Protein Info for QEN71_RS38170 in Paraburkholderia sabiae LMG 24235
Annotation: intradiol ring-cleavage dioxygenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 50% identical to NPCC_RHOOP: Hydroxyquinol 1,2-dioxygenase (npcC) from Rhodococcus opacus
KEGG orthology group: K03381, catechol 1,2-dioxygenase [EC: 1.13.11.1] (inferred from 94% identity to bph:Bphy_5624)MetaCyc: 66% identical to 1,2,4-trihydroxybenzene 1,2-dioxygenase monomer (Pseudomonas putida DLL-E4)
Hydroxyquinol 1,2-dioxygenase. [EC: 1.13.11.37]
Predicted SEED Role
"Catechol 1,2-dioxygenase 1 (EC 1.13.11.1)" in subsystem Catechol branch of beta-ketoadipate pathway (EC 1.13.11.1)
MetaCyc Pathways
- aromatic compounds degradation via β-ketoadipate (9/9 steps found)
- superpathway of salicylate degradation (7/7 steps found)
- catechol degradation III (ortho-cleavage pathway) (6/6 steps found)
- catechol degradation to β-ketoadipate (4/4 steps found)
- resorcinol degradation (2/3 steps found)
- 4-nitrophenol degradation II (3/5 steps found)
- γ-resorcylate degradation I (2/4 steps found)
- γ-resorcylate degradation II (2/4 steps found)
- 4-aminophenol degradation (2/4 steps found)
- 2,4,5-trichlorophenoxyacetate degradation (5/9 steps found)
- mandelate degradation to acetyl-CoA (10/18 steps found)
- superpathway of aromatic compound degradation via 3-oxoadipate (22/35 steps found)
KEGG Metabolic Maps
- 1,4-Dichlorobenzene degradation
- Benzoate degradation via hydroxylation
- Carbazole degradation
- Fluorobenzoate degradation
- Toluene and xylene degradation
- gamma-Hexachlorocyclohexane degradation
Isozymes
Compare fitness of predicted isozymes for: 1.13.11.1
Use Curated BLAST to search for 1.13.11.1 or 1.13.11.37
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (293 amino acids)
>QEN71_RS38170 intradiol ring-cleavage dioxygenase (Paraburkholderia sabiae LMG 24235) MSTDEREAERALTEQVVASFANTEDARLRTLMQSLIRHMHAFVREVEPTEAEWMSAIRFL TATGKMCDDLVRQEFILLSDTLGVSMLVDAINHRLATGATDTTVFGPFYIEGMPERAYGE NMAFTPGAPALVHGRVLTTTGEPIAGALLDVWQTADNGMYSGQDTAQPHGNLRGRYRTDA EGRYAITTIVPVSYPIPTDGPVGQMLEATGRHPWRPAHLHFMIKAPDYRTLVTHLFDKDD PYLQSDAVFGVKPSLMVAYDERSAEDELARRFGFNGSYREARYDFVLDGSAAS