Protein Info for QEN71_RS35965 in Paraburkholderia sabiae LMG 24235

Annotation: EAL domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 981 transmembrane" amino acids 20 to 40 (21 residues), see Phobius details amino acids 195 to 214 (20 residues), see Phobius details amino acids 221 to 241 (21 residues), see Phobius details amino acids 261 to 278 (18 residues), see Phobius details amino acids 289 to 308 (20 residues), see Phobius details amino acids 314 to 336 (23 residues), see Phobius details amino acids 344 to 369 (26 residues), see Phobius details amino acids 375 to 394 (20 residues), see Phobius details PF07695: 7TMR-DISM_7TM" amino acids 197 to 396 (200 residues), 31.1 bits, see alignment E=3.4e-11 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 522 to 679 (158 residues), 103.9 bits, see alignment E=3.8e-34 PF00990: GGDEF" amino acids 525 to 675 (151 residues), 109.1 bits, see alignment E=3e-35 PF00563: EAL" amino acids 708 to 935 (228 residues), 199.9 bits, see alignment E=6.4e-63

Best Hits

KEGG orthology group: None (inferred from 88% identity to bph:Bphy_6051)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (981 amino acids)

>QEN71_RS35965 EAL domain-containing protein (Paraburkholderia sabiae LMG 24235)
MTGVRGAFRDRLTGWAFHRFSVFIAPFVIALGSIAVMLWAPRQFDTTGTVRLSFPVVADP
SADLSPASALARLRDAEPTARFKTHLAETPFWFLLNAPDVASEGATYIDLPSRHAQTLSC
WRAGPDLTLLGTGDRLGTSGLISSNKAGFVLRLDERAPHAPILCKGTFSGPAYISASVTS
EEKLEVTTLDFQQSASLITGGLLTLAIFVFVTAIINREWTYVIFAAWLVGNLRLSANAMG
FDTEWLGRLIPPNHIAFLREFTFAAYYVLTTTLFVELFRRELKAIGLRWSLHAVRYGGCL
LMAAAFVLDYRHFIPVLWSSASFCILVLTYFMVQLVIKGRSRTVLWYVASMGIVLIATLS
EVLAAAFGLKALEGTLSPVVTALSSSMLCAFAIAERMREERERRRQMQIELRNTYDVTPI
GLFTLNSDNCFVRANPALHTMLGLPLEHYATHRWADYFSSGAERDMYALLERDDSASIEI
DGAAGTRTDARRYSLRAIRANGFIEGSLEDVTDRSKAVARLHFLAEHDPLTGLLNRLGIE
HAIERQCAENGPWALAYLDLDRFKVFNDLFGHGTGDEILRQVAARIVERLGPDVAIGRIG
GDEFVCVLSNMTIDEAIARCREIVEALNSAPVPVDTRAFQVRGSIGVVECAQGERVRDAL
AYADRACRAAKRGGSARLVALRKGAPAFEERTAEINLIEALGQSRLPDGLFLVMQPIMSM
REPTKALDFEVLLRMRSPDGAVATAGKLIAAAEDSGTIVEIDRWVLSTTLAWLSEHRASL
VNTRFVCVNLSGGSLNDEHFLDELFALLSRYEDVVHYLCIEITESVALHDLEHTERFIAR
VHDMGAKIAIDDFGAGHTSLRYLKKLSADALKIDGEFVRTMCNHPADIAIVEAIISLAHN
LGMRSIAEWVEDLETLRALNELGVDYVQGFGIAKPQETTAILAASSAASFVTNAEIVHYL
QVERAQQRGAGQPSVERENAV