Protein Info for PP_0043 in Pseudomonas putida KT2440

Annotation: cation efflux system protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1053 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 346 to 363 (18 residues), see Phobius details amino acids 368 to 387 (20 residues), see Phobius details amino acids 395 to 418 (24 residues), see Phobius details amino acids 452 to 471 (20 residues), see Phobius details amino acids 482 to 508 (27 residues), see Phobius details amino acids 529 to 555 (27 residues), see Phobius details amino acids 884 to 903 (20 residues), see Phobius details amino acids 910 to 929 (20 residues), see Phobius details amino acids 936 to 962 (27 residues), see Phobius details amino acids 984 to 1002 (19 residues), see Phobius details amino acids 1013 to 1036 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1048 (1048 residues), 1723.2 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1038 (1034 residues), 1142.3 bits, see alignment E=0

Best Hits

Swiss-Prot: 72% identical to CZCA_ALCSC: Cation efflux system protein CzcA (czcA) from Alcaligenes sp. (strain CT14)

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 71% identity to ajs:Ajs_1849)

MetaCyc: 100% identical to cation efflux system protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q88RT6 at UniProt or InterPro

Protein Sequence (1053 amino acids)

>PP_0043 cation efflux system protein (Pseudomonas putida KT2440)
MFERIIRFAIEQRIVVMIAVLIMAGIGIYSYQKLPIDAVPDITNVQVQINTAAPGYSPLE
TEQRITFPVETAMAGLPGLQQTRSLSRSGLSQVTVIFKDGTDIFFARQLINERLQVAKEQ
LPEGVEAVMGPVSTGLGEIFLWTVEAEDGAVKEDGTPYTPTDLRVIQDWIIKPQLRNVPG
VAEINTIGGYAKQFLVAPDPKRLATYKLTLNDLVAALESNNANVGAGYIERNGEQLLIRA
PGQVGNIEDIANIVITSVDGAPIRISSVADVSIGKELRTGAATENGREVVLGTVFMLIGE
NSRTVSQAVAAKLADINRTLPKGVVAVTVYDRTNLVEKAIATVKKNLVEGAILVIAILFL
FLGNIRAALITAMVIPLSMLFTFTGMFNNKVSANLMSLGALDFGIIVDGAVVIVENAIRR
LAHAQHKHGRMLTKTERFHEVFAAAREARRPLIFGQLIIMVVYLPIFALTGVEGKMFHPM
AFTVVMALLGAMVLSVTFVPAAIAMFVTGKVKEEEGVVMRTARLRYEPVLQWVLGHRNIA
FSAAVALVVLSGLLASRMGSEFIPSLSEGDFAMQAMRVPGTSLTQSVEMQQRLEKAVIAQ
VPEVERMFARSGTAEIASDPMPPNASDAYIMLKPQDQWPNPKKPRDELIAEVQKAAAGVP
GSNYELSQPIQLRFNELISGVRSDVAVKVFGDDMDVLNNTANKIAAALKAVPGSSEVKVE
QTSGLPVLTINIDREKAARYGLNIADVQNSIAIAVGGRQAGTLYEGDRRFDMVVRLPETV
RTDVAGMSSLLIPVPANAAQGANQIGFIPLSQVANLDLQLGPNQISRENGKRLVIVSANV
RGRDLGSFVEEATASLDKKVQIPAGYWTTWGGQFEQLQSAAKRLQIVVPVALLLVMTLLF
LMFNNLKDGMLVFTGIPFALTGGVVALWLRDIPLSISAGVGFIALSGVAVLNGLVMIAFI
RGLREEGRTLRQAVDEGALTRLRPVLMTALVASLGFIPMALATGTGAEVQRPLATVVIGG
ILSSTALTLLVLPALYHWAHRKDEDGDEAEVVS