Protein Info for OKFHMN_24145 in Escherichia coli ECRC100

Name: glpR
Annotation: transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 259 PF08279: HTH_11" amino acids 8 to 50 (43 residues), 21.4 bits, see alignment 2.8e-08 PF08220: HTH_DeoR" amino acids 8 to 60 (53 residues), 58.9 bits, see alignment E=4.9e-20 PF00455: DeoRC" amino acids 85 to 238 (154 residues), 173.6 bits, see alignment E=5e-55

Best Hits

Swiss-Prot: 33% identical to YDJF_ECOLI: Uncharacterized HTH-type transcriptional regulator YdjF (ydjF) from Escherichia coli (strain K12)

KEGG orthology group: K02436, DeoR family transcriptional regulator, galactitol utilization operon repressor (inferred from 99% identity to ecp:ECP_2128)

Predicted SEED Role

"Galactitol utilization operon repressor" in subsystem D-Tagatose and Galactitol Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (259 amino acids)

>OKFHMN_24145 transcriptional regulator (Escherichia coli ECRC100)
MTMNSFERRNKIIQLVNEQGTVLVQDLAGVFAASEATIRADLRFLEQKGVVTRFHGGAAK
IMSGNSETETQEVGFKERFQLASAPKNRIAQAAVKMIHEGMTVILDSGSTTMLIAEGLMT
AKNITVITNSLPAAFALSENKDITLVVCGGTVRHKTRSMHGSIAERSLQDINADLMFVGA
DGIDAVNGITTFNEGYSISGAMVTAANKVIAVLDSSKFNRRGFNQVLPIEKIDIIITDDA
VSDVDKLALQKTRVKLITV