Protein Info for QEN71_RS20195 in Paraburkholderia sabiae LMG 24235

Annotation: aldehyde dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 41 to 488 (448 residues), 523.3 bits, E=7.4e-161
  • amino acids 546 to 764 (219 residues), 136.2 bits, E=1.9e-43
• PF05893: LuxC
  • amino acids 145 to 322 (178 residues), 26.6 bits, E=4.3e-10
• PF07368: DUF1487
  • amino acids 273 to 456 (184 residues), 28.3 bits, E=1.9e-10

Best Hits

KEGG orthology group: K00128, aldehyde dehydrogenase (NAD+) [EC: 1.2.1.3] (inferred from 94% identity to bph:Bphy_4653)

Predicted SEED Role

"Aldehyde dehydrogenase (EC 1.2.1.3)" in subsystem Entner-Doudoroff Pathway or Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate (EC 1.2.1.3)

MetaCyc Pathways

• superpathway of glycol metabolism and degradation (7/7 steps found)
• ethanol degradation II (3/3 steps found)
• ethanol degradation IV (3/3 steps found)
• ethylene glycol degradation (2/2 steps found)
• putrescine degradation V (2/2 steps found)
• superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (6/8 steps found)
• phytol degradation (3/4 steps found)
• ethanol degradation III (2/3 steps found)
• hypotaurine degradation (2/3 steps found)
• putrescine degradation IV (2/3 steps found)
• putrescine degradation I (1/2 steps found)
• Entner-Doudoroff pathway II (non-phosphorylative) (6/9 steps found)
• mitochondrial NADPH production (yeast) (3/5 steps found)
• octane oxidation (3/5 steps found)
• superpathway of ornithine degradation (5/8 steps found)
• D-arabinose degradation II (2/4 steps found)
• L-tryptophan degradation X (mammalian, via tryptamine) (2/4 steps found)
• fatty acid α-oxidation I (plants) (2/4 steps found)
• histamine degradation (1/3 steps found)
• 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
• superpathway of L-arginine and L-ornithine degradation (8/13 steps found)
• dopamine degradation (2/5 steps found)
• aromatic biogenic amine degradation (bacteria) (4/8 steps found)
• putrescine degradation III (1/4 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (6/11 steps found)
• serotonin degradation (3/7 steps found)
• ceramide degradation by α-oxidation (2/7 steps found)
• sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
• alkane oxidation (1/6 steps found)
• limonene degradation IV (anaerobic) (1/7 steps found)
• noradrenaline and adrenaline degradation (4/13 steps found)
• superpathway of pentose and pentitol degradation (23/42 steps found)
• ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)

KEGG Metabolic Maps

• 1,2-Dichloroethane degradation
• 3-Chloroacrylic acid degradation
• Arginine and proline metabolism
• Ascorbate and aldarate metabolism
• Butanoate metabolism
• Fatty acid metabolism
• Glycerolipid metabolism
• Glycolysis / Gluconeogenesis
• Histidine metabolism
• Limonene and pinene degradation
• Lysine degradation
• Propanoate metabolism
• Pyruvate metabolism
• Tryptophan metabolism
• Urea cycle and metabolism of amino groups
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.3

Use Curated BLAST to search for 1.2.1.3

Protein Sequence (798 amino acids)

>QEN71_RS20195 aldehyde dehydrogenase family protein (Paraburkholderia sabiae LMG 24235)
MSVAEYFSSMEYGPAPEDDQPARAWLAQHDATFGHFVDGGWRAPAAGERFASHEPATGEF
LAQIAQGDAADIDAAVAAARAAQPAWFALGGAGRARHLYALSRMVQRHSRLFAVLEALDN
GKPIRETRDIDIPLVSRHFLHHAGWAQLQDSEFKDFAPLGVIGQIVPWNFPLLMLAWKIA
PAIATGNCVVLKPAEYTPLTALLFAELAQRAGLPKGVLNVVTGDGRTGAALVEHPGVDKI
AFTGSTEVGRMIRAATAGTGKSLTLELGGKSPFIVFDDADLDGAVEGVVDAIWFNQGQVC
CAGSRLLVQEGVAARFIDKLKRRMATLRVGPSLDKSIDIGAIVDKMQLERIASLVEAGRR
EGCEIYQSAEANVPSDGCFYPPTLVTGVAPASTLAQEEIFGPVLVTMTFRTPDEAVALAN
NTRYGLAASIWSETIGRALDIAPRLACGVVWVNATNLFDAAVGFGGYRESGYGREGGREG
LYEYVKPKAWLAREERRPVHRVTSSSTVHDVQEGADVFAIDRTAKLFIAGKQARPDSGYT
LPVYGADGVVVGEVGDGNRKDIRNAVAAARGASKWSQATAHNRAQVIYYLAENLAVRAQE
FAHQLVKRTGVSEAEARREVDASVTRLFTYAAWADKFDGAVHAPPLRCVALAMNEPLGVI
GVACPDEAPLLSFVSLIGPALAMGNRVVVLPSSSSPLTVTDFYQVVETSDVPAGVLNIVT
GERGALLSALAKHDDVDALWCFGSAKDSALAERESVGNLKRTFVDHGRAFDWFDTSSEGP
AFLRHATQVKNIWIPYGD