Protein Info for QEN71_RS38495 in Paraburkholderia sabiae LMG 24235

Annotation: NAD-dependent succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 456 PF00171: Aldedh" amino acids 3 to 452 (450 residues), 444.1 bits, see alignment E=2.5e-137

Best Hits

Swiss-Prot: 50% identical to GABD_DEIRA: Succinate-semialdehyde dehydrogenase [NADP(+)] (ssdA) from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 59% identity to bge:BC1002_4059)

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16

Use Curated BLAST to search for 1.2.1.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (456 amino acids)

>QEN71_RS38495 NAD-dependent succinate-semialdehyde dehydrogenase (Paraburkholderia sabiae LMG 24235)
MSFVTVNPATGKVVKEFPLQSDEQVFAALSAADKRYHEDWKFRPVAERAAIVRRAAQILR
EKRDEYATYPTLEMGKIVRFSYMEIDLVADILDYYAEHGEKFLAPQAVPGEPGATLVAEP
IGVLLAIEPWNFPFYQLVRVAAPQLVAGNVVLMKHAENVPQCALAFARLFEEAGAPEGVY
TNLFCSIDQIAKLIDDFRVRGVALTGSERAGASVGERAGRNMKKAILELGGSDPALILEG
ASLDHAVEQCVMGRTFNSGQGCVNIKRVIVVGKERGEKMLAALSKQFAAIKVGDPTDEAT
TLGPLVSERALEGLLRQIDEAKAAGARIVSGGKRVDRPGFYLEPTIVTDIDEDNPLYQQE
AFGPVLSFYVVESEDEAIRLANATKYGLGAFVFDTDVEHAKQVASRIESGMVYINSCFAD
SPGLPFGGIKNSGFGRELSELGIGEFLNRKLVRVAQ