Protein Info for PP_2354 in Pseudomonas putida KT2440

Annotation: Sensory box histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 795 PF00072: Response_reg" amino acids 9 to 109 (101 residues), 47.2 bits, see alignment E=7e-16 amino acids 683 to 787 (105 residues), 67.4 bits, see alignment E=3.7e-22 PF08447: PAS_3" amino acids 167 to 253 (87 residues), 34.6 bits, see alignment E=5.7e-12 amino acids 306 to 376 (71 residues), 27.4 bits, see alignment E=9.9e-10 TIGR00229: PAS domain S-box protein" amino acids 286 to 395 (110 residues), 33.5 bits, see alignment E=2e-12 PF08448: PAS_4" amino acids 289 to 393 (105 residues), 60.2 bits, see alignment E=6.4e-20 PF00512: HisKA" amino acids 428 to 493 (66 residues), 33.6 bits, see alignment E=1e-11 PF02518: HATPase_c" amino acids 537 to 656 (120 residues), 62.6 bits, see alignment E=1.4e-20

Best Hits

KEGG orthology group: None (inferred from 100% identity to ppu:PP_2354)

Predicted SEED Role

"Sensory box histidine kinase/response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q88KD6 at UniProt or InterPro

Protein Sequence (795 amino acids)

>PP_2354 Sensory box histidine kinase/response regulator (Pseudomonas putida KT2440)
MQQTPLKLLMVEDSSMDAELTLMRLERSGLHVQSQLVFDHAGVEHALRQARYDLILCDCV
LPGSSGTEVLAIAQRLAPDIPFIFLSGIYGEEHAVEMIRLGATDYVLKKNLPLLPKAVRR
ALSEVQERQRRRRAEEALADVEARARIAIDAAGMGTWDLRPQEGLLLWDDRCKTLFGVPT
STEMSLEVFYAGIYPDDLPLVREAVEHAMRPESDGHYRVEFRIAQPNGLEPRWLLSSGQS
QFVDDQCVRFSGVLQDIHAQRQATQALRQLNEMLGERVERRTRERDRAWELSQDLLAVLN
KDLTPVALNPAWEASLGFSRERLSQSSLLHLLPEHDQEQLLTELAALAHGRTSARFVGRI
LHAGGQQRWLSWVVVPEDTLLYVVARDITSEREAALSLADANARLREQINERERIEAALQ
QMQRLEAVGQLTAGVAHDFNNLLTVILTGASFLERDLAKADLDKARTRLTHIREAGERGA
KLTSQLLAFSRRQRLEPVPLNLNRTLAGLEELLRRTLGGNISVRLDLDLALWQALTDPTQ
TEMIILNLAINARDAMSDGGQLTLTTRNTLIDKRPQRPEDPDPGEYVMLSIRDTGCGMSE
EVLAKVFEPFFTTKDIGKGSGLGLAQVFGFAKQSGGGVRIDTTLGRGTEVAVYLPAVKEE
MVNEPVPAVLSQSISESGHNRTVLLVDDDHLVRDMLGDVLRQYGYQVRQAHSGEQALALL
DDDIDLLLTDFAMPEFNGAQLALAARERYPRLPVVFLTGYAELQGLELPGSLVIQKPVQA
DELARALNEMLGISG