Protein Info for QEN71_RS11435 in Paraburkholderia sabiae LMG 24235

Annotation: mannitol dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08125: Mannitol_dh_C
  • amino acids 198 to 353 (156 residues), 83.8 bits, E=7.1e-28

Best Hits

KEGG orthology group: K00041, tagaturonate reductase [EC: 1.1.1.58] (inferred from 81% identity to bpy:Bphyt_5477)

Predicted SEED Role

"Altronate oxidoreductase (EC 1.1.1.58)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 1.1.1.58)

MetaCyc Pathways

• D-galacturonate degradation I (4/5 steps found)
• superpathway of hexuronide and hexuronate degradation (5/10 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (19/31 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.58

Protein Sequence (386 amino acids)

>QEN71_RS11435 mannitol dehydrogenase family protein (Paraburkholderia sabiae LMG 24235)
MSEPILQFGTSRFLLAHVALFVSEALERGDAIGGISVVQTTSNPSSRARVAALNETGSYP
VKIRGRERGAIVDKVVHGRAIGAAWIADRDWATIRSAVIHDVRAIVSNTGDTGYCLDPRD
TAAVLASDGPVPHSYPAKLLALLHARWRERPDSGVSVFPCELVASNGDTLRDLVIGLAER
WEAPASFIAYLSQRCVWINSLVDRIVSEPIEPVGAVAEPYALWAIERRPGMDLPCTHENI
VVTEDLRSYEQLKLFFLNLGHTWLADQWLAHGRSATETVVEAMNDAVLRDGLEAVWAEEV
LPVFDAMGLRNRAEQYAASVRERFLNPYLRHRIADIASNHPEKVRRRILPLIDLADSLSV
PPLQTRLRVTLARHEAMPSAQKADAS