Protein Info for PP_4298 in Pseudomonas putida KT2440

Annotation: hydroxypyruvate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03234: hydroxypyruvate isomerase
  • amino acids 2 to 255 (254 residues), 405.8 bits, E=3.3e-126
• PF01261: AP_endonuc_2
  • amino acids 21 to 256 (236 residues), 184.8 bits, E=1.2e-58

Best Hits

Swiss-Prot: 58% identical to HYI_ECOLI: Hydroxypyruvate isomerase (hyi) from Escherichia coli (strain K12)

KEGG orthology group: K01816, hydroxypyruvate isomerase [EC: 5.3.1.22] (inferred from 99% identity to ppf:Pput_1571)

MetaCyc: 58% identical to hydroxypyruvate isomerase (Escherichia coli K-12 substr. MG1655)
Hydroxypyruvate isomerase. [EC: 5.3.1.22]

Predicted SEED Role

"Hydroxypyruvate isomerase (EC 5.3.1.22)" (EC 5.3.1.22)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.22

Sequence Analysis Tools

See Q88F02 at UniProt or InterPro

Protein Sequence (260 amino acids)

>PP_4298 hydroxypyruvate isomerase (Pseudomonas putida KT2440)
MPRFAANLSMLFTEQDFLARFKAAADAGFSGVEYLFPYDFSAADIKQQLEANGLTQVLFN
LPAGDWAKGERGITCHPDRIEEFRAGVDKAIEYAKVLGNTQVNALAGIRPQGPDCATVRK
TFVENLRYAADKLKGAGIRLVMEMINTRDIPGFYLNTTQQALEIQAEVGSDNLFLQYDIY
HMQIMEGDLARTMEANLKLINHIQLADNPGRNEPGTGEINYRFLFEHLDRIGYQGWVGAE
YKPLTTTEAGLGWLKTHNAI