Protein Info for QEN71_RS14425 in Paraburkholderia sabiae LMG 24235
Annotation: aldehyde dehydrogenase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 50% identical to ALDH4_BACSU: Putative aldehyde dehydrogenase DhaS (dhaS) from Bacillus subtilis (strain 168)
KEGG orthology group: K00146, phenylacetaldehyde dehydrogenase [EC: 1.2.1.39] (inferred from 94% identity to bph:Bphy_3815)MetaCyc: 60% identical to phenylacetaldehyde dehydrogenase monomer (Pseudomonas putida U)
Phenylacetaldehyde dehydrogenase. [EC: 1.2.1.39]
Predicted SEED Role
"Aldehyde dehydrogenase in Methylamine utilization cluster"
MetaCyc Pathways
- superpathway of phenylethylamine degradation (8/11 steps found)
- L-phenylalanine degradation II (anaerobic) (2/3 steps found)
- phenylethanol degradation (1/2 steps found)
- phenylethylamine degradation I (1/2 steps found)
- phenylethylamine degradation II (1/2 steps found)
- styrene degradation (1/3 steps found)
- L-phenylalanine degradation IV (mammalian, via side chain) (5/9 steps found)
- anaerobic aromatic compound degradation (Thauera aromatica) (5/27 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.39
Use Curated BLAST to search for 1.2.1.39
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (501 amino acids)
>QEN71_RS14425 aldehyde dehydrogenase family protein (Paraburkholderia sabiae LMG 24235) METKNTFPLLDATQAFLAKPKRMLIGGEWTDATSGCAIDVVNPADGSVLTRVPEANEHDV QQAVAAARRAFDAGPWRSMKTTDRERLLLKLADLVEANARELAEIESLDNGKPVMVAQGL DVSMTAQCFRYMAGWATKIEGSVIDAGMPYMPDSEVFSYTRKEPVGVVGAIIPWNFPLLM AAWKLAPALATGCTVVLKPAEDTPLSALRLGELIREAGYPEGVVNIVTGYGHTAGAALSR DPRIDKIAFTGSTQTGKLIGHAALDNMTRMSLELGGKSPVIVLPDVDIDKAAQGVANAIF FNSGQVCTAGSRVYIHNQVFDKVIDGVAQIAKSLKVGAGMDPSTLIGPLVSVKQRDRVCG YIDSGFAEGARAAAGGKMLDKPGFFVEPTVMVDTNHTMRVVREEIFGPVLVAMPFDDIDT AVQLANDTPYGLGASIWSNDMSAVHKLIPRIAAGTVWVNCHSLLDNAMPFGGMKQSGFGR ELGRAVIEQYTESKSVMINYA