Protein Info for QEN71_RS13225 in Paraburkholderia sabiae LMG 24235

Annotation: oxalyl-CoA decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 579 transmembrane" amino acids 433 to 449 (17 residues), see Phobius details TIGR03254: oxalyl-CoA decarboxylase" amino acids 20 to 573 (554 residues), 1014.2 bits, see alignment E=0 PF02776: TPP_enzyme_N" amino acids 23 to 137 (115 residues), 107.6 bits, see alignment E=5.3e-35 PF00205: TPP_enzyme_M" amino acids 214 to 342 (129 residues), 114.1 bits, see alignment E=6.3e-37 PF02775: TPP_enzyme_C" amino acids 412 to 553 (142 residues), 98.8 bits, see alignment E=4e-32

Best Hits

Swiss-Prot: 63% identical to OXC_ECO57: Oxalyl-CoA decarboxylase (oxc) from Escherichia coli O157:H7

KEGG orthology group: K01577, oxalyl-CoA decarboxylase [EC: 4.1.1.8] (inferred from 98% identity to bph:Bphy_3618)

MetaCyc: 63% identical to oxalyl-CoA decarboxylase (Escherichia coli K-12 substr. MG1655)
Oxalyl-CoA decarboxylase. [EC: 4.1.1.8]

Predicted SEED Role

"Oxalyl-CoA decarboxylase (EC 4.1.1.8)" in subsystem Alkaloid biosynthesis from L-lysine (EC 4.1.1.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (579 amino acids)

>QEN71_RS13225 oxalyl-CoA decarboxylase (Paraburkholderia sabiae LMG 24235)
MADVLEIRPQESAEENAQQLTDGFHLVIDALKANDIDTIFGLVGIPITDLARLAQAEGMR
FIGFRHEQHAGHAAAIAGYMTQKPGICLTVSAPGFLNGLTALANATTNCFPMILISGSSE
REIVDLQQGDYEEMDQLNAAKPYAKAAYRVLHAEDIGIGLARAIRAAVSGRPGGVYLDLP
AKLLSQTIDAVKAKQSIVRVIDAAPRQLPAPDSVKRAIDLLKGAKRPLVLLGKGASYSQA
DKEIRAFIEKTGIPYLPMSMAKGLLPDTHEQSASAARSFVLAESDVVVLVGARLNWLLSH
GKGKTWGKPKQFVQIDISAQEMDSNVAIAAPLVGDIGSCVASLLDQVGDDFPQPPKEWID
AVNEKKNTNLQKMAATLAKNPSPMNFHSALRVLRDIVKANPDINVVNEGANTLDYARAII
DMYQPRKRFDSGTWGVMGIGMGFAIGAAVTSGKQVLAIEGDSAFGFSGMELETICRYDLP
VCTIIFNNNGVYRGTDVNPTGGKDVAPTVFVKDARYDKMIEAFGGIGYNVTTPEELEKAV
KESIASGKPTLINAVIDEAAGTESGRLTNLNPQSAAMKK