Protein Info for QEN71_RS13895 in Paraburkholderia sabiae LMG 24235

Annotation: DHA2 family efflux MFS transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 478 transmembrane" amino acids 12 to 35 (24 residues), see Phobius details amino acids 48 to 71 (24 residues), see Phobius details amino acids 78 to 99 (22 residues), see Phobius details amino acids 106 to 125 (20 residues), see Phobius details amino acids 137 to 159 (23 residues), see Phobius details amino acids 166 to 186 (21 residues), see Phobius details amino acids 198 to 216 (19 residues), see Phobius details amino acids 228 to 247 (20 residues), see Phobius details amino acids 265 to 287 (23 residues), see Phobius details amino acids 291 to 312 (22 residues), see Phobius details amino acids 332 to 351 (20 residues), see Phobius details amino acids 357 to 383 (27 residues), see Phobius details amino acids 395 to 418 (24 residues), see Phobius details amino acids 444 to 463 (20 residues), see Phobius details TIGR00711: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family" amino acids 16 to 417 (402 residues), 243.7 bits, see alignment E=1.9e-76 PF06609: TRI12" amino acids 17 to 192 (176 residues), 27.4 bits, see alignment E=1.3e-10 PF07690: MFS_1" amino acids 18 to 408 (391 residues), 182.9 bits, see alignment E=8.7e-58

Best Hits

Swiss-Prot: 36% identical to HSRA_ECOLI: Probable transport protein HsrA (hsrA) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 91% identity to bph:Bphy_3744)

Predicted SEED Role

"Permeases of the major facilitator superfamily"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (478 amino acids)

>QEN71_RS13895 DHA2 family efflux MFS transporter permease subunit (Paraburkholderia sabiae LMG 24235)
MKDSSRSGSLGPLPYVVAATFFMEYLDTTIIATALPQMAQSFGTSPNALSLGMSAYMIAL
AIFIPASGWVADRFGSRSVFFSAIVTFTLASLLCGVSQNVVEFTAARVLQGIGGALMVPV
GRLTVVRSIDKKQLMQAISTITWPGIVAPVVGPPIGGFITTYASWRWIFLLNLPVCLVVL
IAVLKWVPNLRSAERRPFDALGLVLSAMTLTAILYGADMASQPDTNPFVGLGVVVIGLAI
GCVAFYQARRQRHPLIDVSTLKIPTFSVTVVTGTITRIGIGAVPYLMPLLFQIGFGLSAF
KSGLLLLVSATGNLGMKALTTRILTRYGFRRVAIAASTICGMFTIVCGMLTPDSPLAWIL
LVVFVYGLGRSLQFSTLATLAYADVPSEQTSAANTLWNAAAQMSIGLGIAFGAVALRAAS
AVNGNGNANGNGGDHAHVFTLGDFRFAFLCAGVVTIASVYGYVKLARDAGNRLRAASN