Experiment set10IT004 for Escherichia coli BW25113

Compare to:

LB Aerobic with Phenazine ethosulfate 0.0000625 mM

200 most detrimental genes:

  gene name fitness t score description  
b0464 acrR +9.7 71.8 DNA-binding transcriptional repressor (NCBI) compare
b1684 sufA +7.4 12.7 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b2688 gshA +5.8 36.2 glutamate--cysteine ligase (NCBI) compare
b3493 pitA +5.6 37.2 phosphate transporter, low-affinity (NCBI) compare
b2175 spr +5.1 27.4 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b0605 ahpC +5.0 11.8 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b0439 lon +4.6 21.2 DNA-binding ATP-dependent protease La (NCBI) compare
b2947 gshB +4.2 16.4 glutathione synthetase (NCBI) compare
b1676 pykF +4.0 21.2 pyruvate kinase (NCBI) compare
b3164 pnp +3.7 8.6 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b4179 vacB +3.0 15.8 putative enzyme (VIMSS) compare
b4402 yjjY +2.7 4.9 hypothetical protein (NCBI) compare
b2683 ygaH +2.6 6.4 predicted inner membrane protein (NCBI) compare
b4089 rpiR +2.5 17.4 transcriptional repressor of rpiB expression (VIMSS) compare
b3778 rep +2.4 17.0 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1205 ychH +2.4 7.5 predicted inner membrane protein (NCBI) compare
b1804 rnd +2.4 11.9 ribonuclease D (NCBI) compare
b0889 lrp +2.4 2.0 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b4066 yjcF +2.3 1.9 hypothetical protein (NCBI) compare
b1217 chaB +2.2 3.3 cation transport regulator (NCBI) compare
b3916 pfkA +2.2 7.1 6-phosphofructokinase (NCBI) compare
b3409 feoB +2.2 19.2 ferrous iron transport protein B (NCBI) compare
b4572 ylbE +2.1 2.8 no description compare
b3250 mreC +2.1 1.4 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b1095 fabF +2.1 12.6 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b3408 feoA +2.0 16.1 ferrous iron transport protein A (NCBI) compare
b4025 pgi +2.0 12.4 glucose-6-phosphate isomerase (NCBI) compare
b3410 yhgG +1.9 11.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b1712 ihfA +1.9 2.5 integration host factor subunit alpha (NCBI) compare
b2912 ygfA +1.9 5.7 putative ligase (VIMSS) compare
b3979 thrT +1.9 1.1 tRNA-Thr (NCBI) compare
b3397 nudE +1.8 14.2 ADP-ribose diphosphatase (NCBI) compare
b0841 ybjG +1.8 2.1 undecaprenyl pyrophosphate phosphatase (NCBI) compare
b3009 yghB +1.8 9.3 conserved inner membrane protein (NCBI) compare
b3791 rffA +1.8 10.6 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b3198 kdsC +1.7 5.8 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b2659 b2659 +1.7 2.1 orf, hypothetical protein (VIMSS) compare
b3806 cyaA +1.7 8.2 adenylate cyclase (NCBI) compare
b4651 yibW +1.7 0.8 no description compare
b0853 ybjN +1.7 5.6 predicted oxidoreductase (NCBI) compare
b0926 ycbK +1.7 6.7 hypothetical protein (NCBI) compare
b4647 mokA +1.7 0.8 no description compare
b1249 cls +1.6 9.3 cardiolipin synthetase (NCBI) compare
b3504 yhiS +1.6 0.8 hypothetical protein (RefSeq) compare
b3546 yhjW +1.6 14.8 orf, hypothetical protein (VIMSS) compare
b4660 yhiL +1.6 0.8 no description compare
b1346 ydaQ +1.6 2.4 orf, hypothetical protein (VIMSS) compare
b3442 yhhZ +1.6 0.8 hypothetical protein (NCBI) compare
b3912 cpxR +1.6 8.5 DNA-binding response regulator in two-component regulatory system with CpxA (NCBI) compare
