Protein Info for PP_0559 in Pseudomonas putida KT2440

Annotation: acetyl-CoA carboxylase - biotin carboxyl carrier subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00531: acetyl-CoA carboxylase, biotin carboxyl carrier protein
  • amino acids 1 to 152 (152 residues), 192.8 bits, E=2.5e-61
• PF00364: Biotin_lipoyl
  • amino acids 79 to 152 (74 residues), 83.3 bits, E=8.7e-28

Best Hits

Swiss-Prot: 76% identical to BCCP_PSEAE: Biotin carboxyl carrier protein of acetyl-CoA carboxylase (accB) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K02160, acetyl-CoA carboxylase biotin carboxyl carrier protein (inferred from 99% identity to ppf:Pput_0598)

MetaCyc: 66% identical to biotin carboxyl carrier protein (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Biotin carboxyl carrier protein of acetyl-CoA carboxylase" in subsystem Fatty Acid Biosynthesis FASII

MetaCyc Pathways

• biotin-carboxyl carrier protein assembly (4/4 steps found)
• 3-hydroxypropanoate cycle (6/13 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (9/18 steps found)
• glyoxylate assimilation (5/13 steps found)
• superpathway of the 3-hydroxypropanoate cycle (6/18 steps found)

Sequence Analysis Tools

See Q88QD5 at UniProt or InterPro

Protein Sequence (153 amino acids)

>PP_0559 acetyl-CoA carboxylase - biotin carboxyl carrier subunit (Pseudomonas putida KT2440)
MDIRKVKKLIELLEESGIDELEIKEGEESVRISRHSKTPAAQQFYAPAPMAAAPAAAPVA
AAAPAAEATAAAPALKGTVVRSPMVGTFYRKPSPTSPNFAEVGQSVKKGDTLCIVEAMKM
MNHIEADIGGVIDAILVEDGQPVEFDQPLFTIV