Protein Info for PP_4219 in Pseudomonas putida KT2440

Annotation: non-ribosomal peptide synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 500 1000 1500 2000 2500 3000 3470 transmembrane" amino acids 282 to 301 (20 residues), see Phobius details amino acids 1340 to 1357 (18 residues), see Phobius details amino acids 3281 to 3298 (18 residues), see Phobius details PF00668: Condensation" amino acids 45 to 489 (445 residues), 374.8 bits, see alignment E=1.5e-115 amino acids 1105 to 1543 (439 residues), 371.6 bits, see alignment E=1.4e-114 amino acids 2177 to 2604 (428 residues), 258.3 bits, see alignment E=3.3e-80 PF00501: AMP-binding" amino acids 509 to 853 (345 residues), 305.3 bits, see alignment E=1.4e-94 amino acids 1564 to 1913 (350 residues), 295.4 bits, see alignment E=1.5e-91 amino acids 2625 to 2974 (350 residues), 264.3 bits, see alignment E=4e-82 TIGR01733: amino acid adenylation domain" amino acids 530 to 925 (396 residues), 437.8 bits, see alignment E=7.4e-135 amino acids 1585 to 1987 (403 residues), 458.8 bits, see alignment E=3.1e-141 amino acids 2645 to 3047 (403 residues), 400.1 bits, see alignment E=2e-123 PF13193: AMP-binding_C" amino acids 909 to 992 (84 residues), 36 bits, see alignment (E = 2.7e-12) amino acids 1971 to 2054 (84 residues), 41.4 bits, see alignment (E = 5.6e-14) amino acids 3031 to 3106 (76 residues), 44.2 bits, see alignment (E = 7.8e-15) PF00550: PP-binding" amino acids 1019 to 1083 (65 residues), 48.6 bits, see alignment (E = 1.9e-16) amino acids 2081 to 2144 (64 residues), 46.6 bits, see alignment (E = 8.4e-16) amino acids 3132 to 3194 (63 residues), 40.7 bits, see alignment (E = 6e-14) PF00975: Thioesterase" amino acids 3214 to 3334 (121 residues), 89.4 bits, see alignment (E = 1.1e-28)

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q88F79 at UniProt or InterPro

Protein Sequence (3470 amino acids)

