Protein Info for QEN71_RS02045 in Paraburkholderia sabiae LMG 24235

Annotation: dihydroneopterin triphosphate diphosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00293: NUDIX
  • amino acids 9 to 144 (136 residues), 40.6 bits, E=1.3e-14

Best Hits

Swiss-Prot: 48% identical to NUDB_ECO57: Dihydroneopterin triphosphate diphosphatase (nudB) from Escherichia coli O157:H7

KEGG orthology group: K08310, dATP pyrophosphohydrolase [EC: 3.6.1.-] (inferred from 92% identity to bph:Bphy_0382)

MetaCyc: 48% identical to dihydroneopterin triphosphate diphosphatase (Escherichia coli K-12 substr. MG1655)
3.6.1.M7,3.6.1.9 [EC: 3.6.1.9, 3.6.1.M7]; H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN [EC: 3.6.1.9, 3.6.1.M7, 3.6.1.67]

Predicted SEED Role

"Dihydroneopterin triphosphate pyrophosphohydolase type 2" in subsystem Folate Biosynthesis or Queuosine-Archaeosine Biosynthesis

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
• superpathway of tetrahydrofolate biosynthesis and salvage (11/12 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (12/14 steps found)
• superpathway of tetrahydrofolate biosynthesis (9/10 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
• 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I (4/5 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis II (5/7 steps found)
• superpathway of chorismate metabolism (42/59 steps found)
• dZTP biosynthesis (3/5 steps found)
• pyrimidine deoxyribonucleotides dephosphorylation (1/3 steps found)
• tunicamycin biosynthesis (1/9 steps found)

KEGG Metabolic Maps

• Folate biosynthesis
• Lipopolysaccharide biosynthesis
• Nicotinate and nicotinamide metabolism
• Pantothenate and CoA biosynthesis
• Purine metabolism
• Riboflavin metabolism
• Starch and sucrose metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.-

Use Curated BLAST to search for 3.6.1.- or 3.6.1.67 or 3.6.1.9 or 3.6.1.M7

Protein Sequence (158 amino acids)

>QEN71_RS02045 dihydroneopterin triphosphate diphosphatase (Paraburkholderia sabiae LMG 24235)
MPKPPKIPESVLVVIHTPDLDVLLIERADREAFWQSVTGSKEHIDEPLGETAIREVAEET
GIVVGSEAVPREALVDWQHHIEFEIFPTWRHRYAEGVTHNTEHWFSLQVPQRLEVTLAPL
EHTAHLWLPWQEAAERCFSWSNRDAILQLPQRVKERCR