Protein Info for QEN71_RS25110 in Paraburkholderia sabiae LMG 24235

Annotation: threonine-phosphate decarboxylase CobD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01140: threonine-phosphate decarboxylase
  • amino acids 7 to 326 (320 residues), 351.8 bits, E=1.8e-109
• PF00155: Aminotran_1_2
  • amino acids 57 to 315 (259 residues), 102.6 bits, E=1.3e-33

Best Hits

KEGG orthology group: K02225, cobalamin biosynthetic protein CobC (inferred from 87% identity to bph:Bphy_2206)

Predicted SEED Role

"L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis (EC 4.1.1.81)

MetaCyc Pathways

• adenosylcobalamin biosynthesis II (aerobic) (31/33 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (31/36 steps found)
• superpathway of L-threonine metabolism (15/18 steps found)
• aminopropanol phosphate biosynthesis I (2/2 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.81

Protein Sequence (333 amino acids)

>QEN71_RS25110 threonine-phosphate decarboxylase CobD (Paraburkholderia sabiae LMG 24235)
MTQTIQHGGNLHEAAQRYGIPYDAWLDLSTGINPHGYPVPPVPADAWRRLPDSGDGFAER
AARYYGAPDASHVLPVAGSQAAIRALPMLLERGTVGIARLTYGEYAPAFARAGHRVMTLD
VTRAALPDNLKHVVVVNPNNPTAEHLNASTLLQWHAALNERGGTLIVDEAFADALPSQSI
AAHTHREGVVVLRSPGKFFGLAGVRAGFVLACPRLLEALDETLGAWTVSGPARHAVSAAF
ADTAWQENMRAQLEHESSRLVALLNAHRFTVHSTPLFAWIADTRAAQLHHALAAQGVWTR
FFAAPASVRFGLPATESEWTRLEAALHHAMTTL