Protein Info for PP_2080 in Pseudomonas putida KT2440

Annotation: NAD-specific glutamate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1621 PF21075: GDH_ACT1" amino acids 35 to 178 (144 residues), 162.8 bits, see alignment E=1.9e-51 PF21073: GDH_HM1" amino acids 344 to 403 (60 residues), 80.3 bits, see alignment (E = 3.1e-26) PF21076: GDH_ACT2" amino acids 407 to 496 (90 residues), 115.7 bits, see alignment 4.4e-37 PF21079: GDH_HM2" amino acids 503 to 544 (42 residues), 50.3 bits, see alignment (E = 7.7e-17) PF21077: GDH_ACT3" amino acids 551 to 630 (80 residues), 95.7 bits, see alignment 4.4e-31 PF21078: GDH_HM3" amino acids 647 to 710 (64 residues), 96.3 bits, see alignment (E = 3.7e-31) PF05088: Bac_GDH_CD" amino acids 732 to 1226 (495 residues), 898.1 bits, see alignment E=5.6e-274 PF21074: GDH_C" amino acids 1271 to 1608 (338 residues), 428.9 bits, see alignment E=6e-132

Best Hits

Swiss-Prot: 84% identical to DHE2_PSEAE: NAD-specific glutamate dehydrogenase (gdhB) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

Predicted SEED Role

"NAD-specific glutamate dehydrogenase (EC 1.4.1.2), large form" in subsystem Glutamate dehydrogenases or Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis (EC 1.4.1.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q88L55 at UniProt or InterPro

Protein Sequence (1621 amino acids)

>PP_2080 NAD-specific glutamate dehydrogenase (Pseudomonas putida KT2440)
MAFFTAASKADFQHQLQAALAQHISEQSLPQVALFAEQFFGIISLDELTQRRLSDLAGCT
LSAWRIIERFDPEYPQVRVYNPDYERNGWQSTHTVVEVLHHDLPFLVDSVRTELNRRGYS
IHTLQTTVLSVRRGAKGELLELLPKGTQGEGVRYESLMYLEIDRCANAAELTVLTREIEQ
VLAEVRVVVADFEPMKAKLREVVAQVEQTAFGPAQNEKGEVKAFLEWLLDNHFTFLGYEE
FTVKGDADGGQMVYDEQSFLGLPRRLRVGLTAEELRIEDYAVAYLNEPLLLSFAKAALPS
RVHRPAYPDYVSIRQLDADGKVIKEHRFMGLYTSSVYGESVHAIPYIRVKVAEVERRSGF
DPKAHLGKELAQVLEVLPRDDLFQTPIDELFSTVMAIVQIQERNKIRVFLRKDPYGRFCY
CLAYVPREIYSTEVRQKIQQVLMERLKASDCEFWTFFSESVLARVQLILRVDPKNRIDID
PQQLEREVIQACRSWHDDYSALVVENFGEAQGTNILADFPKGFPAGYRERFAAHSAVVDL
QHVLNLSESKPLAMSFYQPLTQVGERILHCKLYHADTPLALSDVLPILENLGLRVLGEFP
YRLRHANGREYWIHDFAFTYSEGLSLDIQQLNDTLQDAFIHIVRGDAENDAFNRLVLTAG
LPWRDVALLRAYARYLKQIRLGFDLGYIASTLNNHTDIARELTRLFKTRFYLARKLTQDD
LDDKQQRLEQAILSALDDVQVLNEDRILRRYLDLIKATLRTNFYQPDANGQNKSYFSFKF
NPKLIPELPKPVPKFEIFVYSPRVEGVHLRFGNVARGGLRWSDREEDFRTEVLGLVKAQQ
VKNSVIVPVGAKGGFLPRRLPLGGSRDEIAAEGVACYRIFISGLLDITDNLKDGGVVPPA
NVVRHDDDDPYLVVAADKGTATFSDIANGIAIDYGFWLGDAFASGGSAGYDHKKMGITAR
GAWVGVQRHFRERGINVQEDPITVIGVGDMAGDVFGNGLLMSDKLQLVAAFNHLHIFIDP
NPDPATSFAERKRLFDLPRSAWSDYDTSIMSEGGGIFPRSAKSIAISPQMKERFAIEADR
LTPTELLNALLKAPVDLLWNGGIGTYVKASTESHADVGDKANDALRVNGNELRCKVVGEG
GNLGMTQLGRVEFGLNGGATNTDFIDNAGGVDCSDHEVNIKILLNEVVQGGDMTEKQRNQ
LLGSMTDEVAGLVLGNNYKQTQALSLAARRARERIAEYKRLMADLEARGKLDRAIEFLPS
EEQLAERLAAGQGLTRAELSVLISYSKIDLKEQLLKSLVPDDDYLTRDMETAFPPSLVSK
FAEAMRRHRLKREIVSTQIANDLVNNMGITFVQRLKESTGMSPANVAGAYVIVRDIFHLP
HWFRQIEALDYQVPAEIQLTLMDELMRLGRRATRWFLRSRRNEQDAGRDTAHFGPKIAQL
GLKLDELLEGPTRERWMVRYQGFVDAGVPELLARMVAGTSHLYTLLPIIEAADVTGHEPA
QVAKAFFAVGSALDLTWYLQEISNLPVENNWQALAREAFRDDIDLQQRAITISVLQMADA
PQDMDARVALWSEQHRGMVERWRAMLDDLRNATGTDYAMYAVANRELVDLAMSGQAAVVP
S