Protein Info for PP_4595 in Pseudomonas putida KT2440

Annotation: putative LRP-like transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 164 PF13412: HTH_24" amino acids 12 to 58 (47 residues), 66.4 bits, see alignment E=2.6e-22 PF13404: HTH_AsnC-type" amino acids 12 to 53 (42 residues), 63 bits, see alignment E=3.6e-21 PF01037: AsnC_trans_reg" amino acids 78 to 152 (75 residues), 85.1 bits, see alignment E=5.1e-28

Best Hits

Swiss-Prot: 57% identical to DECR_ECOLI: DNA-binding transcriptional activator DecR (decR) from Escherichia coli (strain K12)

KEGG orthology group: K05800, Lrp/AsnC family transcriptional regulator (inferred from 100% identity to ppu:PP_4595)

Predicted SEED Role

"Transcriptional regulator, AsnC family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q88E71 at UniProt or InterPro

Protein Sequence (164 amino acids)

>PP_4595 putative LRP-like transcriptional regulator (Pseudomonas putida KT2440)
MKYFPARPARDMDSFDQHILTLLQRDASISLKDLAEAVNLSTTPCWKRVKRLEEDGYILG
RVALLDPERLGLGLTVFVQLKTQRHDSAWLEQFAATVTGFEEVMECYRMSGDWDYMLRVV
VGDIAAYDRFYKKLITHTDGLSNITSSFAMEQMKYTTAYPVHRA