Protein Info for QEN71_RS08175 in Paraburkholderia sabiae LMG 24235

Annotation: betaine-aldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01804: betaine-aldehyde dehydrogenase
  • amino acids 10 to 476 (467 residues), 726.7 bits, E=4.8e-223
• PF00171: Aldedh
  • amino acids 15 to 478 (464 residues), 603.2 bits, E=1.4e-185

Best Hits

Swiss-Prot: 95% identical to BETB_PARP8: NAD/NADP-dependent betaine aldehyde dehydrogenase (betB) from Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)

KEGG orthology group: K00130, betaine-aldehyde dehydrogenase [EC: 1.2.1.8] (inferred from 95% identity to bph:Bphy_3309)

MetaCyc: 70% identical to betaine aldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Betaine-aldehyde dehydrogenase. [EC: 1.2.1.8]

Predicted SEED Role

"Betaine aldehyde dehydrogenase (EC 1.2.1.8)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.2.1.8)

MetaCyc Pathways

• choline-O-sulfate degradation (3/3 steps found)
• glycine betaine biosynthesis III (plants) (3/3 steps found)
• choline degradation I (2/2 steps found)
• glycine betaine biosynthesis I (Gram-negative bacteria) (2/2 steps found)
• glycine betaine biosynthesis II (Gram-positive bacteria) (2/2 steps found)
• β-alanine biosynthesis I (1/2 steps found)
• β-alanine biosynthesis IV (1/2 steps found)
• choline degradation IV (2/4 steps found)
• dimethylsulfoniopropanoate biosynthesis I (Wollastonia) (1/3 steps found)
• dimethylsulfoniopropanoate biosynthesis II (Spartina) (1/4 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.8

Use Curated BLAST to search for 1.2.1.8

Protein Sequence (489 amino acids)

>QEN71_RS08175 betaine-aldehyde dehydrogenase (Paraburkholderia sabiae LMG 24235)
MPAYGLQRLYIGGEYVDATSGATFDTFDPATGELLATVQQASEADIERAVHSAREGQRAW
AAMTAMQRSRILRRAVELLRARNDELAELEMRDTGKPIAETRAVDIVTGADVIEYYAGLA
TAIEGQQIPLRPESFVYTRREPLGVTAGIGAWNYPIQIACWKSAPALAAGNAMIFKPSEV
TPLSASKLAEIYLEAGVPAGVFNVVQGDGRVGAMLSAHPGIAKISFTGGVETGKKVMSMA
GGSSLKEVTMELGGKSPLIVFDDADLDRAADIAVTANFFSAGQVCTNGTRVFVHQSVQQA
FEARVIERVKRIRVGKPSDPSTNFGPLASAAQLDKVLGYIDSGKREGARLVAGGARIVDG
EFSKGQYVQPTVFADCRDDMKIVREEIFGPVMSILTFADEDEAIARANDTIYGLAAGVVT
ENLSRAHRAIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGITTLEHYTRIKSVQV
ELGPYQPVF