Protein Info for QEN71_RS15355 in Paraburkholderia sabiae LMG 24235

Annotation: cytochrome o ubiquinol oxidase subunit IV

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02847: cytochrome o ubiquinol oxidase subunit IV
  • amino acids 17 to 112 (96 residues), 114.3 bits, E=1.5e-37
• PF03626: COX4_pro
  • amino acids 24 to 97 (74 residues), 56.6 bits, E=1.4e-19

Best Hits

Swiss-Prot: 51% identical to CYOD_PSEAE: Cytochrome bo(3) ubiquinol oxidase subunit 4 (cyoD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K02300, cytochrome o ubiquinol oxidase operon protein cyoD (inferred from 94% identity to bph:Bphy_3971)

MetaCyc: 46% identical to cytochrome bo3 subunit 4 (Escherichia coli K-12 substr. MG1655)
RXN-21817 [EC: 7.1.1.3]

Predicted SEED Role

"Cytochrome O ubiquinol oxidase subunit IV (EC 1.10.3.-)" in subsystem Terminal cytochrome O ubiquinol oxidase or Terminal cytochrome oxidases (EC 1.10.3.-)

MetaCyc Pathways

• NADH to cytochrome bo oxidase electron transfer I (2/2 steps found)
• glycerol-3-phosphate to cytochrome bo oxidase electron transfer (2/2 steps found)
• pyruvate to cytochrome bo oxidase electron transfer (2/2 steps found)
• succinate to cytochrome bo oxidase electron transfer (2/2 steps found)
• D-lactate to cytochrome bo oxidase electron transfer (1/2 steps found)
• NADH to cytochrome bo oxidase electron transfer II (1/2 steps found)
• proline to cytochrome bo oxidase electron transfer (1/2 steps found)

Isozymes

Compare fitness of predicted isozymes for: 1.10.3.-

Use Curated BLAST to search for 1.10.3.- or 7.1.1.3

Protein Sequence (114 amino acids)

>QEN71_RS15355 cytochrome o ubiquinol oxidase subunit IV (Paraburkholderia sabiae LMG 24235)
MSSHSHSSHSAHGDESHGSFGSYTIGFVLSVILTAAAFGVVLAGWLTGTQALYAIAGLGL
VQIIVHLVFFLHMNTSSGQRWNVTAFAFTVLTAVIVIGGTLWVMHNVSMNMMSR