Protein Info for PP_1806 in Pseudomonas putida KT2440

Annotation: putative arabinose 5-phosphate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 317 PF01380: SIS" amino acids 38 to 170 (133 residues), 113.2 bits, see alignment E=8.1e-37 TIGR00393: sugar isomerase, KpsF/GutQ family" amino acids 43 to 309 (267 residues), 372.5 bits, see alignment E=6.8e-116 PF00571: CBS" amino acids 199 to 253 (55 residues), 38.8 bits, see alignment E=9.9e-14 amino acids 263 to 310 (48 residues), 28.4 bits, see alignment 1.7e-10

Best Hits

Swiss-Prot: 60% identical to API_HAEIN: Probable arabinose 5-phosphate isomerase (HI_1678) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K06041, arabinose-5-phosphate isomerase [EC: 5.3.1.13] (inferred from 100% identity to ppu:PP_1806)

Predicted SEED Role

"Arabinose 5-phosphate isomerase (EC 5.3.1.13)" in subsystem KDO2-Lipid A biosynthesis (EC 5.3.1.13)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 5.3.1.13

Use Curated BLAST to search for 5.3.1.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q88LX1 at UniProt or InterPro

Protein Sequence (317 amino acids)

>PP_1806 putative arabinose 5-phosphate isomerase (Pseudomonas putida KT2440)
MKMNHLDIAKEALVAQAQAVAKLADRLDGQFQSAVDLILACEGRTVVCGMGKSGLIGKKM
VATFASTGTPSFFLHPAEAFHGDLGMLKPVDVLVLISYSGETEELIKLIPSLKSFGNKFI
AMTGSGNSTLAKHADIWLDISVDREVCPNNLAPTTSTLATMAMGDALAVALITANQFKPM
DFARYHPGGSLGRKLLTRVADVMHSPAPIVSPASSFQDCLLMMTQSRLGLAMVMDGNELV
GIVTDGDLRRALLKNNQVIHASVTEFMTLNPHTIPADCRVSVAEAYMLENKIRALAVVDD
CGAIVGVVEIFDGNPVA