergent from gcvA (RefSeq) compare
b0195 yaeB +0.7 4.0 hypothetical protein (NCBI) compare
b3029 ygiN +0.7 2.1 quinol monooxygenase (NCBI) compare
b0217 yafT +0.7 2.6 predicted aminopeptidase (NCBI) compare
b3875 ompL +0.7 1.1 predicted outer membrane porin L (NCBI) compare
b3418 malT +0.7 5.7 transcriptional regulator MalT (NCBI) compare
b1883 cheB +0.7 2.8 chemotaxis-specific methylesterase (NCBI) compare
b2791 yqcB +0.7 3.2 tRNA pseudouridine synthase (NCBI) compare
b2532 yfhQ +0.7 2.9 predicted methyltransferase (NCBI) compare
b3210 arcB +0.7 2.7 hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) compare
b3624 rfaZ +0.7 0.9 lipopolysaccharide core biosynthesis protein (NCBI) compare
b2946 yggJ +0.7 2.8 orf, hypothetical protein (VIMSS) compare
b1593 b1593 +0.7 2.4 orf, hypothetical protein (VIMSS) compare
b4017 arpA +0.7 1.5 regulator of acetyl CoA synthetase (NCBI) compare
b3350 kefB +0.7 5.5 glutathione-regulated potassium-efflux system protein (NCBI) compare
b0191 yaeJ +0.7 2.5 hypothetical protein (NCBI) compare
b0847 ybjL +0.7 2.9 hypothetical protein (NCBI) compare
b0121 speE +0.7 3.1 spermidine synthase (NCBI) compare
b2564 pdxJ +0.7 1.5 pyridoxal phosphate biosynthetic protein (NCBI) compare
b1186 nhaB +0.7 3.3 NhaB sodium/proton transporter (Katherine Huang) compare
b3028 mdaB +0.6 2.6 NADPH quinone reductase (NCBI) compare
b1618 uidR +0.6 2.4 DNA-binding transcriptional repressor (NCBI) compare
b1959 yedA +0.6 2.5 predicted inner membrane protein (NCBI) compare
b3500 gor +0.6 1.1 glutathione reductase (NCBI) compare
b2771 ygcS +0.6 3.2 putative transport protein (VIMSS) compare
b1610 tus +0.6 3.0 DNA replication terminus site-binding protein (NCBI) compare
b3911 cpxA +0.6 4.7 two-component sensor protein (NCBI) compare
b0425 panE +0.6 4.0 2-dehydropantoate 2-reductase (NCBI) compare
b4704 arrS +0.6 0.3 Antisense sRNA ArrS, function unknown (NCBI) compare
b2356 yfdM +0.6 1.7 orf, hypothetical protein (VIMSS) compare
b0500 ybbD +0.6 0.3 hypothetical protein (RefSeq) compare
b0393 rdgC +0.6 4.0 recombination associated protein (NCBI) compare
b2625 yfjI +0.6 0.8 CP4-57 prophage; predicted protein (NCBI) compare
b4391 yjjK +0.6 4.3 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1350 recE +0.6 2.5 Rac prophage; exonuclease VIII, 5' -> 3' specific dsDNA exonuclease (NCBI) compare
b1502 ydeQ +0.6 1.0 predicted fimbrial-like adhesin protein (NCBI) compare
b0279 yagM +0.6 0.4 CP4-6 prophage; predicted protein (NCBI) compare
b3993 thiE +0.6 1.7 thiamine-phosphate pyrophosphorylase (NCBI) compare
b1948 fliP +0.6 1.3 flagellar biosynthesis protein P (NCBI) compare
b4175 hflC +0.6 4.0 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b3812 yigB +0.6 2.9 predicted hydrolase (NCBI) compare
b3483 yhhH +0.6 0.3 orf, hypothetical protein (VIMSS) compare
b3926 glpK +0.6 5.1 glycerol kinase (NCBI) compare
b1582 ynfA +0.6 1.6 hypothetical protein (NCBI) compare
b0603 ybdO +0.6 0.3 predicted DNA-binding transcriptional regulator (NCBI) compare


Specific Phenotypes

For 41 genes in this experiment

For stress Phenazine ethosulfate in Escherichia coli BW25113

For stress Phenazine ethosulfate across organisms