b1850 eda +1.6 1.8 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b3463 ftsE +1.5 1.0 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b4552 yrhC +1.5 1.5 no description compare
b4481 rffT +1.5 7.3 4-alpha-L-fucosyltransferase (NCBI) compare
b3121 yhaC +1.5 0.7 hypothetical protein (NCBI) compare
b4279 yjhB +1.5 0.7 putative transport protein (VIMSS) compare
b3027 ygiZ +1.5 0.7 conserved inner membrane protein (NCBI) compare
b3623 rfaK +1.5 1.8 lipopolysaccharide core biosynthesis (NCBI) compare
b3725 pstB +1.5 0.9 phosphate transporter subunit (NCBI) compare
b4128 yjdK +1.5 0.8 hypothetical protein (NCBI) compare
b2847 yqeI +1.5 0.7 predicted transcriptional regulator (NCBI) compare
b2853 ygeI +1.5 0.7 hypothetical protein (NCBI) compare
b0118 acnB +1.5 0.8 aconitate hydratase (NCBI) compare
b0449 mdlB +1.4 9.6 fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1103 ycfF +1.4 2.5 orf, hypothetical protein (VIMSS) compare
b4443 gcvB +1.4 0.7 GcvB sRNA gene divergent from gcvA (RefSeq) compare
b2682 ygaZ +1.4 2.1 predicted transporter (NCBI) compare
b4201 priB +1.4 4.1 primosomal replication protein N (NCBI) compare
b3741 gidA +1.4 4.8 glucose-inhibited division protein A (NCBI) compare
b3706 trmE +1.4 4.1 tRNA modification GTPase (NCBI) compare
b4503 yafF +1.4 0.9 no description compare
b3624 rfaZ +1.4 2.3 lipopolysaccharide core biosynthesis protein (NCBI) compare
b0114 aceE +1.4 1.7 pyruvate dehydrogenase subunit E1 (NCBI) compare
b0500 ybbD +1.4 0.7 hypothetical protein (RefSeq) compare
b4155 yjeA +1.4 0.8 putative lysyl-tRNA synthetase (VIMSS) compare
b2297 pta +1.4 0.7 phosphate acetyltransferase (NCBI) compare
b1008 ycdI +1.3 3.4 hypothetical protein (NCBI) compare
b0279 yagM +1.3 0.8 CP4-6 prophage; predicted protein (NCBI) compare
b0603 ybdO +1.3 0.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b2516 yfgA +1.3 5.2 hypothetical protein (NCBI) compare
b0448 mdlA +1.3 9.4 fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b3622 rfaL +1.3 2.3 O-antigen ligase (NCBI) compare
b2569 lepA +1.3 4.3 GTP-binding protein LepA (NCBI) compare
b0705 ybfL +1.3 0.6 putative receptor protein (VIMSS) compare
b4048 yjbM +1.3 1.4 hypothetical protein (NCBI) compare
b1263 trpD +1.3 3.0 bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) compare
b0912 ihfB +1.3 4.3 integration host factor subunit beta (NCBI) compare
b2502 ppx +1.3 7.3 exopolyphosphatase (NCBI) compare
b2055 wcaE +1.3 0.6 predicted glycosyl transferase (NCBI) compare
b0142 folK +1.3 1.0 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b3183 obgE +1.2 1.3 GTPase involved in cell partioning and DNA repair (NCBI) compare
b0234 yafP +1.2 1.3 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b2352 yfdI +1.2 0.7 CPS-53 (KpLE1) prophage; predicted inner membrane protein (NCBI) compare
b1576 ydfD +1.2 0.6 Qin prophage; predicted protein (NCBI) compare
b3386 rpe +1.2 0.8 ribulose-phosphate 3-epimerase (NCBI) compare
b3875 ompL +1.2 1.8 predicted outer membrane porin L (NCBI) compare
b4462 ygaQ +1.2 1.1 hypothetical protein (RefSeq) compare
b4253 yjgL +1.2 3.3 orf, hypothetical protein (VIMSS) compare
b1349 recT +1.2 5.8 Rac prophage; recombination and repair protein (NCBI) compare
b0658 ybeX +1.2 0.7 predicteed ion transport (NCBI) compare
b1347 ydaC +1.2 0.6 Rac prophage; predicted protein (NCBI) compare
b1497 b1497 +1.2 0.6 putative enzyme (VIMSS) compare
b1351 racC +1.2 0.6 Rac prophage; predicted protein (NCBI) compare
