Protein Info for QEN71_RS23495 in Paraburkholderia sabiae LMG 24235

Annotation: imidazolonepropionase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 404 TIGR01224: imidazolonepropionase" amino acids 22 to 398 (377 residues), 488.4 bits, see alignment E=6.5e-151 PF01979: Amidohydro_1" amino acids 58 to 398 (341 residues), 71.8 bits, see alignment E=6.4e-24 PF07969: Amidohydro_3" amino acids 108 to 400 (293 residues), 57.3 bits, see alignment E=2.1e-19

Best Hits

Swiss-Prot: 95% identical to HUTI_PARP8: Imidazolonepropionase (hutI) from Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)

KEGG orthology group: K01468, imidazolonepropionase [EC: 3.5.2.7] (inferred from 95% identity to bph:Bphy_1810)

MetaCyc: 65% identical to imidazolonepropionase (Pseudomonas fluorescens)
Imidazolonepropionase. [EC: 3.5.2.7]

Predicted SEED Role

"Imidazolonepropionase (EC 3.5.2.7)" in subsystem Histidine Degradation (EC 3.5.2.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (404 amino acids)

>QEN71_RS23495 imidazolonepropionase (Paraburkholderia sabiae LMG 24235)
MKQTVWNHLKLCPQGDPNQTIDDAAIAVENGHIAWLGAARELPTQYAAWPREDLGGAWVT
PGLVDCHTHLVYGGQRADEFAQRLAGVSYEEIAKQGGGIVSTVRATRAADEASLFAQSAA
RLEAMLAEGVTAIEIKSGYGLDLQSERKMLRVARQLGERYPVTVYTTFLGAHALPPEFAG
RADDYIDEVCERMLPALADEGLVDAVDVFCERIGFSLEQSERVFNAAARRGLPVKMHAEQ
LSNAGGTALAARHRALSADHLEFLDEAGVVAMKESGTVAVLLPGAFYFIRETQLPPVDLL
RRYGVPIAISTDSNPGTSPATSLPLMMNMATTLFRMTVPEVLQGVTRHAAQALGKADTHG
TLAVGRAADFAVWSVQSLAELAYWIGRPLCERVVRGGETVFTRN