Protein Info for QEN71_RS36020 in Paraburkholderia sabiae LMG 24235

Annotation: choline dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 544 PF00732: GMC_oxred_N" amino acids 7 to 296 (290 residues), 170.6 bits, see alignment E=8.9e-54 PF00890: FAD_binding_2" amino acids 8 to 259 (252 residues), 22.3 bits, see alignment E=1.5e-08 PF05199: GMC_oxred_C" amino acids 387 to 525 (139 residues), 133.5 bits, see alignment E=1.7e-42

Best Hits

Swiss-Prot: 44% identical to BETA_PARP8: Oxygen-dependent choline dehydrogenase (betA) from Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)

KEGG orthology group: K00108, choline dehydrogenase [EC: 1.1.99.1] (inferred from 44% identity to cfa:484723)

MetaCyc: 44% identical to choline dehydrogenase (Homo sapiens)
Choline dehydrogenase. [EC: 1.1.99.1]

Predicted SEED Role

"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.99.1

Use Curated BLAST to search for 1.1.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (544 amino acids)

>QEN71_RS36020 choline dehydrogenase (Paraburkholderia sabiae LMG 24235)
MSEALEFDYVIGGAGSAGCVLARRLADAGNRVLLIEAGPRDNSWVIRMPAGLRSIFKPSS
RYNYWFETEPQRNLDNRRIQQPRGRVLGGSSSINGMTWLRGHPLDYERWEREGATGWSWA
DCLPYFRKIERSDVSSAYRGTDGFIHAQRQERLSPLNQAFLDAGVEAGFPLTDDVNGYRQ
EGVSRFEMSVDRGIRNSAAYGYLHSRKEDANLTIWTQSALKQINLIGNRATGFKVLRGDS
VVNVVARKETLLCAGVFGSPQLLMLSGIGPGDHLHETGIAPRVELPGVGENLQDHLECHI
QIETREPVSLNRELQLHRMLWAGMQWFGFKSGVASVNQCHVGAFLKSASHIPHPDIQFHF
FPVFFNKDWIPTPQTNGYRIGVGPMRPTSRGRVRLKSMRAEDPLSIDPNYMNTEEDWRVM
RESVRLGLLFSRQAAFRRFHYREDMPGVDVSATAAIDQFIRQDASSAYHPCGTCKMGAKH
DATAVVGPDLKVRGVERLRVIDASVMPSVPSANINAATIMLAERASDLVLGRATMRAEPL
QFVA