Protein Info for QEN71_RS38440 in Paraburkholderia sabiae LMG 24235

Annotation: multidrug effflux MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 404 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 46 to 64 (19 residues), see Phobius details amino acids 74 to 94 (21 residues), see Phobius details amino acids 102 to 125 (24 residues), see Phobius details amino acids 137 to 158 (22 residues), see Phobius details amino acids 164 to 183 (20 residues), see Phobius details amino acids 217 to 241 (25 residues), see Phobius details amino acids 248 to 268 (21 residues), see Phobius details amino acids 280 to 303 (24 residues), see Phobius details amino acids 309 to 328 (20 residues), see Phobius details amino acids 344 to 366 (23 residues), see Phobius details amino acids 372 to 393 (22 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 6 to 385 (380 residues), 213.5 bits, see alignment E=3.2e-67 PF07690: MFS_1" amino acids 17 to 357 (341 residues), 135.9 bits, see alignment E=2.6e-43 PF00083: Sugar_tr" amino acids 43 to 172 (130 residues), 40.4 bits, see alignment E=2.8e-14 PF06609: TRI12" amino acids 46 to 182 (137 residues), 26.2 bits, see alignment E=4.3e-10

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 39% identity to dal:Dalk_2258)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (404 amino acids)

>QEN71_RS38440 multidrug effflux MFS transporter (Paraburkholderia sabiae LMG 24235)
MKKHESIFFTLFLGALSAIAPLSIDMGLPGIPAIEATFSDAGSRGSMTLSLFLVGFSAAP
LFIGPLSDRFGRRIALIAGLSFFSAAAICSAFAPSFTTLLLARFVQGAAGGAIATLPVVM
VRDVLEGPSARAKLSQIVAILGIAPIVAPLIGAAILAIGSWRSIYLAQALVGVVELFIAA
TWLEETHPRERRRSLGIRVLLDGYRTILSDGSFTRYGLVYTFSFTCMFSYISTSPAVFMS
TFALSDRWFSVLFSITSAGVMAGALLSARLSRRFHKHETVVAAGLGCMVLSTIALVTIAS
LGLSSAYEIAALATIVMLTFGAIAGPCNHAALSDLGHVAGSAAGLMRCFQMLSAGIASAL
GATLAASIDHVYVMVGLMLGAAMLAGLAFVVPLRPLRRQEQMRL