Protein Info for QEN71_RS33235 in Paraburkholderia sabiae LMG 24235

Annotation: sensor domain-containing diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 505 transmembrane" amino acids 38 to 58 (21 residues), see Phobius details amino acids 65 to 86 (22 residues), see Phobius details amino acids 103 to 123 (21 residues), see Phobius details amino acids 129 to 149 (21 residues), see Phobius details amino acids 154 to 173 (20 residues), see Phobius details amino acids 178 to 196 (19 residues), see Phobius details PF12860: PAS_7" amino acids 225 to 335 (111 residues), 66.1 bits, see alignment E=4.7e-22 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 340 to 503 (164 residues), 140.8 bits, see alignment E=3.5e-45 PF00990: GGDEF" amino acids 342 to 498 (157 residues), 145.2 bits, see alignment E=2.3e-46

Best Hits

KEGG orthology group: None (inferred from 92% identity to bph:Bphy_6413)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (505 amino acids)

>QEN71_RS33235 sensor domain-containing diguanylate cyclase (Paraburkholderia sabiae LMG 24235)
MSEKASLYDSLLATPTPEKGVISPSVRAALMSALFDNAWPLFLSGMSSVFVAIVACFRLH
QSWTALWLIADIAVLAARLGIVRIYVARSRVCAVHPAPWATRYAPVSLVACLLLGLGTAA
CFLSPDKELATLAIMVAAGILGGIASRNAALPRLAIAQIFLGTVPIGIGALIAPQSGAWI
LVPPLIAYNAAMVSVVQRHYKGLVALMTAEQRHAELAARFDAALAYMPHGLCTVDGTGNV
VIANRRTAELFGATVEMLKLNVPLPEFIGHVGIAQFGETLHKRLVEQCNAWLHDERTPMD
LELQDGRQLELTRNPVPDGSAVIIIEDVTQRRQTEAKILHLASHDSLTGLPNRRELRDRL
EQILRVSARDQGGACAMMYLDLDGFKQVNDRLGHCAGDEVLETVAARLSRVLRPGELVAR
LGGDEFAIIADHTTLPSVVALAQRVIRDIALPYHLSTGEAVSIGTSVGIALAANDDSVDG
LIRRADQALYSAKQAGRGTYRVSNA