Protein Info for OHPLBJKB_04269 in Escherichia coli HS(pFamp)R (ATCC 700891)

Annotation: ECA polysaccharide chain length modulation protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 348 transmembrane" amino acids 31 to 50 (20 residues), see Phobius details amino acids 323 to 343 (21 residues), see Phobius details PF02706: Wzz" amino acids 15 to 87 (73 residues), 54.5 bits, see alignment E=6.3e-19

Best Hits

Swiss-Prot: 100% identical to WZZE_SHIFL: ECA polysaccharide chain length modulation protein (wzzE) from Shigella flexneri

KEGG orthology group: K05790, lipopolysaccharide biosynthesis protein WzzE (inferred from 100% identity to eco:b3785)

MetaCyc: 100% identical to enterobacterial common antigen polysaccharide co-polymerase (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"regulator of length of O-antigen component of lipopolysaccharide chains" in subsystem KDO2-Lipid A biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (348 amino acids)

>OHPLBJKB_04269 ECA polysaccharide chain length modulation protein (Escherichia coli HS(pFamp)R (ATCC 700891))
MTQPMPGKPAEDAENELDIRGLFRTLWAGKLWIIGMGLAFALIALAYTFFARQEWSSTAI
TDRPTVNMLGGYYSQQQFLRNLDVRSNMASADQPSVMDEAYKEFVMQLASWDTRREFWLQ
TDYYKQRMVGNSKADAALLDEMINNIQFIPGDFTRAVNDSVKLIAETAPDANNLLRQYVA
FASQRAASHLNDELKGAWAARTIQMKAQVKRQEEVAKAIYDRRMNSIEQALKIAEQHNIS
RSATDVPAEELPDSEMFLLGRPMLQARLENLQAVGPAFDLDYDQNRAMLNTLNVGPTLDP
RFQTYRYLRTPEEPVKRDSPRRAFLMIMWGIVGGLIGAGVALTRRCSK