Protein Info for QEN71_RS25380 in Paraburkholderia sabiae LMG 24235

Annotation: urease subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00449: Urease_alpha
  • amino acids 4 to 120 (117 residues), 188 bits, E=9.6e-60
• TIGR01792: urease, alpha subunit
  • amino acids 5 to 568 (564 residues), 997 bits, E=1.4e-304
• PF01979: Amidohydro_1
  • amino acids 126 to 454 (329 residues), 284 bits, E=2.9e-88

Best Hits

Swiss-Prot: 93% identical to URE1_BURCM: Urease subunit alpha (ureC) from Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)

KEGG orthology group: K01428, urease subunit alpha [EC: 3.5.1.5] (inferred from 99% identity to bph:Bphy_2260)

MetaCyc: 74% identical to urease alpha subunit (Sinorhizobium meliloti Rm2011)
Urease. [EC: 3.5.1.5]

Predicted SEED Role

"Urease alpha subunit (EC 3.5.1.5)" in subsystem Urea decomposition (EC 3.5.1.5)

MetaCyc Pathways

• urea degradation II (1/1 steps found)
• superpathway of allantoin degradation in plants (4/8 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Atrazine degradation
• Purine metabolism
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.5

Use Curated BLAST to search for 3.5.1.5

Protein Sequence (568 amino acids)

>QEN71_RS25380 urease subunit alpha (Paraburkholderia sabiae LMG 24235)
MTLRIGRRAYAEMFGPTTGDRVRLADTDLLIEVERDYTIYGEEVKFGGGKVIRDGMGQSQ
RVAADVVDTVVTNALILDHWGIVKADIGIKNGRIAAIGKAGNPDIQPGVTIAIGAATEVI
AGEGMIVTAGGIDTHIHFISPQQIDEALASGVTTMLGGGTGPATGTNATTCTPGPWHMER
MLQAADGYPMNLGFLGKGNVSQPQPALEQIAAGAIGLKLHEDWGTTPAAIDNCLSVADDT
DTQVAIHTDTLNEAGFVEATVAAFKGRTIHTYHTEGAGGGHAPDIIKVCGEANVLPSSTN
PTRPYTVNTLDEHLDMLMVCHHLDPSIAEDIAFAESRIRRETIAAEDILHDLGALSMISS
DSQAMGRVGEVIIRTWQTAHKMKVQRGALPEDNARNDNFRAKRYVAKYTINPALTHGIAH
EVGSIEPGKWADIVFWEPAFFGVKPALILKGGMIAMAQMGDPNASIPTPQPVHYREMFAT
RGGALGRTSLTFVSQMALDADVAGRYGLSKRIVAVKNCRSVTKAHMIHNAWRPSISVDPE
TYQVIADGQLLTCEPAKVLPMAQRYFLF