Protein Info for QEN71_RS12430 in Paraburkholderia sabiae LMG 24235

Annotation: NCS2 family permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 433 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 52 to 73 (22 residues), see Phobius details amino acids 98 to 121 (24 residues), see Phobius details amino acids 133 to 153 (21 residues), see Phobius details amino acids 173 to 190 (18 residues), see Phobius details amino acids 196 to 216 (21 residues), see Phobius details amino acids 236 to 258 (23 residues), see Phobius details amino acids 283 to 305 (23 residues), see Phobius details amino acids 317 to 337 (21 residues), see Phobius details amino acids 342 to 360 (19 residues), see Phobius details amino acids 379 to 402 (24 residues), see Phobius details amino acids 414 to 431 (18 residues), see Phobius details PF00860: Xan_ur_permease" amino acids 20 to 390 (371 residues), 187.7 bits, see alignment E=1.5e-59

Best Hits

Swiss-Prot: 53% identical to Y326_METJA: Putative permease MJ0326 (MJ0326) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K06901, putative MFS transporter, AGZA family, xanthine/uracil permease (inferred from 97% identity to bph:Bphy_5121)

MetaCyc: 49% identical to adenine:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-447

Predicted SEED Role

"Xanthine/uracil/thiamine/ascorbate permease family protein" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (433 amino acids)

>QEN71_RS12430 NCS2 family permease (Paraburkholderia sabiae LMG 24235)
MDSVKRYFGFDEAGTTLRVEVLAGITTFLTMAYIIFVNPAILGDAGMPKDSVFVATCLVA
ALASLIMGFYANYPIACAPGMGLNAYFAYTVVKGLGFSWQAALGAVFISGCLFLVVTLLR
VREVIVTGIPHSIRVAITGGIGLFLAIISLKTAGIVTGNPATLVTLGNLHDPHVVLAIIG
FFAIVTLDFLRVRGAILIGIVGVTILSFFFGGNQFHGVVSMPPSISPTLFQLDIKAALST
GVLNVILVFFLVELFDATGTLMGVANRAGLLVHGKMHRLNRALLADSTAILAGSVLGTSS
TTAYIESASGVQAGGRTGVTAITVAVLFLLALFFAPLAGVVPGYATAPALLYVSCLMLRE
MADLPWDDATEVVPAALTALMMPFTYSIANGVAFGFISYAGLKLLTGRARQVKLVVWVIA
AVFLFRFFYLGSE