Protein Info for PP_3588 in Pseudomonas putida KT2440

Annotation: Multidrug resistance transporter, Bcr/CflA family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 395 signal peptide" amino acids 1 to 35 (35 residues), see Phobius details transmembrane" amino acids 49 to 67 (19 residues), see Phobius details amino acids 79 to 98 (20 residues), see Phobius details amino acids 105 to 124 (20 residues), see Phobius details amino acids 136 to 158 (23 residues), see Phobius details amino acids 166 to 188 (23 residues), see Phobius details amino acids 211 to 236 (26 residues), see Phobius details amino acids 245 to 268 (24 residues), see Phobius details amino acids 280 to 298 (19 residues), see Phobius details amino acids 304 to 324 (21 residues), see Phobius details amino acids 336 to 359 (24 residues), see Phobius details amino acids 366 to 385 (20 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 15 to 378 (364 residues), 203.9 bits, see alignment E=2.7e-64 PF07690: MFS_1" amino acids 22 to 353 (332 residues), 135.6 bits, see alignment E=3.1e-43 PF00083: Sugar_tr" amino acids 45 to 190 (146 residues), 42.6 bits, see alignment E=6e-15 PF06609: TRI12" amino acids 54 to 188 (135 residues), 30.4 bits, see alignment E=2.3e-11

Best Hits

KEGG orthology group: None (inferred from 100% identity to ppu:PP_3588)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q88GX9 at UniProt or InterPro

Protein Sequence (395 amino acids)

>PP_3588 Multidrug resistance transporter, Bcr/CflA family (Pseudomonas putida KT2440)
MNRPAGSLRRHLCSTLLILLCLLGVFPLDVILPSFPALSDEFRVDTKQIAYSVSFFAVGV
AMAQIVIGPLSDGIGRKRLLLAGLSVSIVGALGCVFSTHYETFMAFRLVQALGCGSLVLG
QALVQDLYSGTQRNAMRILLTSASGLFISLSPLAGAFLQQSFGWEASFTVFVIIAAIVSL
LSCVLLHDTPASHDRAPSMSSYRVMLRDTDYLAHSMLSSLAFACHFSFIVIAPLLLMGRL
ELTAYQFSLVFIGYGLAYIVGGMAAAYLNSRVSPQTQIKAGLLLISTAGITLLMWEWVAG
LSVLGALLPMIVCTTGTTLVRPAATTQALARYPRQAGAAASLNTTLLFAGAGLTSSVVAG
LESELPAGLGVLFMVASLCGGWLLACTKDDGMQRC