Protein Info for QEN71_RS02990 in Paraburkholderia sabiae LMG 24235

Annotation: multicopper oxidase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 542 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF07732: Cu-oxidase_3" amino acids 121 to 216 (96 residues), 93.2 bits, see alignment E=1.8e-30 PF07731: Cu-oxidase_2" amino acids 434 to 541 (108 residues), 104.3 bits, see alignment E=7.2e-34

Best Hits

KEGG orthology group: K08100, bilirubin oxidase [EC: 1.3.3.5] (inferred from 67% identity to bac:BamMC406_2440)

Predicted SEED Role

"Multicopper oxidase" in subsystem Copper homeostasis

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (542 amino acids)

>QEN71_RS02990 multicopper oxidase family protein (Paraburkholderia sabiae LMG 24235)
MIRREFLARTLSVAVASLFARNVSAQHSMHDMHGMSDMDDMPGMSSSHSSHANQHAAQGT
PKLAPETAIPSGAPLAALRTLRNESSEPGVFRATLVAQPVRRQLMPGHPTALWLYGDAAQ
GPIVGPLIDVREGDTVEIRFVNHLPQPSTIHWHGLPVPPDQDGNPMNPVAPGETHVYRFT
LPPGSAGTYWYHPHPHMMSAEQVFRGLAGPIVVRAADDPLAAFPERHLFFTDLKLASDAS
VAPNDMMDWMNGREGQFVLVNGARRPRIDVAQDERWRLWNGGNARYLRLSLGGNRTFTQV
GTDGGLLDKPRDGLTELLLAPGERAEIVVRAGAQASTAVLTAAAYDRRKMTMTEGKSLPA
DPAKPLADVRFTPSSTAAARTVPPTLRPIAPLLSSTDSAADKAPRKSVVFSEEMDMTAMH
RPGATMSALPPGMQFMINGARFDSSRIALTSRRGEVEVWSIENRTDMDHPFHLHGTQFQV
IRRERGGVAVPEPYLAWRDTVNVQPGETVRIATVQRDAGERMFHCHILEHEDLGMMATLK
VV