Protein Info for QEN71_RS05120 in Paraburkholderia sabiae LMG 24235

Annotation: propionate--CoA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02316: propionate--CoA ligase
  • amino acids 3 to 628 (626 residues), 1095.1 bits, E=0
• PF16177: ACAS_N
  • amino acids 4 to 58 (55 residues), 85.5 bits, 2.6e-28
• PF00501: AMP-binding
  • amino acids 61 to 444 (384 residues), 256 bits, E=8.3e-80
• PF13193: AMP-binding_C
  • amino acids 511 to 594 (84 residues), 86.1 bits, E=3.9e-28

Best Hits

KEGG orthology group: K01908, propionyl-CoA synthetase [EC: 6.2.1.17] (inferred from 96% identity to bph:Bphy_1588)

Predicted SEED Role

"Propionate--CoA ligase (EC 6.2.1.17)" in subsystem Methylcitrate cycle or Propionate-CoA to Succinate Module (EC 6.2.1.17)

MetaCyc Pathways

• 2-methylcitrate cycle I (5/5 steps found)
• acrylate degradation II (3/3 steps found)
• superpathway of coenzyme A biosynthesis II (plants) (8/10 steps found)
• 2-methylcitrate cycle II (5/6 steps found)
• β-alanine biosynthesis II (4/6 steps found)
• L-isoleucine biosynthesis IV (4/6 steps found)

KEGG Metabolic Maps

• Propanoate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.17

Protein Sequence (635 amino acids)

>QEN71_RS05120 propionate--CoA ligase (Paraburkholderia sabiae LMG 24235)
MTSYREFHRRSIESPEDFWREQATRIHWETKFDTVLDRSNPPFARWFVGGRTNLCHNAVD
RHLAERAQQNALVYVSTETGIERRYTYAELHAEVNRMAAVMRSLGVKRSDRVLIYLPMIP
EAVFAMLACARLGAIHSVVFGGFAAPNLAARIDDAKPALIVTADAGARAGKVIDYTPLVD
EAMSRATHKTPHVLLIDRQLTPERLNAPYLVAYEPLREQFFDAHVQCEWLESTEPSYVLY
TSGTTGKPKGVQRDVGGYAVALAASMEYIFEGKPGDTMFTASDVGWVVGHSYIVYAPLIA
GLTTVMYEGTPIRPDGGIWWRLVEQYKINLMFTAPTAIRVLKKQDPALLKQADLSSLRTL
FLAGEPLDEPTASWIADSLGKPVVDNFWQTETGWPILAIQRGVEALPQKLGSPGVPCYGY
DLTLRNEHTGEPCPAGEKGVITLGYPLPPGCMSTVWGDDARFVKTYWESVPNQQVYSTFD
WGIQDEDGYVTILGRTDDVINVAGHRLGTREIEEALSGHKAVAEVAVVGVTDAVKGQAAI
AFVVVRDAGAYESDDARAKLSAELCATVDRHLGAIARPAHVVLVSMLPKTRSGKLLRRAI
AALAEGRDPGDLPTIEDPSALQQIREAVAAALTSK