b1167 ymgC +1.2 0.6 hypothetical protein (NCBI) compare
b1499 ydeO +1.2 0.6 predicted DNA-binding transcriptional acfivator (NCBI) compare
b4650 yibS +1.2 1.6 no description compare
b1001 yccE +1.2 0.6 hypothetical protein (NCBI) compare
b4593 ymgI +1.2 0.6 hypothetical protein (RefSeq) compare
b2846 yqeH +1.2 0.7 orf, hypothetical protein (VIMSS) compare
b0606 ahpF +1.2 6.3 alkyl hydroperoxide reductase, F52a subunit; detoxification of hydroperoxides (VIMSS) compare
b3723 bglG +1.2 3.4 transcriptional antiterminator of the bgl operon (NCBI) compare
b1257 yciE +1.2 0.6 hypothetical protein (NCBI) compare
b4017 arpA +1.2 2.3 regulator of acetyl CoA synthetase (NCBI) compare
b2652 ileY +1.2 0.7 tRNA-Ile (NCBI) compare
b1553 ydfP +1.2 3.0 Qin prophage; conserved protein (NCBI) compare
b3790 rffC +1.2 4.9 TDP-fucosamine acetyltransferase (RefSeq) compare
b1363 trkG +1.2 0.7 Rac prophage; potassium transporter subunit (NCBI) compare
b0326 yahL +1.2 1.1 hypothetical protein (NCBI) compare
b4497 yeeL +1.2 0.7 no description compare
b4345 mcrC +1.2 0.7 5-methylcytosine-specific restriction enzyme McrBC, subunit McrC (NCBI) compare
b2350 yfdG +1.2 6.6 CPS-53 (KpLE1) prophage; bactoprenol-linked glucose translocase (flippase) (NCBI) compare
b0303 ykgI +1.1 0.7 orf, hypothetical protein (VIMSS) compare
b1661 cfa +1.1 5.8 cyclopropane fatty acyl phospholipid synthase (unsaturated-phospholipid methyltransferase) (NCBI) compare
b2181 yejG +1.1 4.8 hypothetical protein (NCBI) compare
b0632 dacA +1.1 6.9 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b2934 cmtB +1.1 0.7 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b2625 yfjI +1.1 0.8 CP4-57 prophage; predicted protein (NCBI) compare
b3290 trkA +1.1 1.3 potassium transporter peripheral membrane component (NCBI) compare
b3401 yrfI +1.1 6.5 orf, hypothetical protein (VIMSS) compare
b1010 ycdK +1.1 3.8 hypothetical protein (NCBI) compare
b0065 yabI +1.1 4.5 conserved inner membrane protein (NCBI) compare
b1690 ydiM +1.1 1.5 predicted transporter (NCBI) compare
b3166 truB +1.1 6.8 tRNA pseudouridine synthase B (NCBI) compare
b1165 ymgA +1.1 0.6 hypothetical protein (NCBI) compare
b1182 hlyE +1.1 0.6 hemolysin E (VIMSS) compare
b2448 yffQ +1.1 2.5 CPZ-55 prophage; predicted protein (RefSeq) compare
b4590 ybfK +1.1 1.2 hypothetical protein (RefSeq) compare
b2259 pmrD +1.1 1.2 polymyxin resistance protein B (VIMSS) compare
b2504 yfgG +1.1 0.7 Negative regulator of nickel and cobalt uptake (YfgG) (from data) compare
b3527 yhjJ +1.1 9.6 predicted zinc-dependent peptidase (NCBI) compare
b4451 ryhB +1.1 1.8 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b0310 ykgH +1.1 0.7 predicted inner membrane protein (NCBI) compare
b1854 pykA +1.1 6.2 pyruvate kinase (NCBI) compare
b1608 rstA +1.1 2.6 DNA-binding response regulator in two-component regulatory system with RstB (RefSeq) compare
b1409 ynbB +1.0 0.7 predicted CDP-diglyceride synthase (NCBI) compare
b1505 ydeT +1.0 0.9 hypothetical protein (RefSeq) compare
b3462 ftsX +1.0 2.3 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b3180 yhbY +1.0 5.6 predicted RNA-binding protein (NCBI) compare
b1551 b1551 +1.0 0.6 orf, hypothetical protein (VIMSS) compare
b4215 ytfI +1.0 1.1 hypothetical protein (NCBI) compare
b4387 ytjB +1.0 4.2 hypothetical protein (NCBI) compare
b2699 recA +1.0 0.9 recombinase A (NCBI) compare
b4687 shoB +1.0 2.5 toxic membrane protein (RefSeq) compare
