Protein Info for PP_4140 in Pseudomonas putida KT2440

Annotation: lysine decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03709: OKR_DC_1_N
  • amino acids 22 to 143 (122 residues), 75.1 bits, E=7.9e-25
• PF01276: OKR_DC_1
  • amino acids 149 to 581 (433 residues), 505 bits, E=2.3e-155
• PF03711: OKR_DC_1_C
  • amino acids 607 to 736 (130 residues), 159 bits, E=1.2e-50

Best Hits

KEGG orthology group: K01582, lysine decarboxylase [EC: 4.1.1.18] (inferred from 99% identity to ppf:Pput_1725)

Predicted SEED Role

"Lysine decarboxylase, inducible (EC 4.1.1.18)" in subsystem Lysine degradation (EC 4.1.1.18)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (14/17 steps found)
• L-lysine degradation X (5/6 steps found)
• cadaverine biosynthesis (1/1 steps found)
• L-lysine degradation I (5/7 steps found)
• superpathway of polyamine biosynthesis I (5/8 steps found)
• aminopropylcadaverine biosynthesis (1/3 steps found)
• bisucaberin biosynthesis (1/5 steps found)
• desferrioxamine B biosynthesis (1/5 steps found)
• desferrioxamine E biosynthesis (1/5 steps found)
• lupanine biosynthesis (1/5 steps found)
• superpathway of L-lysine degradation (23/43 steps found)

KEGG Metabolic Maps

• Alkaloid biosynthesis II
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.18

Sequence Analysis Tools

See A0A140FWL0 at UniProt or InterPro

Protein Sequence (749 amino acids)

>PP_4140 lysine decarboxylase (Pseudomonas putida KT2440)
MYKDLKFPILIVHRAIKADSVAGERVRGIAEELRQDGFAILAAADHAEARLVAATHHGLA
CMLIAAEGAGENTHLLQNMAELIRLARLRAPNLPIFALGEQVTLENAPAEAMSELNQLRG
ILYLFEDTVPFLARQVARAAHTYLDGLLPPFFKALVQHTAQSNYSWHTPGHGGGVAYHKS
PVGQAFHQFFGENTLRSDLSVSVPELGSLLDHTGPLAEAEARAARNFGADHTFFVINGTS
TANKIVWHAMVGRDDLVLVDRNCHKSVVHAIIMTGAIPLYLCPERNELGIIGPIPLSEFS
PEAIAAKIQANPLARDRGQRIKLAVVTNSTYDGLCYHAGLIKQALGASVEVLHFDEAWFA
YAAFHDFFTGRYAMGTACAADSPLVFSTHSTHKLLAAFSQASMIHVQDGARRQLDRDRFN
EAFMMHISTSPQYSILASLDVASTMMEGPAGRSLLQEMFDEALSFRRALANLREHIAAAD
WWFSIWQPPSAEGIPRLAAQDWLLQPGAQWHGFGEVVTDYVLLDPLKVTLVMPGLSADGV
LGARGIPAAVVSKFLWERGLVVEKTGLYSFLVLFSMGITKGKWSTLLTELLEFKRHYDGN
TPLSSCLPSVGAADALRYQGMGLRDLCDQLHDCYRANATAKQLKRLFTRLPEVAVSPAQA
YDKMVRGEVEAVPIEALLGRVAAVMLVPYPPGIPLIMPGERFTEATRSILDYLAFARAFN
QGFPGFVADVHGLQHEGGRYTVDCITECA