>PP_4219 non-ribosomal peptide synthetase (Pseudomonas putida KT2440)
MQALLDSVESLSSRERKALAALLKQQGVNLYGVTRIFARDPADPTPVSYAQERQWFLWQL
DPASGAYNIGAALQLQGRLDIEGLRGACQALIQRHEVLRTTLRQDSDRVVQIIHPQMPFE
LLIEPLIGMSATSDALREHVEACIAKPFDLEQGPLLRLNLLPLGEDDHVLVLTVHHIAAD
GWSMPILINDLVQCYERLSQGQAPNLPALPVQYADYAIWQRNWMEAGEQARQLAYWKDTL
GGEQPVLSLPTNRSRPVAPSGRGARVGIEIDAVLLQSLKALANAQGVTLFMLLLASFQTL
LHRYSGQPQVRVGVPIANRNRSEVQGLIGFFVNTQVLKADFALHSRFIDVLQQVKETALQ
AQAHQDLPFEQLVEALQPERSMSHSPLFQVMFNHQAQAASDAHAQLSGLQVRGLEWDSRT
TQFDLTLDTREHADGLFASLTYATDLFDVSRIEQMARHWRNLLIQACQDPRKRVLELALL
EHDERERILGQWNQTQMAYPTKLGVYRLFEQQVCRTPDAVALRFGEQTLSYAELNRQANQ
LAHALRERGVGPEVLVGVAMPRGPRMLVGLLAIFKAGGAYVPLDPDYPAERLAYMIEDSG
LGLLLTEQAVLARLQVPATVASLCLDTDTACYASAAAEDLPLDVDADHPAYVIYTSGSTG
RPKGVTVRHGALVNFLTSMAVQPGIAASDRVLALTSLSFDIAGLELYLPLLHGASVVLLA
DQQNKDPFALLRVIEQQAVSVIQATPSTWRMLLDNAPPQALRGKRVISGGEALSSELAQR
LIDQAGHVWNLYGPTETTIWSGIEKVTDSRQVWLGKPIGNTTFHVLDAQFDAVPVGVSGE
LFIGGDGLARGYLKRPGLTAERFIPNPHGHGRLYRTGDLVRYRDDGVLEYMGRIDHQLKI
RGFRIELGEIEASLQGFGAVREVAVIDVDGPLGKQLAGYIVPYDASLLQADAEVQETLRL
ALKAHALKSMPDYMVPTHLVFIPRMPLTPNGKLDRKALPAPDLAAAQRPYQAPTSPLQQA
LAAIWADVLKVGQVGLSDSFFELGGHSLLASQMIGRVRQQLALEVPLRSVFEAQDLAGFA
ERVAAATTGAQLPAIAVVPRGEPLALSYAQQRQWVLWQLEPHSAAYNIASALHLRGALDV
AALQQAFQALVARHESLRTTFVQVDGEARQVIHAPEAQGACLRQADVDAVELQATVEQLA
REPFDLVNGPLIRVDLLRLEAQAHVLVMNLHHIITDGWSMAVLVNELVALYQGYRHGQAV
ELPALAVQYADYAAWQRQWLEASEQARQLAYWEAQLGGEQPVLELPTDYPRPAQPSRAGG
QLSLALDAPLVQALRRQAQAQGVTLFMLLLASFQTLLHRYSTQPDIRVGVPVANRTRGET
EGVVGFFVNTQVHKAEFHLRLRFVELLRQVRQTALDAQAHQDLPFEQLVAALKPDRILNQ
NPLFQVMFNHQAEAKGAPREVPGLQIEAVDWQVHSTQFDLALDTAEHADGMTAAFTFATE
LYDRQTIEQMARHWRNLLQAISRDANQVVAQLPMLDDLEQQCMLHDWNATAVAYPQARLV
HQLFEDQAQRHPQAPALIFADATLSYTELDQRANRLANKLREQGVGPEVLVGVAVERSLE
LVIGLMAVLKAGGAYVPLDPDYPSDRLAYMIEDSGIGLLLSQQALAERLPVPAAVRILCL
DQDAQWLAGYADTAPEVDVRLANLAYVIYTSGSTGRPKGAGNTHEALLNRLQWMQGAYGL
DASDTVLQKTPFSFDVSVWEFFWPLMTGARLAVALPGDHRDPQRLCQTIIDHQVSTLHFV
PSMLQAFMASAEVEQCRSVRRVVCSGEALPAVLAQQCRERLPHAGLYNLYGPTEAAIDVT
HWTCGDKQGFSVPIGQPIDNLRTHILEPDLLPAARGVNGELYLAGIGLARGYHGRPALTA
ERFVPDPFDEQGGRLYRTGDLARYRPDGVIDYAGRIDHQVKIRGLRIELGEIEARLAEHA
QVREAVVLAQDGPSGKQLVGYVVPMAAEQAEPGSEAGQRLREQLAHFLGQGLPDYMVPAH
LMLLANLPVTANGKLARNLLPAPDFNAARQVYVAPRTALEQQLASIWETVLNLPQVGMQD
NFFALGGDSIIAIQVVSQARQLGLDIAPRDLFLLQTIEQLAARVGQWQMVEQQSVALHSL
TEQQVQALPLEHAGVDGLYSLSPMQQGMLFLSLNGRPEDQLYINQLSVPVQGLVAERLRQ
AWETVVARHDVLRTGFLWQDLDEPLQYVMGQLPLPLRELDWRGRGDCAQALEALANEERE
RGFDLARPPLQRMLLVRLDDQRHQLIWTYHHILLDGWSTSQLMGEVLACYSGQTLDSVVP
YRNYIGWLRQQDPRHSETFWKQQLASLQEPTYLADAFASGERGSGHQALYSRFSVAQTET
FKAFAQSQRITLNTVVQGAWLLLLSRYSGQRSVSFGATVAGRPAALPGVQSMLGLFINTL
PVIHEVDPQAQVGQWLQQLQRINLELRDHEYTALGEIQRWAGRSGQPLFDSIIVFENQPL
DRTLREWKDDSLQFGDVGGSGLTDFPMDLMVIVEDQLIIEYMYLRQCFSEEAVAGIRANM
EALLQALSLDGQARLGNLGLLPGAPLRALTPPAQQAPLLVHERIAQWAQQQGDAVAVKVD
GQTLSFAELDRAANCLAHALIAEGVGPEVRVGVALQRTPQMIVALLAVLKAGAAYVPIDT
AYPAERLSYLMEDSGVALLVSQTAALAGLPKLANVHALNLDSFDPTQWPGHAPQVTLQGE
NLAYVIYTSGSTGKPKGVVVSHDALAMHCQAIGERYEMTPADCELLFMSFAFDGAHERWL
TALTHGGSVLLRGDELWTPEQTCQALHRHGVSVAAFPPVYLQQLIEQVREHGNPPPMRIY
CFGGDAVPQASYEQAHAYLQPQYIINGYGPTETVVTPTIWKAAPQQPCGAVYAPIGTLVG
QRSAYVMDVDLNPLPPGVAGELYLGGTGVARGYLNRPGLTAERFVADPGNPGGRLYRTGD
LVRQREDGTFDYLGRLDNQVKVRGFRIELGEIEARLADMDPVRQAAVVVRDGPSGKQLFG
YVTLAEGHAQGIAEQLRERLKQELPEYMVPAQLMVLERMPLSPNGKLDRNALPAMQALRE
HVAPRNELELAIARIWQDVLKVEQVGITDNFFELGGDSILSMQVVAKARGLKKIGFTLRL
RDLIQKSTIAELTAVAGKHSPLLSLNAPVAGQAPMFCVHAGFGTVFDYEPLARRLNGRCQ
VIGIQARQLLDGAWQEASLQSMASDYVACLREQQPHGPYRLLGWSLGGTLASLMAAVLEG
QGERVELLALLDSFVPSTQTHLQVDHWLDDLNELLQATVPSAQPVKRDVALPEGEGSARA
LITQALGNRQGATGLGVDELTQVFITARSLKRLSRELHTCQPVQVVPHSWWVAGRDDERE
ALAAQLGQALDTARLLACGHFQVPHEATLLDDVQALLEPNLTHACFIELS