b2810 csdA +1.0 5.6 cysteine sulfinate desulfinase (NCBI) compare
b1097 yceG +1.0 4.4 predicted aminodeoxychorismate lyase (NCBI) compare
b3138 agaB +1.0 1.1 N-acetylgalactosamine-specific enzyme IIB component of PTS (NCBI) compare
b4172 hfq +1.0 0.6 RNA-binding protein Hfq (NCBI) compare
b0125 hpt +1.0 4.6 hypoxanthine phosphoribosyltransferase (VIMSS) compare
b0136 yadK +1.0 1.8 predicted fimbrial-like adhesin protein (NCBI) compare
b0143 pcnB +1.0 4.5 poly(A) polymerase I (VIMSS) compare
b1011 b1011 +1.0 2.0 putative synthetase (VIMSS) compare
b3005 exbD +1.0 3.3 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b0407 yajC +1.0 2.4 preprotein translocase subunit YajC (NCBI) compare
b1111 ycfQ +1.0 2.1 orf, hypothetical protein (VIMSS) compare
b0738 tolR +1.0 1.9 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1143 ymfI +1.0 0.9 orf, hypothetical protein (VIMSS) compare
b4042 dgkA +1.0 1.9 diacylglycerol kinase (NCBI) compare
b1258 yciF +1.0 0.6 hypothetical protein (NCBI) compare
b2110 yehC +0.9 1.0 predicted periplasmic pilin chaperone (NCBI) compare
b0121 speE +0.9 3.1 spermidine synthase (NCBI) compare
b3210 arcB +0.9 4.3 hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) compare
b1380 ldhA +0.9 2.1 D-lactate dehydrogenase (NCBI) compare
b1968 yedV +0.9 1.3 predicted sensory kinase in two-component regulatory system with YedW (NCBI) compare
b4483 tatD +0.9 4.4 DNase, magnesium-dependent (NCBI) compare
b4373 rimI +0.9 2.8 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b1762 b1762 +0.9 1.2 orf, hypothetical protein (VIMSS) compare
b3119 tdcR +0.9 2.4 threonine dehydratase operon activator protein (VIMSS) compare
b2506 yfgI +0.9 2.0 hypothetical protein (NCBI) compare
b4545 ypdJ +0.9 1.7 no description compare
b4436 ryeC +0.9 1.7 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b1329 b1329 +0.9 2.1 putative transport periplasmic protein (VIMSS) compare
b2946 yggJ +0.9 4.2 orf, hypothetical protein (VIMSS) compare
b1070 flgN +0.9 1.4 export chaperone for FlgK and FlgL (NCBI) compare
b3350 kefB +0.9 7.0 glutathione-regulated potassium-efflux system protein (NCBI) compare
b1130 phoP +0.9 0.6 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b3740 gidB +0.9 6.4 glucose-inhibited division protein B (NCBI) compare
b0393 rdgC +0.9 5.0 recombination associated protein (NCBI) compare
b3863 polA +0.9 0.6 DNA polymerase I (NCBI) compare
b3057 bacA +0.9 2.8 undecaprenyl pyrophosphate phosphatase (NCBI) compare
b3959 argB +0.9 6.0 acetylglutamate kinase (RefSeq) compare
b1573 ydfC +0.9 1.4 Qin prophage; predicted protein (RefSeq) compare
b2186 yejK +0.9 6.1 nucleoid-associated protein NdpA (NCBI) compare
b4704 arrS +0.9 0.4 Antisense sRNA ArrS, function unknown (NCBI) compare
b1502 ydeQ +0.9 0.9 predicted fimbrial-like adhesin protein (NCBI) compare
b3483 yhhH +0.9 0.4 orf, hypothetical protein (VIMSS) compare
b2593 yfiH +0.9 5.7 hypothetical protein (NCBI) compare
b1696 ydiP +0.9 1.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b1648 b1648 +0.9 1.6 orf, hypothetical protein (VIMSS) compare
b1527 yneK +0.8 1.5 hypothetical protein (NCBI) compare
b4494 arpB +0.8 0.6 no description compare
b2758 ygcJ +0.8 2.1 hypothetical protein (NCBI) compare


Specific Phenotypes

For 24 genes in this experiment

For stress Phenazine ethosulfate in Escherichia coli BW25113

For stress Phenazine ethosulfate across organisms