Protein Info for QEN71_RS36430 in Paraburkholderia sabiae LMG 24235

Annotation: bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1255 PF18327: PRODH" amino acids 17 to 63 (47 residues), 36.4 bits, see alignment (E = 1e-12) PF14850: Pro_dh-DNA_bdg" amino acids 72 to 183 (112 residues), 139.7 bits, see alignment E=1.1e-44 PF01619: Pro_dh" amino acids 197 to 486 (290 residues), 334.5 bits, see alignment E=1.2e-103 PF00171: Aldedh" amino acids 575 to 1000 (426 residues), 240.3 bits, see alignment E=6.6e-75

Best Hits

Predicted SEED Role

"Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12)" in subsystem Arginine and Ornithine Degradation or Proline, 4-hydroxyproline uptake and utilization or Respiratory dehydrogenases 1 (EC 1.5.1.12, EC 1.5.99.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.5.1.12, 1.5.99.8

Use Curated BLAST to search for 1.5.1.12 or 1.5.99.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1255 amino acids)

>QEN71_RS36430 bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA (Paraburkholderia sabiae LMG 24235)
MLSEIQTMQSSSADLHTLRQRIRDASSLPEDVVVRGLMDEARMDAPTLARAQDLAARLAQ
GVRDARINAGGVDLLTQEFSLDSREGIALMCLAEAMLRIPDTETRNQLIRDKIVDADWRA
HIGKSPSLFVNATAWGLLFTGKLLKQPDENALAEALSRVVRKGGEAVVRAGVAYAMRMLG
KQFVTGQTIEEAIGVARGRESGGYRYTYDMLGEAALTDEDAQAYFESYRHAIEAIGKEAK
GQGPIDGPGVSVKISGLHPRYELAQRDRVLSEMYPRLLQLAQTAKKYGIGFHLDQEESAR
FDLTLEMLERLCAEPSLKGWNGIGISLQAYQKRGRAVADWIIALARANGRRINIRLVKGA
YWDTEIKLAQDAGAVGYPVFTRKVHSDVSYIACAKALLNAPDAIFPQFASHNAFTVAAVH
TLAGDKAYEFQCLHGMGETVYDQVVGATKLNRPCRIYAPVGPHATLLAYLVRRLLENGAN
SSFVNQIVDPAVSIADIVEDPVAKAARTGGAPHAGIASPRNLLPGRLNAVSLSFAGAPEF
ERAVADIRQNRVNAYSLIAGSADAKSESTTVVYSASNLVEAIGSFASCKMDSVAGALDAA
AQAMAAWGGRTAADRSDVLERVASDLETHAARLGALLSLENGATLSEAAEEVRTAVNLCR
LYAFQVKTDKALADALPLGTVISVTPSASPLSTFVGQVSAALAAGNAVIAKPSSDASLIA
FEATRVFHGAGVPQDVLQLALGNGATMAKALVSDQRVAAVLFAGSREIARAIAVQLAAAE
RPAKLIATYGSVNSMIVDSSALPEQVISDAIVSAFTSAGQGASSLRILCLQDSTADKVLR
MLNGMLSERNTDDPLSSATDVGPVATRKARDAAETYIEQLKRRGFGISRGKLGAGCGNGN
FVAPTIADIGDVGSLAAIDPSVTGPILHVVRYETGNMEALIRALNALGSGVQGLHTRINE
TAGNLLSFSEASSICINRAMHAAFPGMQPAGGNGVSGTGSMVAGPLTLIGLTRSSAGTYA
ADTGPFAPSRTAVSEKYLEFPVASAEGRLVGRMTAQAQASASYRQRVEAIANTSAARRLD
PGAQARLGRCKAEVLRLAERFRPLSLPALTGEENTVELLPRGQVLCAAHSVESLLVQATA
ACAFGNDVLLLKSSVADEIAAALRTGCRVVDSADAARVLDGEVPGVRPNVVLVTSEQRGV
GNLRRMAASRMIDVAVTRDDGTYDWTQLVRERVTTVNASAAGGNTQLMVMSEDAV