Protein Info for OKFHMN_16190 in Escherichia coli ECRC100

Name: hmsP
Annotation: biofilm formation regulator HmsP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 649 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 142 to 166 (25 residues), see Phobius details PF17154: GAPES3" amino acids 23 to 142 (120 residues), 155.8 bits, see alignment E=6.9e-50 PF00990: GGDEF" amino acids 234 to 381 (148 residues), 35.7 bits, see alignment E=1.1e-12 PF00563: EAL" amino acids 402 to 635 (234 residues), 202.2 bits, see alignment E=1.2e-63

Best Hits

Swiss-Prot: 99% identical to PDEK_ECOLI: Probable cyclic di-GMP phosphodiesterase PdeK (pdeK) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to ecs:ECs4409)

MetaCyc: 99% identical to c-di-GMP phosphodiesterase PdeK (Escherichia coli K-12 substr. MG1655)
Cyclic-guanylate-specific phosphodiesterase. [EC: 3.1.4.52]

Predicted SEED Role

"Protein yhjK"

Isozymes

Compare fitness of predicted isozymes for: 3.1.4.52

Use Curated BLAST to search for 3.1.4.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (649 amino acids)

>OKFHMN_16190 biofilm formation regulator HmsP (Escherichia coli ECRC100)
MVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEAIL
ASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPANP
QPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIAREL
NAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLPNK
ALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRMIL
AQISGYDFAVIANGVHEPWHAITLGQQVLTIMSERLPIERIQLRPHCSISVAMFYGDLTA
EQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQV
EMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQER
GIMLPLSVNLSVLQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAILRP
LRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLAQS
LNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK