Protein Info for QEN71_RS21845 in Paraburkholderia sabiae LMG 24235

Annotation: NADP-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF16884: ADH_N_2
  • amino acids 6 to 113 (108 residues), 139.1 bits, E=7.5e-45
• PF00107: ADH_zinc_N
  • amino acids 158 to 288 (131 residues), 73.5 bits, E=2.5e-24
• PF13602: ADH_zinc_N_2
  • amino acids 191 to 326 (136 residues), 35.3 bits, E=3.4e-12

Best Hits

Swiss-Prot: 48% identical to CURA_ECOLI: NADPH-dependent curcumin reductase (curA) from Escherichia coli (strain K12)

KEGG orthology group: K07119, (no description) (inferred from 93% identity to bph:Bphy_1037)

MetaCyc: 48% identical to NADPH-dependent curcumin/dihydrocurcumin reductase (Escherichia coli K-12 substr. MG1655)
RXN0-6676; RXN0-6677

Predicted SEED Role

"Putative oxidoreductase YncB"

MetaCyc Pathways

• curcumin degradation (2/2 steps found)

Protein Sequence (332 amino acids)

>QEN71_RS21845 NADP-dependent oxidoreductase (Paraburkholderia sabiae LMG 24235)
MSQVNRQILLASRPQGAASADNFKLVDTPLAPLADGQVRVRNHYLSLDPYMRGRMSDAKS
YAAPQPLNEVMIGGTAGEVVESNNAAFKPGDKVVGMFGWQEFGTSDGKGLQKVDDTHVPL
SAYLGPVGMPGVTAWYGLNRIIAPKAGETVVVSAASGAVGSVVGQLAKLAGARAVGIAGG
AEKCRYVVETLGFDACVDYKTGNLYQDLKAATPDGIDGCFENVGGEGFDSTLARMNAHGR
IALCGFIAGYDGEPLPLKHPALMLTQRLLVQGFIVSEHMDVWPGALKELGGLVAQKKLHY
RETIAQGLENAPEAFLGMLKGRNFGKQLVKLI