Protein Info for QEN71_RS16540 in Paraburkholderia sabiae LMG 24235

Annotation: L-threonine 3-dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 342 TIGR00692: L-threonine 3-dehydrogenase" amino acids 3 to 340 (338 residues), 543.7 bits, see alignment E=7.9e-168 PF08240: ADH_N" amino acids 26 to 134 (109 residues), 112.2 bits, see alignment E=1.7e-36 PF16912: Glu_dehyd_C" amino acids 154 to 327 (174 residues), 43.6 bits, see alignment E=3.8e-15 PF00107: ADH_zinc_N" amino acids 174 to 303 (130 residues), 107.3 bits, see alignment E=8.4e-35

Best Hits

Swiss-Prot: 98% identical to TDH_PARP8: L-threonine 3-dehydrogenase (tdh) from Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)

KEGG orthology group: K00060, threonine 3-dehydrogenase [EC: 1.1.1.103] (inferred from 98% identity to bph:Bphy_4160)

MetaCyc: 77% identical to threonine dehydrogenase (Escherichia coli K-12 substr. MG1655)
L-threonine 3-dehydrogenase. [EC: 1.1.1.103]

Predicted SEED Role

"L-threonine 3-dehydrogenase (EC 1.1.1.103)" in subsystem Glycine Biosynthesis or Threonine degradation (EC 1.1.1.103)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.103

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (342 amino acids)

>QEN71_RS16540 L-threonine 3-dehydrogenase (Paraburkholderia sabiae LMG 24235)
MKALAKLERATGLTLTDVKKPEVGHNDVMIRITRTAICGTDIHIWKWDDWAQKTIPVPMH
VGHEYVGEIVEMGQEVRGFSIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGA
FAEYLVIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSFNLVGEDVLITGAGPIGIMAV
AIAKHVGARNVVITDVNDYRLELARKMGATRAVNVSRESLRDVMNDLHMTEGFDVGLEMS
GVPSAFTSMLEAMNHGGKIALLGIPPAQTAIDWTQVIFKGLEIKGIYGREMFETWYKMVA
MLQSGLDLSPILTHRFAVDDFEKAFATMLSGESGKVILDWTV